Posted on 01/14/2010 6:43:52 AM PST by decimon
Experimental animal studies have shown that H. pylori shares several antigenic regions in common with acid secreting cells in gastric mucosa. Antibodies triggered by H. pylori destroy acid secreting cells due this antigenic mimicry. H. pylori infection is very common in humans, and about half of the infected patients develop atrophic changes over the years. In end stage severe atrophy, H. pylori disappears and signs of a previous infection are difficult to detect.
This research, lead by Dr. L Veijola and her colleagues in the University of Helsinki, Finland, has recently been published on January 7 , 2010 in World Journal of Gastroenterology. This study also confirmed the findings of previous studies that the serum markers of autoimmune gastritis appear with increasing frequency in patients with H. pylori infection, when the acid secreting capacity vanishes. The prevention of autoimmune atrophic gastritis, and thus pernicious anaemia, by eradicating the H. pylori would make the lifelong vitamin B12 substitution therapy unnecessary.
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Reference: Veijola LI, Oksanen AM, Sipponen PI, Rautelin HIK. Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection. World J Gastroenterol 2010; 16(1): 83-88 http://www.wjgnet.com/1007-9327/16/83.asp
Correspondence to: Lea Irene Veijola, MD, PhD, Herttoniemi Hospital, City of Helsinki, Kettutie 8, 00800 Helsinki,Finland. lea.veijola@helsinki.fi Telephone: +358-9-3105511 Fax: +358-9-19126382
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
About The WJG Press
The WJG Press mainly publishes World Journal of Gastroenterology.
Bug out ping.
Please translate into human terms what this means. Does it mean when your body no longer secrets stomach acid you slowly die by malnutrition. Caused by prolonged H. Pylori infections? What part does B12 play into treatment?
Wow, this is a major finding, then.
About 50% of the world’s population has H. Pylori. They know this causes ulcers and stomach cancer, but if half of those with the infection (which is symptomless 90% of the time as just a low-level infection) definitely get an autoimmune disorder that destroys acid-producing capacity to some extent, this is something for which people should get tested.
The stomach lining is supposed to produce “intrinsic factor,” which is required for B-12 absorption. Apparently, h. pylori in half of infected people causes the immune system to attack the stomach rather than just h. pylori. H. pylori evades the immune system in the vast majority of infections, but apparently the immune system code itself to target a small portion of the way h. pylori appears. Unfortunately, this portion also happens to be the part that looks just like key stomach cells, and the body destroys itself as it is attempting to kill h. pylori.
Translation is above my bray rate.
The B12 treatment is apparently not to treat the condition but to substitute for the B12 the H. pylori prevents you from making from, or extracting from, food.
I'm loathe to speculate further and will await some input from some medically trained folk.
Thanks for added information on B-12 absorption. Had heard of this but did not understand the linkage. I possibly still only have shallow understanding.
Thanks for additional info to clarify.
I had to look up those details myself. :-)
The prevention of autoimmune atrophic gastritis, and thus pernicious anaemia, by eradicating the H. pylori would make the lifelong vitamin B12 substitution therapy unnecessary.Thanks decimon.
thanks, bfl
Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection
The Chicoms are posting FReebies in PubMedCentral.
IMHO, this might get a real Nobel, as oppsed to the peace prize. If not a Nobel, they'll get a serious prize, JHMO.
The Chicoms are posting....
What do you mean by that neverdem?
What do you mean by that neverdem?
The URL for the World Journal of Gastroenterology is http://www.wjgnet.com/
Beijing Baishideng BioMed Scientific Co., Ltd., Room 903, Building D,Ocean International Center
No.62 Dongsihuan Zhonglu,Chaoyang District,Beijing 100025,China
Phone, fax and email info are at the bottom of the webpage.
Ping...(Thanks, neverdem!)
I was wondering the same thing.
I’m sure it’s significant but nothing I’ve ever heard of before.
OK. Picked up enough about what the implications of this are to answer my question.
Thanks for the ping!
You’re Welcome, Alamo-Girl!
Thanks for the ping.
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