Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Vitamin D Supplements Are Not Effective, And Could Be Dangerous, Studies Find
https://www.sciencealert.com/vitamin-d-tablets-may-be-worse-for-you-then-nothing-at-all
Money quote:
“While several studies in normal people failed to find any protective effects from vitamin D, others have been more worrying. One 2015 randomised study of 409 elderly people in Finland suggested that vitamin D failed to offer any benefits compared to placebo or exercise - and that fracture rates were, in fact, slightly higher.”
Vitamin D messes with melatonin too.
The influence of vitamin D supplementation on melatonin status in patients with multiple sclerosis
https://www.sciencedirect.com/science/article/abs/pii/S0889159113001785
No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data
https://pubmed.ncbi.nlm.nih.gov/34308111/
Good article for laymen. Not too many big sciency words.
Melatonin’s Importance Is So Much Bigger Than Sleep
https://www.zrtlab.com/blog/archive/melatonin-importance-is-so-much-bigger-than-sleep/
UPREGULATING IMMUNE FUNCTION AND METABOLISM WITH MELATONIN AND NIACIN [AUDIO]
https://www.drtomlive.com/podcast/upregulating-immune-function-and-metabolism-with-melatonin-and-niacin/
Thanks! I read all of these types articles. They help me decide. I don’t doubt you and what you say. It’s my nature to be cautious when it comes to what I eat or take.
Over 65 folks, morbidly obese, and otherwise sick folks need to start with:
50mg melatonin
100mg niacin
If flushing/tingly take 25mg more melatonin to alleviate flush. Add that 25mg to your next dose calculation.
If you don't flush and get groggy add another 50mg niacin and see if there is a flush. Add that 50mg increase to your next dose.
For the above scenarios you can repeat the extra dosing as needed, but make sure to keep up with the numbers for your next dose. This can help you find the sweet spot fast.
There’s also tons of info on my twitter. Run this search for just posts about or related to NIATONIN. This is an ongoing pretty much daily updated list.
https://twitter.com/search?q=%40WeThePeeple9%20niatonin&src=typed_query
We are kindred. Do you know that I make every single toiletry I use? If it goes on you, it goes in you. Think about it this way. If it goes on your skin, would you eat it?
So, I’m 66 and took 166mg of the flush Niacin and 7mg of melatonin when I tried it a few days ago. Too much Niacin and too little melatonin? That seems like a lot of melatonin. :-)
Even so, my flushing wasn’t terrible. I knew what to expect and didn’t panic. Nothing but a burning feeling in my skin all over and started really dropping off after 30 minutes. Gone in a hour. No vision or BP problems.
Those are some weird numbers. LOL. That still sounds like a pretty comprehensive flush. I'd say go to 20M/200N and see what happens. That ought to be pretty close to your sweet spot. The newest methods (especially among older folks) is if you flush add some melatonin (like 10mg) when you feel it. But remember to use that "updose" in your next calculation. For instance if you do 20M/200N and flush, then add 10M to that, next time start with 30M/200N. If that's the sweet spot, double that dose. Rinse and repeat until you get to target dose.
I was afraid of the 500mg of flush Niacin so I divided the powder into three even sections and put each section in a #2 capsule. That divided the 500mg into doses of 166.7mg each. Now, it’s not perfect I’m sure but that’s how it worked out. The only Melatonin I had on hand was the bottle of 5mg I take nightly. I halved another one to make it 7mg. They are not sublingual but are fast dissolving and break easily. I usually chew them up. :-)
I should receive the bag of Melatonin powder I ordered soon. I also ordered the little teeny measuring spoons that were advertised with the Melatonin. The 1/64 spoon measures 45mg of Melatonin. Once I get everything together I’ll give it another go.
bkmk
You can make tiny spoons out of straws and I suggest you wait for the powder. Volume measurement is a recipe for disaster (says the baker in me). And scales, you need scales.
Off to get a scale. Even if I don't continue with the Niatonin I can use it to measure my powdered C.
.001 - mg scale.
Are you making liposomal C?
Over in the Quilting Bee you were talking about Zinc and Quercetin. You’ll need to drop those once you get into the NIATONIN protocol. Zinc supplementation will screw up your copper balance and quercetin interferes with niacin. Any others need to be 3 hrs removed from NIATONIN dosing.
I have no idea. It’s powdered C. I originally bought it to put in the serum. I realized then that it could be taken internally. The C that I was taking had too much other junk in it and upset my stomach. This doesn’t and it doesn’t upset my stomach. I take this one time a day.
This:
https://www.amazon.com/gp/product/B07663PMR4/ref=ppx_yo_dt_b_asin_title_o06_s00?ie=UTF8&psc=1
Got it!
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