Free Republic

AP BUSINESS WRITER TRENTON, N.J. -- The maker of Zoloft is being sued in an unusual case alleging the popular antidepressant has no more benefit than a dummy pill and that patients who took it should be reimbursed for their costs. --snip-- He said Pfizer produced two studies showing Zoloft worked better than placebo - the FDA's requirement for approval - but most Zoloft studies showed its effect was the same as a placebo. Dr. Michael Thase, who heads the mood and anxiety disorders program at the University of Pennsylvania's medical school, said research by others using the same unpublished...

The report [51] provided a clinical window into the development of obsessive violence and a school shooter mentality. A twelve-year-old boy on fluoxetine developed nightmares about becoming a school shooter and then began to lose track of reality concerning these events. This case occurred in a controlled clinical trial and the investigators did not know that the child was getting fluoxetine until they broke the double-blind code. The child’s reaction occurred long before any of the well-known school shootings had taken place. Therefore, his reaction was not inspired by the school shootings; it was not a “copycat”: [51] R. King,...

Exclusive: Barbara Simpson questions role of prescription meds in shootings The countdown had begun. Christmas Eve was just 10 days away. For the children, excitement was building, as it should. Then, in a burst of what can only be described as naked evil, it was over. What had begun as a normal school day took a turn no one could have anticipated or even imagined. Sandy Hook Elementary School, grades K through 4, in the quiet village of Newtown, Conn., became the target of a plot that was carried out with diabolical accuracy that turned classrooms into a charnel house....

Some widely prescribed drugs for depression provide relief in extreme cases but are no more effective than placebo pills for most patients, according to a new analysis released Tuesday. The latest study may settle a debate about drugs like Prozac. The findings could help settle a longstanding debate about antidepressants. While the study does not imply that the drugs are worthless for anyone with moderate to serious depression — many such people do seem to benefit — it does provide one likely explanation for the sharp disagreement among experts about the drugs’ overall effectiveness.

Against Depression, a Sugar Pill Is Hard to Beat Placebos Improve Mood, Change Brain Chemistry in Majority of Trials of Antidepressants By Shankar Vedantam Washington Post Staff Writer Tuesday, May 7, 2002; Page A01 A new analysis has found that in the majority of trials conducted by drug companies in recent decades, sugar pills have done as well as -- or better than -- antidepressants.Companies have had to conduct numerous trials to get two that show a positive result, which is the Food and Drug Administration's minimum for approval. What's more, the sugar pills, or placebos, cause profound changes in...

Systematic Consumer Fraud by GSK (GlaxoSmithKline)in conspiracy with researchers who were bribed to suppress or obscure suicide risk data during clinical trials of one of the highest selling medicines-Paroxetine.

Such sexual symptoms have long been known side effects of the popular Prozac class of antidepressants, but a growing body of research suggests that they are far more common than previously thought, perhaps affecting half or more of patients. And a handful of recent medical and psychological journal articles document a small number of cases in which sexual problems remain even after a patient goes off the drugs. "This is such an upsetting issue," said Aline Zoldbrod, a Lexington psychologist and sex therapist. "There are people for whom SSRIs are really life-saving, I think, but the idea that someone would...

Is TV stock picker Jim Cramer, a longtime Democratic donor, doing his best to spread hysteria in the stock market? Today before the market opened Cramer sounded almost apocalyptic, and before the trading day was over, the Dow Jones Industrial Average was below 10,000 for the first time since 2004. According to MSNBC.com: Bullish investors should turn into shrinking violets as the stock market continues its shocking downward spiral, CNBC’s “Mad Money” host Jim Cramer told Ann Curry on TODAY Monday. In what Curry called a “dramatic statement,” Cramer emphatically urged any investor who has money they may need in...

Coroner officials released an autopsy report Friday suggesting that a slain Roosevelt High School sophomore who attacked a campus police officer was not taking proper dosages of drugs prescribed to control his mental illness. Dr. David Hadden, Fresno County coroner, said it's clear that Jesus "Jesse" Carrizales, 17, had a high dose of the antidepressant Lexapro in his blood that could have caused him to be paranoid. But the teen's blood also revealed he was not taking antipsychotic drugs. Carrizales' family has said he was taking Lexapro and Geodon, an antipsychotic medication, for depression. Hadden said it's far too early...

Gunman's Contradictions Confound Police By ASHLEY M. HEHER and CARYN ROUSSEAU – DEKALB, Ill. (AP) — Steven Kazmierczak had the look of a boyish graduate student — except for the disturbing tattoos that covered his arms. Professors and students knew him as a bright, helpful scholar, but his past included a stint in a mental health center. Many saw him as happy and stable, but he had developed a recent interest in guns and was involved in a troubled — possibly abusive — on-again, off-again relationship. What people initially told police about the Northern Illinois University shooter didn't add up,...

Steven Kazmierczak had been taking three drugs prescribed for him by his psychiatrist, the Northern Illinois University gunman's girlfriend told CNN. Jessica Baty said Steven Kazmierczak was irritable but not erratic before his shooting rampage. Jessica Baty said Tuesday that her boyfriend of two years had been taking Xanax, used to treat anxiety, and Ambien, a sleep agent, as well as the antidepressant Prozac. Baty said the psychiatrist prescribed the medications, a fact that made her so "nervous" that she tried to persuade Kazmierczak to stop taking one of the drugs.

Steven P. Kazmierczak stopped taking Prozac before he shot to death five Northern Illinois University students and himself, his girlfriend said Sunday in a remark likely to fuel the debate over the risks and benefits of drug treatment for emotional problems. A funeral on Monday in Cicero, Ill., for Catalina Garcia, 20, who was one of five students killed in a shooting Thursday in a lecture hall at Northern Illinois University. Over the years, the antidepressant Prozac and its cousins, including Paxil and Zoloft, have been linked to suicide and violence in hundreds of patients. Tens of millions of people...

Despite recent bad publicity over withheld studies showing marginal results, the resume of America's arsenal of antidepressants is enviable: consort to celebrities, subject of best-selling books and tabloid headlines. They may be the most celebrated pills since Valium. Prozac, Zoloft, Paxil, Celexa and Lexapro, among others, have become both household words and medicine-cabinet staples. Known collectively as selective serotonin reuptake inhibitors, or SSRIs, these antidepressants are prescribed for anxiety, social phobia, obsessive-compulsive disorder and numerous conditions besides depression. SSRIs are now the most commonly prescribed of all medications in this country. The rate at which physicians prescribed SSRIs more than...

The quandary: Preventing deadly campus shootings while respecting rights A week ago, Steven Kazmierczak walked into Tony's Guns & Ammo, a yellow shop in a back yard near the University of Illinois, and bought a Remington shotgun and a 9 mm Glock pistol. Around the same time, family members noticed that Kazmierczak was acting "erratically," after he had stopped taking prescription medicines for anxiety. Kazmierczak used his two new guns, and two more he had also purchased legally, to kill five students and himself Thursday in a shooting rampage at Northern Illinois University that leaves policymakers again scrambling to figure...

"When I was lying in my bed that night, I couldn’t sleep because my voice in my head kept echoing through my mind telling me to kill them." You're reading the words of 12-year-old Christopher Pittman, struggling to explain why he murdered his grandparents, who had provided the only love and stability in his turbulent life. He was angry with his grandfather, who had disciplined him earlier that day for hurting another student during a fight on the school bus. So later that night, he shot both of his grandparents in the head with a .410 shotgun as they...

AN expression of true love or raw hatred, of purest faith or mortal sin, of courageous loyalty or selfish cowardice: The act of suicide has meant many things to many people through history, from the fifth-century Christian martyrs to the Samurais’ hara-kiri to more recent literary divas, Hemingway, Plath, Sexton. But now the shadow of suicide has slipped into the corridors of modern medicine as a potential drug side effect, where it is creating a scientific debate as divisive and confounding as any religious clash. And the shadow is likely to deepen. After a years-long debate about whether antidepressant drugs...

Associated Press Attorneys have asked the U.S. Supreme Court to hear the case of a teen sentenced to 30 years in prison for killing his grandparents when he was 12, arguing that the sentence is cruel. Christopher Pittman shoot his grandparents Joe and Joy Pittman with a shotgun in 2001, then set fire to their home. During his trial four years later, Pittman's attorneys unsuccessfully argued the slayings were influenced by the antidepressant Zoloft - a charge the maker of the drug vigorously denied. In the brief submitted to the high court late Monday, attorneys from the University of Texas...

The Loss of Sadness: How Psychiatry Transformed Normal Sorrow into Depressive Disorder by Allan V. Horwitz and Jerome C. Wakefield Oxford University Press, 287 pp., $29.95 Shyness: How Normal Behavior Became a Sickness by Christopher Lane Yale University Press, 263 pp., $27.50 Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry and Depression by David Healy New York University Press, 351 pp., $18.95 (paper) 1. During the summer of 2002, The Oprah Winfrey Show was graced by a visit from Ricky Williams, the Heisman Trophy holder and running back extraordinaire of the Miami Dolphins. Williams was there to...

Parents do a lot of guessing on what could be troubling a fussy baby.  If he's crying, he may be hungry or tired. But could he be depressed?  Any parent knows that young children have to be protected from a mind-boggling number of risks, but many will be surprised to learn that infant depression could be one of them.  "Babies can be depressed," said Dr. Jess Shatkin, director of education and training at New York University's Child Study Center. "It's not a terribly common phenomenon. We think maybe one in 40 or so — but it can certainly happen."Although it's...

The results of two new studies may signal a substantial shift in the way psychiatrists and researchers think about treatment for severely depressed patients. --snip-- In the other, psychiatrists in New York found evidence that antidepressant drugs significantly increased the risk that some children and adolescents would attempt or commit suicide. Doctors have debated this risk for years, but the authors of the study were skeptical of it, and their report may sway others. --snip-- The study of suicide risk, led by Dr. Mark Olfson of Columbia University and the New York State Psychiatric Institute, was based on an analysis...