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Healthy people taking vitamin D supplements are unlikely to see any significant impact when it comes to preventing broken bones or cardiovascular conditions, claims new research appearing in the latest edition of The Lancet Diabetes & Endocrinology. According to the AFP news agency, the study authors reviewed more than 40 previous trials in order to determine whether or not use of these vitamin supplements achieved a benchmark of reducing the risk of heart attacks, strokes, cancer or bone fractures by at least 15 percent. “Previous research had seen a strong link between vitamin D deficiency and poor health in these...

Chester, NJ—A recent clinical trial published in Phytotherapy Research indicated that a high-absorption curcumin (BCM-95 from Dolcas Biotech, based here) had similar effects as a generic form of Prozac (fluoxetine) on depression, sans the adverse effects. “It is a novel and surprising application for this natural medicine,” said Ajay Goel, Ph.D., Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center and study co-author. “People with depression have higher levels of inflammation in the brain. Also, people with depression have lower levels of neurogenesis in the brain, meaning they make fewer new brain cells than people with no...

One of the curcumin–thalidomide hybridsCancer researchers in the US and China have combined the turmeric spice pigment curcumin and the drug thalidomide to create hybrid compounds that can kill multiple myeloma cells.Multiple myeloma is the second most common type of blood cancer, killing 20% of affected patients each year. The drug thalidomide, banned after causing birth defects when given during pregnancy in the 1950s, was recently rediscovered and approved for the treatment of multiple myeloma. Thalidomide works by disturbing the microenvironment of tumour cells in bone marrow. However, it disintegrates in the body. Curcumin, a yellow pigment from the common...

NEW YORK — Pfizer Inc. and Johnson & Johnson said Monday they are ending development of an intravenous formulation of a drug to treat Alzheimer’s disease after the treatment failed in two late-stage clinical trials. The companies said bapineuzumab intravenous did not work better than placebo in two late-stage trials in patients who had mild to moderate Alzheimer’s disease. The drug is designed to prevent the buildup of plaque in the brain. J&J said it is not discontinuing development of the compound and noted it has ongoing studies including a mid-stage neuroimaging study with bapineuzumab delivered subcutaneously...

Curcumin shows promise in fighting devastating viruses. It stopped the potentially deadly Rift Valley Fever virus from multiplying in infected cells, says Aarthi Narayanan, lead investigator on the new study and a research assistant professor with Mason's National Center for Biodefense and Infectious Diseases. "Curcumin is, by its very nature, broad spectrum," Narayanan says. "However, in the published article, we provide evidence that curcumin may interfere with how the virus manipulates the human cell to stop the cell from responding to the infection." Ultimately, curcumin could be part of drug therapies that help defeat these [deadly] viruses, Narayanan says. "I...

Study could have an impact in fighting head and neck cancersCurcumin, the main component in the spice turmeric, suppresses a cell signaling pathway that drives the growth of head and neck cancer, according to a pilot study using human saliva by researchers at UCLA's Jonsson Comprehensive Cancer Center. The inhibition of the cell signaling pathway also correlated with reduced expression of a number of pro-inflammatory cytokines, or signaling molecules, in the saliva that promote cancer growth, said Dr. Marilene Wang, a professor of head and neck surgery, senior author of the study and a Jonsson Cancer Center researcher. "This study...

A drug derived from the curry spice turmeric may be able to help the body repair some of the damage caused in the immediate aftermath of a stroke. Researchers at Cedars-Sinai Medical Center in Los Angeles are preparing to embark on human trials after promising results in rabbits. Their drug reached brain cells and reduced muscle and movement problems. The Stroke Association said it was the "first significant research" suggesting that the compound could aid stroke patients. "This is the first significant research to show that turmeric could be beneficial to stroke patients by encouraging new cells to grow and...

Early research findings may lead to new treatments for the diseaseUCLA scientists and colleagues from UC Riverside and the Human BioMolecular Research Institute have found that a form of vitamin D, together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, which forms the plaques considered the hallmark of Alzheimer's disease. The early research findings, which appear in the July issue of the Journal of Alzheimer's Disease, may lead to new approaches in preventing and treating Alzheimer's by utilizing the property of vitamin D3 — a form...

Curcumin, an ingredient in the curry spice turmeric, may help prevent heart failure. That's according to two new studies done on rats, not people. In both studies, researchers gave curcumin to rats. The rats then got surgery or drugs designed to put them at risk of heart failure. The rats that got curcumin showed more resistance to heart failure and inflammation than comparison groups of rats that didn't get curcumin. Also, in one of the studies, the researchers saw signs that curcumin treatment reversed heart enlargement. The other study didn't include that experiment. Together, the studies suggest that curcumin short-circuited...

Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent Heart FailureTurmeric. Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure. (Credit: iStockphoto/Nilesh Bhange) ScienceDaily (Feb. 22, 2008) — Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure, researchers at the Peter Munk Cardiac Centre of the Toronto General Hospital have discovered. In a study entitled, “Curcumin prevents and reverses murine cardiac hypertrophy,” published in the February edition of the Journal of Clinical Investigation, researchers found when the herb is given...

Source: University of California - Los Angeles Date: July 17, 2007 Scientists Isolate Chemical In Curry That May Help Immune System Clear Plaques Found In Alzheimer's Science Daily — Researchers have isolated bisdemethoxycurcumin, the active ingredient of curcuminoids -- a natural substance found in turmeric root -- that may help boost the immune system in clearing amyloid beta, a peptide that forms the plaques found in Alzheimer's disease. Using blood samples from Alzheimer's disease patients, researchers found that bisdemethoxycurcumin boosted immune cells called macrophages to clear amyloid beta. Ground turmeric in small bowl. (Credit: iStockphoto/Jenny Horne)In addition, researchers identified the...

UCLA/VA Study Finds Chemical Found in Curry May Help Immune System Clear Amyloid Plaques Found in Alzheimer’s Disease UCLA/VA researchers found that curcumin — a chemical found in curry and turmeric — may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease. Published in the Oct. 9 issue of the Journal of Alzheimer's Disease, the early laboratory findings may lead to a new approach in treating Alzheimer's disease by enhancing the natural function of the immune system using curcumin, known for its anti-inflammatory and anti-oxidant properties. Using blood samples from six...

Hopkins study shows combination of curcumin and quercetin greatly reduces size and number of colorectal polyps A small but informative clinical trial by Johns Hopkins investigators shows that a pill combining chemicals found in turmeric, a spice used in curries, and onions reduces both the size and number of precancerous lesions in the human intestinal tract. In the study, published in the August issue of Clinical Gastroenterology and Hepatology, five patients with an inherited form of precancerous polyps in the lower bowel known as familial adenomatous polyposis (FAP) were treated with regular doses of curcumin (the chemical found in turmeric)...

Ladies, if you love your man, give him cauliflower curry with a side of kale for dinner. It may stave off prostate cancer, according to research released yesterday by Rutgers University. Though they don't often make the favorite menus of most men, cauliflower and kale -- along with cabbage, broccoli, brussels sprouts, kohlrabi, watercress and turnips -- contain a chemical that is a significant cancer-preventive.

The University of Texas M.D. Anderson Cancer Center, the epitome of the conventional cancer establishment, is reporting promising test results on an unconventional weapon: a common spice used in Indian cooking. In a host of studies, M.D. Anderson researchers are showing that curcumin, the pungent yellow spice in both turmeric and curry powders, has potent anti-cancer properties. They say it may prove effective for both prevention and treatment. "Curcumin's promise is enormous," said Bharat B. Aggarwal, a professor of cancer medicine in M.D. Anderson's department of experimental therapeutics. "It appears to inhibit multiple pathways by which cancer grows, and we...

FRIDAY, June 10 (HealthDay News) -- Cancer researchers have been given a million-dollar grant to investigate the therapeutic value of the folk medicine propolis and the food spice turmeric. The U.S. National Cancer Institute grant is earmarked for the study of the two alternative remedies, each of which has shown promise in reducing risks for breast, prostate and colorectal malignancies, and in enhancing cancer treatment. Propolis and turmeric are rich in plant polyphenolic compounds that exhibit potent antitumor activities, the researchers said. "A very interesting property of these compounds is that they have been shown to cause cell death in...

Curry Ingredient, curcumin, may help  Treat Alzheimer's   Alzheimer's disease is an irreversible, progressive brain disorder that occurs gradually over time and results in memory loss, unusual behavior, personality changes and a decline in thinking abilities. It affects more than 4 million Americans and many millions across the globe. However, the prevalence of Alzheimer's disease among adults ages 70 to 79 in India is more than four times less than the rate in the United States. Why such a significant difference? Some researchers believe the answer for this drastic disparity in Alzheimer's patients found in India is a direct...

UCLA-VA study names India dietary staple as potential Alzheimer's weapon Yellow pigment in curry spice blocks, breaks up brain plaques in mice A dietary staple of India, where Alzheimer's disease rates are reportedly among the world's lowest, holds potential as a weapon in the fight against the disease. The new UCLA-Veterans Affairs study involving genetically altered mice suggests that curcumin, the yellow pigment in curry spice, inhibits the accumulation of destructive beta amyloids in the brains of Alzheimer's patients and also breaks up existing plaques. Reporting in the Dec. 7, 2004, online edition of the Journal of Biological Chemistry, the...