Posted on 10/07/2006 10:24:44 AM PDT by FairOpinion
UCLA/VA Study Finds Chemical Found in Curry May Help Immune System Clear Amyloid Plaques Found in Alzheimer’s Disease
UCLA/VA researchers found that curcumin — a chemical found in curry and turmeric — may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease.
Published in the Oct. 9 issue of the Journal of Alzheimer's Disease, the early laboratory findings may lead to a new approach in treating Alzheimer's disease by enhancing the natural function of the immune system using curcumin, known for its anti-inflammatory and anti-oxidant properties.
Using blood samples from six Alzheimer's disease patients and three healthy control patients, the researchers isolated cells called macrophages, which are the immune system's PacMen that travel through the brain and body, gobbling up waste products, including amyloid beta.
The team treated the macrophages with a drug derived from curcumin for 24 hours in a cell culture and then introduced amyloid beta. Treated macrophages from three out of six Alzheimer's disease patients showed improved uptake or ingestion of the waste product compared to the patients' macrophages not treated with curcumin. Macrophages from the healthy controls, which were already effectively clearing amyloid beta, showed no change when curcumin was added.
"Curcumin improved ingestion of amyloid beta by immune cells in 50 percent of patients with Alzheimer's disease. These initial findings demonstrate that curcumin may help boost the immune system of specific Alzheimer's disease patients," said Dr. Milan Fiala, study author and a researcher with the David Geffen School of Medicine at UCLA and the VA Greater Los Angeles Health Care System. "We are hopeful that these positive results in a test tube may translate to clinical use, but more studies need to be done before curcumin can be recommended."
The patients ranged in age from 65 to 84. Fiala noted that the patients whose immune cells responded were younger and had higher scores on a Mini-Mental State Examination suggesting that curcumin may help those with less advanced dementia. Some of the patients may have already had additional curcumin in their systems due to participation in another UCLA study, which may have impacted findings.
"Our next step will be to identify the factors that helped these immune cells respond," said Laura Zhang, a study author and a UCLA/VA research assistant in Fiala's lab.
Fiala noted that the method researchers used to test the immune cell response of macrophages may provide a novel way of evaluating the effectiveness of drugs in clearing amyloid beta from the brain and may help to individualize Alzheimer's disease treatment.
According to Fiala, macrophages are the soldiers of the innate immune system — the part of the immune system which is present at birth. Curcumin may support the body's natural immune fighting function in directly helping macrophages clean away amyloid-beta. The treatment of macrophages with curcumin is radically different from some of the vaccine approaches currently being studied.
The study was funded by the Alzheimer's Disease Association and private donors. The curcumin derived drug was provided by the Sabinsa Corporation, a company that manufacturers phytonutrients and specialty chemicals for nutritional, pharmaceutical and food industries. Fiala participated in a speaking engagement for Sabinsa.
Other study authors include: Michelle Mahanian, Justin Zaghi and Mark Rosenthal from the Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA; John Cashman of the Human BioMolecular Research Institute, San Diego; James Sayre of the Department of Biostatistics, UCLA School of Public Health; Araceli Espinosa of the UCLA Department of Neurobiology; Vladimir Badmaev, Applied Pharmacology, Sabinsa Corporation, New Jersey; Michael C. Graves, UCLA Department of Neurology; and George Bernard, UCLA Department of Neurology and Division of Oral Biology and Medicine, UCLA School of Dentistry.
The research is important, because it sounds like curcumin could not only prevent, but reverse early Alzeimers by helping the immune system to actually clear the amyloid plaques in the brain, which are believed to be what causes mental deterioration in Alzheimer's.
PING
ping.
Wonder what the stats. are for Alzheimer's in countries like India, Pakistan, China?
So the solution is obvious. Get stoned, get the munchies, and then go pig out at the nearest all-you-can-eat Indian buffet. You'll never get Alzheimers.
Well, the pot article was a satire from Scrappleface. Funny, but not medically recommended.
The VA is America's first and only true "universal healthcare system." While it is unbelievably expensive and has many, many problems, it does provide a excellent, broadbased platform for research and training. I hope they keep up this work on this scurge of a disease.
Wow man
Cool graphics dude
Curried Hash
* 1 part curry
* 3 to 4 parts powdered hashish
Half fill a jar with the ingredients and shake vigorously to blend them homogeneously.
A teaspoon of the mixture may be sprinkled upon any suitable small dish. Hot buttered rice and vegetables are ideal because of the fat content. Do not use with heavy meals as this will produce a very poor effect.
http://users.lycaeum.org/~sky/data/cooking.html
Sounds easy and (if you grow your own) cheap
It was actually from CBS, detailing research from Scripps Research Institute that was published recently.
Two different articles, then.
Outstanding post!
I use curcumin (comes in capsules, cheap) for RA and it really helps with that, too.
It's good to know it may help my poor old brain, as well. ;-D
“The dope smoking Alzheimer’s patient still suffers from memory loss, impaired decision-making, and diminished language and movement skills,” according to one unnamed scientist, “but it’s no longer a terrible disease that’s causing the symptoms, so you don’t have that stigma of being a victim.”
I'm inclined to think Scrappleface has it right. You can be out of it with Alzheimers or out of it with pot, but either way you're still out of it. I'm going to investigate the curry angle.
bttt
I wonder how much curcumin a person would have to take in order to soak their white blood cells in it.
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