If DNA and RNA are the “message” transmitted by radio wave, the “message” only conveys “information” if it results in an active functional protein.
Proteins are also able to convey “messages” as in the example of Signal Transduction.
Your writing about Prion is an absolute embarrassment, and it was the very first thing I read.
If you are actually interested in conveying a “message” to those able to understand it, it would behoove you to become more knowledgeable about the subject and clean up your language as the things you say make no sense to someone who understands the subject.
Or to sum it up:
Information is the reduction of uncertainty (Shannon entropy) in the receiver (or molecular machine) as it goes from a before state to an after state.
It is the action of successful communication not any particular element of it.
For instance, it is not the message. It doesn't matter whether the message is DNA, RNA, Hamlet, this reply, etc.
Nor is it the language, though the sender (encoding) and receiver (decoding) should speak the same language (semiosis) for the communication to be successful. It does no good to send a letter in Spanish to someone who only understands Greek. In our little sidebar, I am speaking in one language and you are speaking in another. But I'd wager the Lurkers on the Religion Forum are more apt to successfully receive what I have been broadcasting.
"Broadcast" brings up another element of Shannon's model that the Religion Forum Lurkers would find interesting. A successful communication is autonomous between sender and receiver. "Noise" in the model can also be a broadcast message from an external sender, e.g. God speaking creatures into being.
Personally, I see the unreasonable effectiveness of math as God's copyright notice on the cosmos.