Pressure can be applied. See recent example of Raiders coach forced to resign for leaked emails.
Thing is, while her incompetence is astounding, she is probably the least corrupt person in the Biden admin. So probably not much to leverage for pressure to resign.
IMO.. Biden and Harris will be removed by an UNEXPECTED EVENT.
Whether it's done simultaneously or individually I think the "string pullers" feel BOTH Biden and Harris have served their purpose and it's time for BOTH to be REMOVED.