Likely. If you’re not squeamish about hunting videos, here’s one of a near miss on a deer with a .50 BMG. It attests to the energy carried by a bullet, and the energy of a shock wave.
https://m.youtube.com/watch?v=6P3uwl5HzzQ&t=18s
I’ve seen non-vital organ .243 shots drop them in their tracks (my kids were shooting).