BREAKING: Tolicizumab (Actemra) shown to be more effective than hydroxychloroquine in treating coronavirus patients, Italian doctors say

Tech Startup ^ | March 27, 2020

[aquila48]

For the past two weeks now, we’ve been talking about hydroxychloroquine as the wonder drug in the fight against the deadly coronavirus. Two anti-malaria drugs hydroxychloroquine and chloroquine are shown to be effective in treating COVID-19 patients after controlled clinical study conducted by doctors ​in France shows that a combo of Hydroxychloroquine and Azithromycin (Z-Pak) cures 100% of coronavirus patients within 6 days of treatment.

However, according to doctors treating coronovirus patients in Italy, Tolicizumab, a drug used to treat moderate to severe rheumatoid arthritis, has been shown to be more effective than hydroxychloroquine. Tolicizumab is so effective that the FDA gives green lights to Phase III Tocilizumab Trial for COVID-19 pneumonia. In a related report, Italian doctors said that a 101-year-old Italian man who survived the 1918 Spanish flu pandemic and World War II, recovered from COVID-19.

In another report, scientists claim Tocilizumab has been shown to help cure 95 percent of critically ill coronavirus patients in China. Tocilizumab, which is marketed as Actemra, is taken by patients with rheumatoid arthritis to reduce inflammation. Chinese doctors gave it to 20 patients during the peak of of coronavirus epidemic. Nineteen of the patients were discharged within 14 days despite being critically ill. Actemra has now been approved for use in China and for trials in the US

In response to a question from another doctor on hydroxychloroquine, Dr. Giusppe Galati, an Italian doctor, said in a tweet: “Dear @DrLuizSilva1 despite the large noise on social media. Here in Flag of Italy they are trying several combinations of antiviral included the combination HCQ + azithro. Infectivologist refer little benefit. The unique drug which is causing impressive improvement is #Tolicizumab.”

Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R).

[deweyfrank]

Well, I’m not a doctor, but I was referring to the video between Dr. Zelenko and Rudy. In it, Dr. Zelenko stated that he has been using the HCQ, Z-Pac, and Zinc combo. That he used it on close to 500 patients with 100% success rate. He stated that the HCQ acted as a conduit for the Zinc to penetrate and actually kill the virus. The zinc was the key he said. I would just like to see some others try it and see if it works. Sounded believable to me, but what do I know. And I haven’t heard anything from Rudy yet, so I’m becoming skeptical too.

[BDParrish]

Good comment Dewey!
I do believe the effect and I saw the data that the RdRP’s were repressed by the zinc once inside the cells. They were playing with many metal ionophores and were looking for a way to kill the cancer cells. Along the way in cancer research there are lots of disappointments but there are useful discoveries too which I hope this to be. Why does the HCQ open only the infected cells? Why not all cells? What is the mechanism by which zinc interferes with the RdRPs?

You saw Dr Zev saying to use it early and even as a prophylaxis. Once the patient is crashing it is too late. Hopeful news about biologics showing promise in those cases.

Prayers up!

[Vermont Lt]

The Spanish flu was around for three years.

[deweyfrank]

Thank you, and God Bless. Stay safe.

[TigersEye]

According to this Doctor, it’s the zink that does the killing of the virus. HCQ is just a conduit.

Yes, that is what I have understood from the start.

[TigersEye]

and doesn’t know how many people he haS treated even have covid. He is treating everyone with the sniffles

Both of those statements are apparently false. First, he says all had Covid-19. Secondly, he stated in the video that patients who call him on the phone get the response "if you can call me you don't need treatment" so he is definitely NOT treating "everyone with the sniffles."

Dr. Vladimir Zelenko has now treated 699 coronavirus patients with 100% success using Hydroxychloroquine Sulfate, Zinc and Z-Pak

[Bob434]

thanks, i was gonna reply to her comment- but you saved me from doing so-

[Bob434]

[[You saw Dr Zev saying to use it early and even as a prophylaxis.]]

A lot of doctors and apparently nurses and i would imagine health care workers too are using it that way- for a drug that ‘hasn’t been clinical trialed yet, and therefore4 not available to patients in sum states, i find it odd that medical personnel are using it themselves-

[Bob434]

Thanks, i had sped read that article before- it does look though that 65% infact did have covid- and none of them died- which means 434 had the virus, and all survived- He didn’t treat the young people with no breathign issues

3. Young, healthy and low risk patients even with symptoms are not treated

just those with issues breathing given the seriousness of the virus- whether they actually had covid or not- turns out 65% did- and out of that 434 people, he had a 100% success rate- apparently0-

[Bob434]

I guess the point is now- while his findings weren’t an official clinical trial, it was anecdotal evidence, and during pandemics, anecdotal evidences can mean the difference between life and death- and it seems there is growing evidence that the Hydroxy dug is saving lives- lots of lives % wise

But we’ll have to wait for NY results, and the new Washington results too- BUT- people should be given the choice to get these drugs if they choose, while they are waiting- as there is ample evidence the drug is safe, used for a long time without serious concerns- and because there is now growing evidence it’s working- We are now practically, if not actually, at a point where withholding it is immoral-

[BDParrish]

Hey Bob, Brian here.

Long ago there was a lab test where some Chloroquine was put in with some SARS-Cov and a definite effect was observed and documented. There was no Zpac and no zinc. But the virus was inhibited compared to a control. Then the pandemic was over and that work was left with a sigh of relief. It was a big scare ya know?

When the Chines doctors right after Christmas looked at this new virus, at first they thought it WAS SARS again. The ran the Sanger Sequencing, and put it through an Homology Modeler available to everyone online. It was different enough to declare it a novel coronavirus, but it was so close, so we got the name SARS-Cov-2.

Chloroquine is still available in Africa but not in China. They had Hydroxyl-Chloroquine the safer version and decided to try it and it showed the same effect. In hospital though they reported disappointing results. The South Koreans used the Zpac with it and perhaps the zinc too getting better results.

I cannot verify that it is actually unavailable anywhere. What I am seeing is that some doctors just don’t believe in it. They want to see a dramatic effect in the ICU and that is not happening.

If we follow Zelensky and give HCQ early,
and if the biologic does what we think it will do in the ICU,
and if more convalescent plasma is identified and administered,
and if remdesivir can get approved,
and if the vaccine plays out like we hope...

[Bob434]

[[What I am seeing is that some doctors just don’t believe in it. They want to see a dramatic effect in the ICU and that is not happening]]

While ignoring the dramatic effect of people dying by the 1000’s

nearly 4000 are dead now in the US and there was no need for it- most could have been saved-

Where have you seen that there isn’t a dramatic effect i n the ICU? Everything I’ve read is that it is working for all cases- mild and severe- several folks have said they went ot sleep not expecting to wake up they were so close to death, and they recovered fully

[[I cannot verify that it is actually unavailable anywhere.]]

In some states you must be a part of the trials, a couple of states have declared doctors can not prescribe it- Small towns simply will not have the drug- even though we now have tens of millions of doses-

Doctors are taking it themselves as a preventative— and aren’t getting the virus- so for those docs that don’t believe in it, I’m guessing they are taking it themselves-

Time is of the essence- there’s no time to waste- use the drug- it’s proven safe- and use it while we wait for other drugs to come online- it’s people’s best chance at survival right now- nearly 1000 people died today in US- there’s no need for it-

[BTerclinger]

WOW!

[UCANSEE2]

Lots of very good information on that question contained down thread.

Saw those posts. Read them. Thanks.

[UCANSEE2]

Several countries have donate millions upon millions of doses to the USD- why isn’t it widely available? We have way mroe than enough- way more-

Maybe it's because we're a nation that can't ensure everyone only gets ONE VOTE, little lone ensuring they get the proper amount of medication and don't hoard it.

[UCANSEE2]

Like you, I now understand more about how the name of a medicine in conjured up.

What I don’t yet understand is why there are two names for each drug. Are both made up using the same kind of process ?

[chris37]

While I am no expert, I suspect one is the generic name, and the other the name brand.

Such as Valium/ diazepam, for instance.

[Steve Van Doorn]

I'm going through all your post to find what you're giving your patients.
You said, "we are using hydroxychloroquine and zmax sometimes vitamin c as well"

This isn't a study though Dr. Vladimir Zelenko with 700 patients with one fatality (April 3rd was the last update)
He suggests zinc is important.
https://techstartups.com/2020/04/03/updates-from-dr-vladimir-zelenko-now-treated-700-coronavirus-patients-with-99-9-success-rate-using-hydroxychloroquine-zinc-sulfate-and-z-pak-1-outpatient-died-after-not-following-protocol-exclusi/

This is this is preventative by Dr Lise Alschuler that is all over the counter. Base on Quercetin, zinc.
https://integrativemedicine.arizona.edu/file/72354/Integrative+Considerations+during+the+COVID+3.18.20.pdf

Personally I don't understand why Ascorbic Acid isn't given intravenously. Because SARS-Cov-2 attack the beta chain of Hemoglobin. Unstable hemoglobin creates heme cells that destroy nitric Oxide.

Viroprotein Orf3a attack the heme oxidizing the Iron in the beta chain and replace the iron. The heme can't carry oxygen without the Iron. Which also creates fibromyalgia and liver damage because of the high level of ferritin from the oxidized Iron.
Which is why hydroxychloroquine should work because it binds to the hemoglobin and neutralizes (alkaline) the Iron free heme. Macrophages require tons of asorbic acid to generate Nitric oxide which they used to create their oxidative burst.

COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
https://ravikollimd.com/resources/COVID/COVID-19__Attacks_the_1-Beta_Chain_of_Hemoglobin_and_Captures_the_Porphyrin_to_Inhibit_Human_Heme_Metabolism_v5.pdf

Thank you and good luck