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BREAKING: Tolicizumab (Actemra) shown to be more effective than hydroxychloroquine in treating coronavirus patients, Italian doctors say
Tech Startup ^ | March 27, 2020

Posted on 03/30/2020 10:53:40 PM PDT by aquila48

For the past two weeks now, we’ve been talking about hydroxychloroquine as the wonder drug in the fight against the deadly coronavirus. Two anti-malaria drugs hydroxychloroquine and chloroquine are shown to be effective in treating COVID-19 patients after controlled clinical study conducted by doctors ​in France shows that a combo of Hydroxychloroquine and Azithromycin (Z-Pak) cures 100% of coronavirus patients within 6 days of treatment.

However, according to doctors treating coronovirus patients in Italy, Tolicizumab, a drug used to treat moderate to severe rheumatoid arthritis, has been shown to be more effective than hydroxychloroquine. Tolicizumab is so effective that the FDA gives green lights to Phase III Tocilizumab Trial for COVID-19 pneumonia. In a related report, Italian doctors said that a 101-year-old Italian man who survived the 1918 Spanish flu pandemic and World War II, recovered from COVID-19.

In another report, scientists claim Tocilizumab has been shown to help cure 95 percent of critically ill coronavirus patients in China. Tocilizumab, which is marketed as Actemra, is taken by patients with rheumatoid arthritis to reduce inflammation. Chinese doctors gave it to 20 patients during the peak of of coronavirus epidemic. Nineteen of the patients were discharged within 14 days despite being critically ill. Actemra has now been approved for use in China and for trials in the US

In response to a question from another doctor on hydroxychloroquine, Dr. Giusppe Galati, an Italian doctor, said in a tweet: “Dear @DrLuizSilva1 despite the large noise on social media. Here in Flag of Italy they are trying several combinations of antiviral included the combination HCQ + azithro. Infectivologist refer little benefit. The unique drug which is causing impressive improvement is #Tolicizumab.”

Tocilizumab, also known as atlizumab, is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R).


TOPICS: Business/Economy; Culture/Society; Extended News; News/Current Events
KEYWORDS: actemra; beelzebubbuzz; belongsinbloggers; bloggers; braking; chinavirusdrugs; garbage; hcqzpac; moneygrab; tolicizumab; trash
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To: William Tell

My doc did a pharmacogenomics test on me to see how different drugs work on me. Some I already knew from taking them in the past. Ie: aspirin works well. I might as well drink water as take Tylenol. But there were some shockers in there. Plavix will not work on me and is usually the first drug given to avoid strokes. I could take it for years with it doing nothing. Psycho drugs won’t work well on me. If I go nuts I’ll just have to stay that way. lol A lot of it has to do with the way your body metabolizes the drugs. I think everyone should have the test. Would really help your doc in prescribing drugs or even classes of drugs.


101 posted on 03/31/2020 6:07:20 AM PDT by sheana
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To: chris37

the ending tells you what kind of biological it is. there are imabs and umabs. one is mouse and one is human but i forget which is which


102 posted on 03/31/2020 6:07:38 AM PDT by Mom MD
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To: Moonman62

It is being used off label but. sry difficult to come by


103 posted on 03/31/2020 6:09:45 AM PDT by Mom MD
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To: TigersEye

and doesn’t know how many people he haS treated even have covid. He is treating everyone with the sniffles


104 posted on 03/31/2020 6:11:42 AM PDT by Mom MD
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To: WWG1WWA

Thanks for your response re the Panexa article.
Made me go back and look at it.
Think reading it should be recommended for every Feeper, since “laughter is the best medicine”!


105 posted on 03/31/2020 6:12:27 AM PDT by milagro (There is no peace in appeasement!)
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To: Mom MD

Wow! Okay, thank you very much for that information. I had no idea.


106 posted on 03/31/2020 6:13:32 AM PDT by chris37 (Coronavirus wasn't born in a bowl of bat soup.)
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To: Bob434
Why do we have to wait for a clinical trial of Tolicizumab that could take months?

Because hydroxychloroquine is not patented and drug companies won't make money.

107 posted on 03/31/2020 6:14:36 AM PDT by PapaBear3625 ("Those who can make you believe absurdities, can make you commit atrocities." -- Voltaire)
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To: 9YearLurker

Bullspit. I never look at cost of a drug when figuring out what to use. If anything the pressure is to use the cheaper drug. I’m sick of the tinfoil around here


108 posted on 03/31/2020 6:15:39 AM PDT by Mom MD
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To: Buckeye McFrog

Haha :D


109 posted on 03/31/2020 6:16:16 AM PDT by chris37 (Coronavirus wasn't born in a bowl of bat soup.)
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To: Mom MD

I’m not talking about you or physicians in general.

Jeesh! Chill out before getting nasty.


110 posted on 03/31/2020 6:16:48 AM PDT by 9YearLurker
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To: Jim Noble; ZinGirl

Thank you both very much for educating me on this. I really appreciate the info, because I basically thought they were nonsense names, but they’re not.


111 posted on 03/31/2020 6:18:13 AM PDT by chris37 (Coronavirus wasn't born in a bowl of bat soup.)
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To: null and void

May I safely assume that “MERD Pharmeceutical Group” is a French company?


112 posted on 03/31/2020 6:19:08 AM PDT by MortMan (Shouldn't "palindrome" read the same forward and backward?)
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To: 9YearLurker

If you thought I was being nasty to you i apologize. The comment was to the predictable 150 comments about no one will use the cheap drug if there is an expensive one and all the follow the money comments. That is just not the way clinical practice works. However the newer and more expensive drugs often work better. We do learn things as we go along.


113 posted on 03/31/2020 6:24:18 AM PDT by Mom MD
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To: pepsionice

...usually for severe forms of arthritis.
++++++++++++++++++++++++++++++++++++++++++++++++++++++++

So, we now have a entire class of biologics and the HCQ regimen for COVID 19 that are also used for RA. Is there a connection between COVID 19 and rheumatoid arthritis?


114 posted on 03/31/2020 6:24:31 AM PDT by reformedliberal
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To: JoSixChip

Big Pharma/Chinese/Democrat propaganda.


115 posted on 03/31/2020 6:31:57 AM PDT by stinkerpot65 (Global warming is a Marxist lie.)
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To: Mom MD

I’m talking much higher up the chain, with the NIH, Big Pharma and what studies get funded, what miracle drugs get promoted. Not sure IIRC, but it seems as if you have been at some level involved in medical research, so you might fiercely defend against this, but it’s been shown pretty clearly. And Fauci tried to dismiss chloroquine when Trump brought it up—and fully funded lots of new drug studies.

It was actually Dr. Oz at Columbia who himself had to fund and get going the big study now in NYC.


116 posted on 03/31/2020 6:32:55 AM PDT by 9YearLurker
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To: 9YearLurker

big pharma will fund studies for their drugs of course. They cannot get approval without studies. I am grateful that they go to us to comeupwith new therapies. While I am not a fan of big pharma I do u defer and for every drug they spend billions bringing to market 9 more washout. Once the drug is on the market the lawyer sharks immediately start circling.

i have nothing to do with medical research. But the pressure is always to use a cheaper drug if two drugs do basically the same thing.


117 posted on 03/31/2020 6:41:55 AM PDT by Mom MD
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To: null and void

Lol.


118 posted on 03/31/2020 6:58:59 AM PDT by rdl6989
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To: JoSixChip
Just a quick check on GoodRx shows Tolicizumab ($1100) to Hydroxychloroquine ($20) is about 55x.

Every drug company in the world is hoping they can find that one of their patented drugs, for which they can charge an arm and a leg, can combat the CCP virus. Frankly, I'm amazed that word was allowed to leak out about Hydroxychloroquine, since it's cheap and unpatented.

119 posted on 03/31/2020 7:01:16 AM PDT by zeugma (I sure wish I lived in a country where the rule of law actually applied to those in power.)
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To: redgolum

“Another immune response inhibitor. Seems less about treating the virus then moderation of the immune response”

Yes, the virus itself may be relatively mild, but it makes the immune system go nuts.

I got a strong feeling that using a variety of immunodepressants is how this thing is going to be handled.

The big bonus is that having been infected you also become immune to it. So we may not have to wait for a vaccine.


120 posted on 03/31/2020 7:10:39 AM PDT by aquila48 (Do not let them make you care!)
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