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Drugs Aim to Make Several Types of Cancer Self-Destruct
NY Times ^ | December 22, 2012 | GINA KOLATA

Posted on 12/30/2012 12:24:38 AM PST by neverdem

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Extended News; News/Current Events; Testing
KEYWORDS: cancer; cancerdrugs; cancerselfdestruct; genetics; liposarcoma; p53
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To: B4Ranch

Yup. I have used nutritional remedies to deal with health problems; and in some instances, I found good leads by trolling through the NIH Pubmed database and pulling medical journal articles. Thanks for the link.


21 posted on 12/30/2012 11:28:01 AM PST by Rockingham
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To: kennyboy509

That is so good to hear.


22 posted on 12/30/2012 9:45:18 PM PST by There's millions of'em (Tis a relentless battle for freedom)
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To: neverdem

This is why health care competition is the best solution to our medical woes. The FedGov has the Constitutional authority through the Commerce Clause to end anti-competitive practices instituted by the states. Obamacare simply worsens the situation.

Most hospital systems are planning for a 60% cut in their Medicare payments. 60% cuts will kill patients and the system.


23 posted on 12/31/2012 4:01:18 AM PST by 1010RD (First, Do No Harm)
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