Not yet. I'm starting to see some impacts in the middle joint of my little finger. It's the spine, knees and ankles that are most annoying. During my daytime hours, I'm focused on work and can just endure the. Not so when I'm trying to sleep. I put down 4 x 200 mg ibuprofen about 30 minutes before hitting the rack so I can get to sleep.
A co-worker whose wife has all manner of auto-immune problems has reported good result with methotrexate. I simply haven't sought any treatment beyond OTC, but I know it is going to get ahead of me at some point.