A co-worker whose wife has all manner of auto-immune problems has reported good result with methotrexate. I simply haven't sought any treatment beyond OTC, but I know it is going to get ahead of me at some point.
That's not a small dose. OTC meds are not necessarily benign. They can be more than problematic.
I’ve been on Methotrexate for almost 17 yrs now and have tolerated it well. I’ve been getting an “experimental” drug that has helped me tremendously. It does something to the B cells which are what is causing my disease to at least be active. This drug has been approved for RA and will hopefully be approved for what I have soon.