[Mr Ramsbotham]

Supplemental vitamin D has been used for decades, and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse.

Gosh, all this time I thought it was smoking, drinking, overeating and a sedentary lifestyle.

[TChad]

Interesting.

[devere]

I am very skeptical of the theory propounded by this article. I take 2000 IU of vitamin D every day during the winter, and I haven’t missed a day’s work due to illness since November 1991. If my immune system is “suppressed”, it’s a surprise to me. Dr. J. J. Cannell reports that when an influenza epidemic swept through his mental hospital, only a ward of patients receiving daily 2000 IU vitamin D supplements were immune:
http://www.freerepublic.com/focus/f-chat/1929828/posts

The weakness of the Dr. Marshall’s theory is that it is based on speculative reasoning rather than sound epidemiology.

[freeangel]

Why do I get the feeling that this is “evidence” that the government would like in order to enact a new tax on vitamins?

[ThePythonicCow]

Trevor Marshall's home page is at: http://trevormarshall.com/ .

Note there is a link on it to the actual text of this paper, where it says:

New paper: Vit D discovery outpaces FDA decision making.
  FullText Preprint available here

---

Here's the contents of the Abstract for this paper, from one of the above links to Wiley InterScience:

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Vitamin D discovery outpaces FDA decision making

Trevor G. Marshall ^*

School of Biological Sciences and Biotechnology, Murdoch University, Western Australia

email: Trevor G. Marshall

^*Correspondence to Trevor G. Marshall, Autoimmunity Research Foundation, California Foundation, 3423 Hill Canyon Ave. Thousand Oaks, California 91360.

Abstract

The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoimmune disease, and infection. It does this by controlling the activation of the vitamin D receptor (VDR), a type 1 nuclear receptor and DNA transcription factor. Molecular biology is rapidly coming to an understanding of the multiplicity of roles played by the VDR, but clinical medicine is having difficulty keeping up with the pace of change. For example, the FDA recently proposed a rule change that will encourage high levels of vitamin D to be added to even more foods, so that the manufacturers can claim those foods reduce the risk of osteoporosis. The FDA docket does not review one single paper detailing the transcriptional activity of vitamin D, even though, on average, one new paper a day is being published on that topic. Nor do they review whether widespread supplementation with vitamin D, an immunomodulatory secosteroid, might predispose the population to immune dysfunction. This BioEssay explores how lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease. BioEssays 30:173-182, 2008. © 2008 Wiley Periodicals, Inc.

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Here's the contents of his home page, from another link above:

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TREVOR MARSHALL, PhD

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3423 Hill Canyon Ave,
Thousand Oaks, CA 91360, USA
phone: (805)492-3693

 

Click here for a List of Published Scientific Papers

Current Presentations:

New paper: Vit D discovery outpaces FDA decision making.
  FullText Preprint available here

'Metagenomics 2007', UCSD - Abstract Presentation, 11-13 July 2007

'Days of Molecular Medicine' - Abstract Presentation, 22-24 May, 2007

Lecture tour of Australian Universities:
"Molecular mechanisms driving the current epidemic of chronic disease"
   John Curtin School of Medical Research, Wed 15 Nov, 2:30pm
    Finkel Lecture Theatre, ANU
   The University of Melbourne, Thurs 16 Nov, 12 noon
     Bio21 Institute, Building 102, 30 Flemington Road

AAEM 2006 Annual Meeting - Faculty Presentation, Oct 27, 2006

Autoimmunity Research Foundation, 2006 Conference, June 17/18, 2006

Days of Molecular Medicine 2006, Stockholm, May 24-27, 2006

FDA CDER 'Visiting Professor' Presentation, March 7, 2006

"Recovering from Chronic Disease", Chicago, March 12/13, 2005

Quick Links:

List of Published Scientific Papers

Here are the details on the WiFi 802.11b/g Slotted Waveguide Antennas

Here are the details on the WiFi 802.11b/g Biquad Antenna/Primestar feed

Link to my website/repository for the NEC2 Antenna Simulators

Articles written for BYTE.com

---

Prof. Marshall is currently a Director of the Autoimmunity Research Foundation, an Adjunct Professor of the School of Biological Sciences and Biotechnology, Murdoch University (Western Australia), and a past Chair of the Engineering in Medicine and Biology Society of the Ventura IEEE. He is the Patron of the Australian Autoimmunity Foundation.

Based in the heart of Southern California's "Digital Coast", Dr. Marshall is involved in technologies ranging from Immunology, Biomedicine, Autoimmunity, WiFi Security and Internet Infrastructure through RF, Hardware, Software, Audio/Video and Prepress. Previous speaking engagements have included COMDEX, Microprocessor Forums, WLAN/WiFi conferences, and International presentations in a variety of Medical Specialties.

Pasteur once said "In science, chance favors the prepared mind," and Dr. Marshall's career has certainly taken advantage of the many twisty passages in the fields of both Medical Science and Engineering. The best way to find out what he is doing right now is to look at the list of current presentations (above) or browse his recently published scientific papers.

[A Navy Vet]

Just one more instance of science not knowing all. Here's some more:

Milk is bad - milk is good (calcium) and helps in weight loss; cheese is bad - cheese is a good source of protein; red meat is bad - red meat is an excellent source of protein; all fats are bad, but now they contribute to a mans health, vitality, and testosterone levels.
Cholesteral is bad (even though its naturally produced in the liver); now it's about triglycerides; sticky blood palets cause clots, but too thin blood causes internal bleeding and ulcers.

The planet is cooling in the 1970's; the planet is warming in the 2000's; recent reports are the planet temps have levelled off in the last 10 years.

Anyone remember alcore (sp) that almost decimated the apple industry back in the '70's? Turned out wrong.

Population growth will cause mass starvation world-wide. Didn't happen.

Remember themaldihide (sp) that was the dain of all of creation? Now they are using it for chem-therapy.

Pluto is one of the nine planets in our Solar Sytem; Pluto is no longer considered a planet.

The 2006 and 2007 hurricane seasons would be the worst on record due to global warming; the 2006 and 2007 hurricane seasons were relatively mild, again, due to global warming; the artic is melting - Greenland's ice sheet is building.

My all time favorite: Boys and Girls are born with the same blank slate and are a product of their upbringing and environment according to socialogists in the late "60's and early '70's. Flash forward a decade and Newsweek announces boys and girls have different mental make up. As if any parent can't see the obvious difference in their childrens' gender differences.

Here's some more from our oh-so-wise sages of early men of learning: Apollo rides sun-chariots around the World; the dead have to cross the river Styx; little civilization exists beyond Rome's empire; the Sun revolves around the Earth; go far enough to the West and you will fall off the planet; the Plaque was a god's revenge; earthquakes, volcanice eruptions, tornadoes, hurricanes were also god's revenge.

Lest I forget: Some ancient primitive persons wrote some books that was coalesced into what we know as the Bible. These were unknowlegable people of the time who thought a meteor in the sky was an Angel. They were the original flat-earth believers and had no understanding of the physics of the universe beyond their own simplistic viewpoints.

Almost every day our knowledge grows and finds our prior beliefs have been wrong. Even Einstein has been proven wrong according to some modern day physics. We are children in our understanding of the Universe and even our own Earthly history.

Bottom line: Scientific truth is ever changing. It is not absolute because we just don't know all. Vitamin D may be good...haha!. Then again, it may cause whales to uprise against mankind.

[Dr. Scarpetta]

*Ping

[Ladysmith]

Mark

[Harmless Teddy Bear]

and yet the epidemics of chronic disease, such as heart disease and obesity, are just getting worse."

Obesity is not a disease. Heart disease is but it is not getting worse.

At this point I quit taking anything in this article seriously.

[Scotswife]

get outside more folks!

[AmericanVictory]

Bump!

[Quix]

Not sure therefore what about this . . . Am suspicious that some powers that be don’t want Vit D helpfulness to be widely accepted.

Seems to me that the doc at the hospital that kept his wing free of influenza etc. with 2000 units daily of Vit D has it right.

[ThePythonicCow]

There is a more accessible explanation of all this at a site called Bacteriality.com, prepared by a young lady named Amy Proal. See for example the article Why the Marshall Protocol makes sense, posted Nov 28, 2007.

She does a good job of explaining these new insights into how our immune systems work, why recent evidence suggests that many chronic diseases have a bacterial cause, and how the Marshall Protocol works.

Admittedly, beginning with the very title of her article, she does little to persuade those who dismiss all this as "Marshall worship."

That's tough.

[Joya]

Thanks for posting this article, blam.

It’s the first I’m hearing of vitamin D receptor (VDR), I’d not heard before that VitD might be harmful instead of helpful.

HIGHLIGHT for myself:

‘The paper explains how the Vitamin D Nuclear Receptor (VDR) acts in the repression or transcription of hundreds of genes, including genes associated with diseases ranging from cancers to multiple sclerosis.

‘”The VDR is at the heart of innate immunity, being responsible for expression of most of the antimicrobial peptides, which are the body’s ultimate response to infection,” Marshall said.’

[CDHart]

One day it's good for you, and the next it isn't. Be nice if they'd make up their minds.

Carolyn

[Joya]

VitD might be harmful to people with autoimmune disease PING.

[Running On Empty]

Marking