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No Single Gene For Eye Color, Researchers Prove
Science Daily ^ | 2-25-2007 | University Of Queensland

Posted on 02/25/2007 4:34:29 PM PST by blam

University of Queensland
Date: February 25, 2007

No Single Gene For Eye Color, Researchers Prove

Science Daily — A study by researchers from The University of Queensland's Institute for Molecular Bioscience (IMB) and the Queensland Institute of Medical Research is the first to prove conclusively that there is no single gene for eye colour.

Says Dr. Rick Sturm, the IMB researcher who led the study: "... the model of eye colour inheritance using a single gene is insufficient to explain the range of eye colours that appear in humans. We believe instead that there are two major genes -- one that controls for brown or blue, and one that controls for green or hazel -- and others that modify this trait." (Credit: Image courtesy of University of Queensland)

Instead, it found that several genes determine the colour of an individual's eyes, although some have more influence than others.

“Each individual has two versions of a gene, inheriting one from each parent, and these versions can be the same as each other or different,” Dr Rick Sturm, the IMB researcher who led the study, said.

“It used to be thought that eye colour was what we call a simple Mendelian recessive trait - in other words, brown eye colour was dominant over blue, so a person with two brown versions of the gene or a brown and a blue would have brown eyes, and only two blues with no brown could produce blue eyes.

“But the model of eye colour inheritance using a single gene is insufficient to explain the range of eye colours that appear in humans. We believe instead that there are two major genes - one that controls for brown or blue, and one that controls for green or hazel - and others that modify this trait.

“So contrary to what used to be thought, it is possible for two blue-eyed parents to have a brown-eyed child, although this is not common.”

Dr Sturm likens the system to a light bulb.

“The mechanism that determines whether an eye is brown or blue is like switching on a light, whereas an eye becoming green or hazel is more like someone unscrewing the light bulb and putting in a different one.”

The study was carried out to clarify the role of the OCA2 gene in the inheritance of eye colour and other pigmentary traits associated with skin cancer risk in white populations, and examined nearly 4000 adolescent twins, their siblings and their parents over five years.

The findings are published in this month's edition of the American Journal of Human Genetics, and were supported with grants from Australia's National Health and Medical Research Council and the United States of America's National Cancer Institute.


TOPICS: News/Current Events
KEYWORDS: blueeyes; color; dna; eye; gene; helixmakemineadouble; mutation
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1 posted on 02/25/2007 4:34:32 PM PST by blam
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To: blam; SunkenCiv

"Very Clever, Grasshopper"

2 posted on 02/25/2007 4:36:52 PM PST by martin_fierro (< |:)~)
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To: martin_fierro

Gene, Gene The Dancing Machine must have something to do with this. (any Gong Show fans?)


3 posted on 02/25/2007 4:42:15 PM PST by 69ConvertibleFirebird (Never argue with an idiot. They drag you down to their level, then beat you with experience.)
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To: 69ConvertibleFirebird
na-na NAA na-nana! na-na NAA na-nana! Na-na NAA na-nana! Na-na NAA na-nana!

That dance alone was worth $516.32!

4 posted on 02/25/2007 4:45:55 PM PST by Tanniker Smith (A husband is what's left of a sweetheart after the nerve has been killed. -- Lou Costello)
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To: blam; patton

interesting...but...

i have brown eyes. my dad has brown eyes and my
mom has hazel eyes.

pat has blue eyes. his parents both have blue eyes.

all three of our kids have... blue eyes!

odd...


5 posted on 02/25/2007 4:46:31 PM PST by leda (The quiet girl on the stairs.)
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To: blam

IOW, that kid be yours after all.


6 posted on 02/25/2007 4:50:07 PM PST by decimon
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To: leda
After cataract surgery my eyes were noticeably deep blue rather than bright green as they had been since I was about 6 months old.

The surgery simply removed the pigment on the front of the lens.

They are returning to green although the formerly "black ring" is at present only a "brown ring".

I'd always thought it odd to see someone with one green eye and one blue eye. Now I know the secret.

Neither of my parents has green eyes. One has bright blue and the other brown. My kids have light hazel with a black ring ~ the ring didn't form until they were 9 or 10 years of age.

7 posted on 02/25/2007 4:57:57 PM PST by muawiyah
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To: leda

What dolor eyes did the mailman have? :)


8 posted on 02/25/2007 4:58:15 PM PST by 69ConvertibleFirebird (Never argue with an idiot. They drag you down to their level, then beat you with experience.)
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To: 69ConvertibleFirebird

mailman???

um, i'm the one with brown eyes. and trust me,
i was there. ;) the kids all have their daddy's
blue eyes.


9 posted on 02/25/2007 5:11:21 PM PST by leda (The quiet girl on the stairs.)
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To: muawiyah

wow, interesting!
i had laser surgery to correct my vision
about 8 yrs ago. i don't think my eye
color was affected tho.


10 posted on 02/25/2007 5:18:30 PM PST by leda (The quiet girl on the stairs.)
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To: leda

Did the postman ring once or twice?


11 posted on 02/25/2007 5:26:22 PM PST by bmwcyle (It is time to stop the left at the wall.)
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To: leda
Not odd, really. You are carrying a brown-eyed dominant gene from your dad and a blue recessive from your mom; therefore, your eyes are brown. Your hubby's two eye genes are both the blue recessive. When you made the kiddies, hubby contributed his one blue recessive and you passed on your blue recessive, therefore they all turned out with blue eyes. Had you contributed your brown dominant gene, kiddies would been brown-eyed.

Same situation in my family. Dad brown-eyed, Mom blue-eyed, but Dad carried a blue recessive gene. Of their six kids, only one...that would be me...came out with brown eyes. Four had blue eyes and one had hazel.

You are not alone! :-)

12 posted on 02/25/2007 5:26:38 PM PST by truthkeeper (It's the borders, stupid.)
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To: blam

13 posted on 02/25/2007 5:56:31 PM PST by UnklGene
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To: bmwcyle

Pardon, but my kids are MINE. No doubt there.


14 posted on 02/25/2007 5:57:11 PM PST by patton (Sanctimony frequently reaps its own reward.)
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To: truthkeeper

see, i've always thought that too, i'm not sure,
but i think the article said something different.
they compaired the genetics to a lightbulb. brown
eyes vs. blue eyes is one lightbulb and hazel/green
is a different lightbulb.


15 posted on 02/25/2007 6:09:47 PM PST by leda (The quiet girl on the stairs.)
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To: leda

Laser surgery should have no effect. Cataract surgery is much more robust. The eye is sliced further and the contents of the corneal sac are removed ~ the lens, debris, stuff, and pigment (if there was pigment in there).


16 posted on 02/25/2007 6:27:18 PM PST by muawiyah
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To: muawiyah

My eyes change color occasionally. Explain that one! No; I don't wear contact lenses.


17 posted on 02/25/2007 6:32:45 PM PST by Grizzled Bear ("Does not play well with others.")
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To: muawiyah

well, patton just peered at my peepers and said
they're the same eyes he's been looking at for
some 30 years or so. :)


18 posted on 02/25/2007 6:37:52 PM PST by leda (The quiet girl on the stairs.)
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To: Grizzled Bear
Let me guess:

1. Build up of heme in the bloodstream;

2. need for blood dialysis;

3. you're from Kentucky, named "Harris" and have blue skin (which is real ~ and treatable).

19 posted on 02/25/2007 6:38:28 PM PST by muawiyah
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To: blam

This is very interesting, thanks for posting. My eye color looks very much like the one in the center. Green with a dark outline and brownish around the pupil. But up until I was about 9 they were a deep blue with the dark outline. Curiously, both my parents have/had blue eyes, my mother's were very startlingly light blue, and 3 of my grandparent's had brown eyes. My mother's parents both had brown with flecks of green. My siblings have blue and gray eyes.


20 posted on 02/25/2007 6:50:34 PM PST by fortunecookie (My computer is back!)
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