Which is why the best trained assassins like those in MOSSAD use a .22 with a small "Hushpuppy" aka "can" aka suppressor hung on the end. Okay, you're accurate at the range when you have all the time in the world to aim and there's no stress.
But do the same thing under a time constraint of drawing and firing the weapon from a concealed holster within 2 seconds including the draw, against a target 15 feet away. Can you hit the eyeball everytime? Next do it while somebody also sounds a shrill whistle in your ear or drops a string of firecrackers behind you without your foreknowledge of the event.
It's easy on the range, but when it's life and death maybe the deaths of somebody you love a whole lot...well you just want all the stopping power you can find and shoot to center mass all the time. That translates down to a .45.