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"'And the wine failing, the mother of Jesus saith to him:They have no wine.
And Jesus saith to her: Woman, what is that to me and to thee? my hour is not yet come.
His mother saith to the waiters: Whatsoever he shall say to you, do ye.'
*Mary was nagging, huh?"

Yep.
Telling her son to perform a miracle, and not taking no for an answer.
Mama (giving "the look" to her boy): They're out of wine!

Son (seeing "the look" and knowing what she wants, irritatedly): Why's that OUR problem, woman? [The "woman" bit to his mother is certainly sharp!] And anyway, I'm not supposed to DO public miracles yet, it's not my TIME yet!"

Mama (completely ignoring everything her son has just said, addressing the help): "Do whatever he tells ya!"

Yeah. Nagging.
Mary's the only person in the Bible who ever demanded God do something God said he DIDN'T WANT TO DO, ignored God's response, and then God gave in and did it anyway.
The relationship between God and his mother is very interesting, as is the relationship between any son and his mother.
Right in this little passage, with Mary sort of pushing her boy around in public a little bit, we get a tiny glimpse as to why it is NOT a brilliant idea for anybody to go shooting off his lip about God's mother. God chose Mary as His bride, and to be his own mother, to raise him, nurse him, and be with him to the very end. So whatever her theological significance, she was evidently terribly significant to GOD, His favorite. God had twelve apostles and many prophets, but only ONE mother.

I would respectfully tell our Protestant friends to think, hard, about what they can possibly gain by going hammer and tongs after Mary the way some of them do. God chose this woman above all others. Sure, Jesus said that John the Baptist was greater than all other MEN, but Mary wasn't a man. Catholics shouldn't dig at Protestants too much to bend the knee to Mary. There are too many more important things to worry about. Still, in the interest of everybody's long-term well-being, I would advise a LITTLE BIT of caution, at least, in talking about God's mom.

Nobody likes people who pick on their mom.
What margin is there for anyone, then, on picking on Jesus' mother?
Just seems like a bad idea.
Just seems like one of those things that can at best result in a Pyrrhic Victory.
Especially since God evidently thinks highly enough of his mother to make HER the subject of visions and healings unlike anywhere else at Lourdes.
What BETTER proof of Mary's special relationship to God than the fact that there's no Protestant, or Jewish, or Muslim or Hindu Lourdes? And there's no Lourdes of St. Luke or St. John the Baptist either.

Mary tells Jesus what to do at Cana. He doesn't LIKE IT (his language is correct but impatient and not polite), but he follows the commandment, honors his mother for a command performance miracle, and amazes his friends, thereby launching his preaching career.

Lots of lessons here.
Best one is: be nice about Mary.
If your doctrine takes you in a direction where you're tearing down God's mom, be superstitious and don't do it, for your own good. Nobody's going to get a cookie at judgment from God for insulting his mother.