Nicotine By-product Reduces Alzheimer's Telltale Plaques

Scientific American ^ | June 17, 2003 | Sarah Graham

[tdadams]

The downsides of smoking are plentiful, ranging from stained fingers and teeth to an increased risk of lung cancer. But one potential upside was discovered recently when research suggested that cigarette smoking may delay the onset of Alzheimer's disease. Findings published online this week by the Proceedings of the National Academy of Sciences indicate that nornicotine, a by-product of nicotine, could be responsible for this protective effect.

Kim Janda and Tobin Dickerson of the Scripps Research Institute tested the effect of nornicotine on amyloid beta proteins, which aggregate into the plaques that are a hallmark of Alzheimer's disease. Specifically, the researchers found that a reaction known as glycation, which occurs between the molecule and sugars, alters amyloid proteins so that fewer plaques can form. The authors note that together with nicotine, nornicotine is an intriguing and potentially valuable treatment for Alzheimer's disease. Both compounds are toxic, however, so the scientists suggest investigating new therapies that can mimic their beneficial results without harmful side effects.

[Just another Joe]

Thanks for your concern. Not sarcasm, I appreciate true concern from anyone.
This isn't about whether smoking can cause harm to the smoker, although I think that's coming eventually to a statehouse somewhere. We all know that smoking is a risk factor for the smoker. This is about property rights and libertys.
I could give up smoking if I truly wanted to. I refuse to give up property rights for no reason other than someone doesn't like a particular smell.

[Humidston]

>>I refuse to give up property rights for no reason other than someone doesn't like a particular smell.<<

I couldn't agree more and believe me, when I'm out in public I actually prefer the company of smokers and enjoy sitting close by.

And I understand your frustration completely. It wasn't long ago that I was in your shoes - fending off attacks from those "pure" people who sneered at me for smoking IN SMOKING AREAS. (In fact I have some really funny stories about that!)

But all I'm saying is please be careful. Get a chest x-ray EVERY dang year so you can keep a close eye on those organs that sustain you. Breathing is essential. ;-)

[Just another Joe]

Thanks, I have a full checkup every year including stress test on the treadmill.