[null and void]

Phenylephrine is a very potent vasoconstrictor when given intravenously.

But destroyed in the gut.

How well would a nasal spray or sublingual/buccal work, I wonder...

[Getready]

If it is absorbed well through that way, it might cause dangerous rise in bp.(potential for stroke, MI...Plus it’s other side effects could exacerbate high blood sugars, decrease urine flow with prostatic hypertrophy.
Knowing the drug cultures unending search for a cheap high...those methods might already be being used...( Grind up the tabs and inhale it). Or inject it...very dangerous.

[Getready]

In have read that about 38% of an oral dose of phenylephrine is absorbed ....so some of it gets through the gut wall and liver destruction of it. Absorbed erratically.
But...”it doesn’t work”?...carefully constructed misinformation from the losers in the media..

[Myrddin]

Oral pseudoephedrine is a very effective nasal decongestant. Oral diphenhydramine (Benedryl) is an effective antihistamine. Topically applied phenylephrine (nasal spray) is an effective nasal decongestant. I suspect it is less or ineffective taken orally.

There was a time-release pseudoephedrine with 120 mg per tablet. It nicely shutdown my chronic nasal drainage. I was pleased with that, but failed to notice that I was putting in 21 hour days with ease. The cheap source of that time-release version went away. It was too expensive to purchase the smaller packages. I found out the hard way that stopping it cold turkey wasn't pleasant. It took 3 months to get the brick off my head while gagging on the nasal drainage that returned. I only take pseudoephedrine when necessary now. Very rarely.