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Effects of Aging Have Been Reversed by Putting Young Mouse Poop in Old Mice
Science alert.com ^ | May 6, 2022 | David Nield

Posted on 05/06/2022 9:42:13 AM PDT by House Atreides

It sounds like something that might have come out of a sci-fi novel, but it's based on cold, hard, printed research: transplanting fecal microbes from young mice into old mice seems to reverse key signs of aging in the guts, eyes, and brains of the older animals.

Further experiments showed that it works the other way too – moving microbes from the poop of aged mice into younger mice caused the younger animals to then show signs of aging, including increased inflammation in the brain and a reduction in a key protein needed for normal vision.

It's by no means a recipe for eternal youth, but as we get older we naturally become more susceptible to wear, tear, and disease – in part due to the way our guts degrade. These experiments show that something could be done about that, although only mice guts have been tested so far.

"Here, we tested the hypothesis that manipulating the intestinal microbiota influences the development of major comorbidities associated with aging and, in particular, inflammation affecting the brain and retina," write the researchers in their published paper.

Increased inflammation around the brain and the retinas in the eyes tends to happen as we get older, while age-related chronic inflammation – called 'inflammaging' – has been linked to specific immune cells.

When the poo microbes were transferred from young to old mice, this inflammation showed signs of reversing. When the transplant was moved the other way, signs of gut aging and inflammation began to appear in the younger mice.

These signs included a loss of integrity in the gut lining (so bacteria could pass into the blood), elevated levels of proteins associated with retinal degeneration, and the over-activation of the immune cells that are tied to inflammaging.

"Our results demonstrate that the age-associated changes in the murine intestinal microbiota contribute to disrupted gut barrier integrity and systemic and tissue inflammation affecting the retina and the brain, but these changes can be reversed by replacement with young donor microbiota," write the researchers.

Scientific studies are giving us more and more of an understanding about all the different ways that our gut microbes are linked to our health – whether that's mental health issues such as anxiety or physical health issues like obesity.

In other words, the mix of bacteria in our bellies really matters, and changing that mix – whether through diet or fecal transplants – has the potential to bring about a variety of different health benefits.

Now there's another option worth exploring for researchers. Future studies are planned to look at how long the positive impacts of these fecal transplants might last for, and which gut microbes in particular are controlling the effects that are being seen. Then, scientists can start to explore whether it could work in humans too.

"This ground-breaking study provides tantalizing evidence for the direct involvement of gut microbes in aging and the functional decline of brain function and vision and offers a potential solution in the form of gut microbe replacement therapy," says gut biologist Simon Carding, from the University of East Anglia in the UK.

The research has been published in Microbiome.


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: aging; reversal
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Wow! I wonder where we could find a physician agreeable to doing for us a fecal transplant of poo from young mice. /sarc
1 posted on 05/06/2022 9:42:13 AM PDT by House Atreides
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To: House Atreides

Brings a whole new meaning to ESAD.


2 posted on 05/06/2022 9:43:33 AM PDT by lightman (I am a binary Trinitarian. Deal with it!)
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To: House Atreides

So, “Sh!t for brains” is a GOOD thing…


3 posted on 05/06/2022 9:44:25 AM PDT by jagusafr ( )
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To: House Atreides

Is this the equivalent of Mickey getting a copyright extension every few years?


4 posted on 05/06/2022 9:44:39 AM PDT by KarlInOhio (If Hitler invaded Hell, I would make at least a favourable reference of the Devil...-Churchill)
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To: House Atreides
I guess all along we've just been symbionts like the Trill.

Whatever happened to Dax?

5 posted on 05/06/2022 9:44:44 AM PDT by who_would_fardels_bear (This is not a tagline.)
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To: House Atreides

I never imagined being full of ____ was the fountain of youth.


6 posted on 05/06/2022 9:45:21 AM PDT by DannyTN
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To: KarlInOhio

LOL. Disney: The Lobbyist Place on Earth!


7 posted on 05/06/2022 9:45:27 AM PDT by who_would_fardels_bear (This is not a tagline.)
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To: House Atreides

These researchers really know their sh!t...


8 posted on 05/06/2022 9:45:53 AM PDT by Yo-Yo (Is the /Sarc tag really necessary? Pray for President Biden: Psalm 109:8)
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To: House Atreides

Amber Heard should invest in a Poop Bank.

She can make deposits too.

I mean since her acting career is over.


9 posted on 05/06/2022 9:46:36 AM PDT by David Chase
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To: House Atreides

This could be important.

(Many biomedical discoveries begin in animal research. Most of us are probably taking, or have taken, a pharmaceutical or treatment that began that way.)


10 posted on 05/06/2022 9:47:16 AM PDT by Jamestown1630 ("A Republic, if you can keep it.")
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To: House Atreides

I guess this means the phrase “Eat S*it and Die” is totally inaccurate.


11 posted on 05/06/2022 9:47:33 AM PDT by GreenHornet
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To: House Atreides

This treatment has been floating around for years.......

One in a long list of studies regarding gut health....


12 posted on 05/06/2022 9:50:34 AM PDT by nevergore (I have a terrible rash on my covfefe....)
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To: House Atreides

[[ Then, scientists can start to explore whether it could work in humans too]]

Where has the writer been? Theynhave been doing fecal transplants for awhile now. There shoukd be plenty of evidence whether it works or not. It’s reported to help folks with intestinal diseases like crow’s and colitis. I think with ulcers too. Heck you can buy fecal transplant pills online for it.


13 posted on 05/06/2022 9:51:11 AM PDT by Bob434 (.)
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To: DannyTN

I haven’t aged in many decades


14 posted on 05/06/2022 9:52:12 AM PDT by Bob434 (.)
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To: Bob434

I’ve been telling people I look young for my age due to innocent living. Turns out it was something else altogether!


15 posted on 05/06/2022 9:53:16 AM PDT by DannyTN
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To: nevergore

This may explain why Democrats/GROOMERS act like spoiled little immature BRATS! I just generally thought they were full of POO. This study seems to suggest THEY ARE !!!!


16 posted on 05/06/2022 9:54:06 AM PDT by OHPatriot (Si vis pacem, para bellum)
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To: who_would_fardels_bear

They didnt survive. One simbiont called, Suzanne Sommers talked all.the other simbionts into exercising for better health, and unfortunatle,y they all tried it, and began running around until they were all pooped out.


17 posted on 05/06/2022 9:55:44 AM PDT by Bob434 (.)
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To: House Atreides

Quick, we need to get some young people to put some poo in Joe. Any volunteers?


18 posted on 05/06/2022 9:59:34 AM PDT by jacknhoo ( Luke 12:51; Think ye, that I am come to give peace on earth? I tell you, no; but separation.)
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To: jacknhoo

Not enough mouse poo in the world to help joe.


19 posted on 05/06/2022 10:02:19 AM PDT by farmguy
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To: House Atreides

Maybe “Eat shi$ and die” was not settled science!


20 posted on 05/06/2022 10:02:40 AM PDT by Erik Latranyi (We are being played by forces most do not understand)
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