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mRNA vaccines: Why is the biology of retroposition ignored?
Researchgate ^ | Tomislav Domazet-Lošo

Posted on 12/08/2021 2:56:03 PM PST by Triple

The major advantage of mRNA vaccines over more conventional approaches is their potential for rapid development and large-scale deployment in pandemic situations. In the current COVID-19 crisis the two mRNA COVID-19 vaccines have been conditionally approved and broadly applied, while others are still in clinical trials. However, there is no previous experience with the use of mRNA vaccines on the large scale in general population.

This warrants a careful evaluation of mRNA vaccine safety properties by considering all available knowledge on the mRNA molecular biology and evolution. Here, I discuss the pervasive claim that mRNA-based vaccines cannot alter genomes. Surprisingly, this notion is widely stated in the mRNA vaccine literature, but never supported by referencing any primary scientific papers that would specifically address this question. This discrepancy becomes even more puzzling if one considers previous work on the molecular and evolutionary aspects of retroposition in murine and human populations that clearly documents the frequent integration of mRNA molecules into genomes, including clinical contexts. By performing basic comparisons, I showed that the sequence features of mRNA vaccines meet all known requirements for retroposition by L1 elements — the most abundant autonomously active retrotransposons in the human genome. In contrast, I found an evolutionary bias in the set of known retrocopy generating genes — a pattern that might help in the future development of retroposition-resistant therapeutic mRNAs.

I conclude that is unfounded to a priori assume that mRNA-based therapeutics do not impact genomes, and that the route to genome integration of vaccine mRNAs via endogenous L1 retroelements is easily conceivable. This implies that we urgently need experimental studies that would rigorously test for the potential retroposition of vaccine mRNAs. At present, the insertional mutagenesis safety of mRNA-based vaccines should be considered unresolved.


TOPICS: Business/Economy; Culture/Society; News/Current Events
KEYWORDS: flunkedbiology101; followthemoney; learnwhatmrnais; mrna; vaxlies
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More vax lies exposed.

The biology is clear. mRNA gene therapy can alter your genetics. It is not just purely transitory.

1 posted on 12/08/2021 2:56:03 PM PST by Triple
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To: Triple
Related...

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

...Mechanistically, we found that the spike protein localizes in the nucleus...

Okaaaay....

2 posted on 12/08/2021 3:01:49 PM PST by mewzilla (Those aren't masks. They're muzzles. )
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To: ransomnote

Ping


3 posted on 12/08/2021 3:02:59 PM PST by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)
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To: Triple

their ONLY advantage is profit.

NO ONE KNOWS the final impact of changing DNA.

and BIOpharma, the CDC, and the FDA, could not care less.
THEY are not taking the “VAX”-rapes themselves, anyway.


4 posted on 12/08/2021 3:04:13 PM PST by Diogenesis (Si vis pacem, para bellum)
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To: Triple
"However, there is no previous experience with the use of mRNA vaccines on the large scale in general population."

Fauci: "So let's force the whole world to be vaccinated and see what happens!!"
5 posted on 12/08/2021 3:04:34 PM PST by Steve_Seattle
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To: Triple
mRNA gene therapy can alter your genetics.
Does this mean that someday I can finally play a banjo?
6 posted on 12/08/2021 3:08:26 PM PST by dblshot
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To: Triple
I'm a pureblood


7 posted on 12/08/2021 3:09:28 PM PST by Pollard (PureBlood -- youtube.com/watch?v=VXm0fkDituE)
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To: Steve_Seattle

That is it in a nutshell.


8 posted on 12/08/2021 3:10:45 PM PST by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)
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To: Triple

I had the jabbs 10+ months ago. My energy levels and libido are enhanced, so I welcome the genetic changes.


9 posted on 12/08/2021 3:11:10 PM PST by entropy12 (President Trump was the best president in my life time of 81 years and counting..)
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To: Triple

Why does he assume these studies have not been done? The Covid vaccines are new, but mRNA vaccines have been tested for over 20 years. None of those tests found any genomic issues.


10 posted on 12/08/2021 3:11:12 PM PST by Renfrew
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To: dblshot

You know how to get to Carnegie hall…

Practice, practice, practice


11 posted on 12/08/2021 3:11:57 PM PST by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)
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To: Diogenesis

You’re correct but beside profit is the element of control…money and power are always central when something doesn’t “make sense”.


12 posted on 12/08/2021 3:12:40 PM PST by mikelets456
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To: Triple

The effect of all of the poisons labeled COVID vaccines is to flood the bodies of the people injected with a version of the Baric-Daszak-Fauci spike protein.

The Baric-Daszak-Fauci spike protein, by itself, is deadly.

It is, amongst other things, like a skeleton key that can invade every part of the body.

Every cell.

Every system.

It will cause severe damage in millions of people.

For some, the effects will become apparent quickly.

For others, the effects will build over time.


13 posted on 12/08/2021 3:13:34 PM PST by Arcadian Empire (The Baric-Daszak-Fauci spike protein, by itself, is deadly.)
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To: Steve_Seattle

At least 234,269,053 people or 71% of the population have received at least one dose.

I have not seen anyone dropping dead in streets in spite of that humongous sample size (MORE THAN THREE TIMES BIGGER than votes president Trump received in either run).

https://usafacts.org/visualizations/covid-vaccine-tracker-states/


14 posted on 12/08/2021 3:14:08 PM PST by entropy12 (President Trump was the best president in my life time of 81 years and counting..)
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To: Triple

A lot of your big pharma companies are led by people who have no problem at all hurting others. In fact, there is quite a recorded history of pharma companies doing things that were plainly wrong and harmful, bribing government officials and covering up their crimes.


15 posted on 12/08/2021 3:14:36 PM PST by hopespringseternal
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To: Renfrew

Were they effective though? They tested on Ebola with no conclusion. I simply don’t trust anything that has been pushed in such a way as these vaccines. Hiding side effects, deaths and other symptoms is cause for concern.


16 posted on 12/08/2021 3:14:54 PM PST by mikelets456
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To: Renfrew

He does not assume…he knows.

Please post your 20 year history of mRNA “vaccines.”

Hint: these spike protein mRNA jabs are the FIRST. It is a fact.

Or - just post the manufacturer and disease of the first mRNA “vaccine.”


17 posted on 12/08/2021 3:15:04 PM PST by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)
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To: Renfrew

Why are you trying to educate so many ill-informed posters?


18 posted on 12/08/2021 3:15:16 PM PST by entropy12 (President Trump was the best president in my life time of 81 years and counting..)
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To: Renfrew

*Authorized for use in humans.


19 posted on 12/08/2021 3:17:13 PM PST by Triple (Socialism denies people the right to the fruits of their labor, and is as abhorrent as slavery)
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To: Triple

There have been several studies on this that showed integration of the mRNA into the human genome in cultured cells. Endogenous reverse transcriptase made this possible.

However one of the criticisms of the publication was that it relied on overexpression of human reverse transcriptase.

So for right now we can count this as a possibility but it needs to be confirmed in vivo.

The experimental group now is very large, so a whole genome microarray analysis MIGHT show integration, but one would have to know which cells would be the most likely to harbor the novel DNA.


20 posted on 12/08/2021 3:18:26 PM PST by packagingguy
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