Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model

NIH ^ | 2021 | NIH

[NoLibZone]

Abstract

Background: Post-vaccination myopericarditis is reported after immunization with COVID-19 mRNA-vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown.

Methods: We compared the clinical manifestations, histopathological changes, tissue mRNA expression and serum levels of cytokine/chemokine in Balb/c mice at different time points after intravenous(IV) or intramuscular(IM) vaccine injection with normal saline(NS) control.

Results: Though significant weight loss and higher serum cytokine/chemokine levels were found in IM group at 1 to 2 days post-injection(dpi), only IV group developed histopathological changes of myopericarditis as evidenced by cardiomyocyte degeneration, apoptosis and necrosis with adjacent inflammatory cell infiltration and calcific deposits on visceral pericardium, while evidence of coronary artery or other cardiac pathologies was absent. SARS-CoV-2 spike antigen expression by immunostaining was occasionally found in infiltrating immune cells of the heart or injection site, in cardiomyocytes and intracardiac vascular endothelial cells, but not skeletal myocytes. The histological changes of myopericarditis after the first IV-priming dose persisted for 2 weeks and were markedly aggravated by a second IM- or IV-booster dose. Cardiac tissue mRNA expression of IL-1β, IFN-β, IL-6 and TNF-α increased significantly from 1dpi to 2dpi in IV but not IM group, compatible with presence of myopericarditis in IV group. Ballooning degeneration of hepatocytes was consistently found in IV group. All other organs appeared normal.

Conclusions: This study provided in-vivo evidence that inadvertent intravenous injection of COVID-19 mRNA-vaccines may induce myopericarditis. Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.

Keywords: COVID-19; SARS-CoV-2; intramuscular; intravenous; mRNA vaccine; mouse model.

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

[bray]

Ivermectin cures it at near 100%.

[frogjerk]

Brief withdrawal of syringe plunger to exclude blood aspiration may be one possible way to reduce such risk.

Isn't the CDC's guidance on this the exact opposite?

[butlerweave]

Ivermectin is too simple and way too cheap plus the Dems would never get a nice cut like from Fake Vaccine

[DSH]

Isn't the CDC's guidance on this the exact opposite?

The CDC's position has been that the spike protein portion of the SARS-COV-2 virus is "harmless," so it must follow that it doesn't matter whether or not the mRNA in vaccine remains solely in the deltoid muscle tissue, or migrates through the body, right?

The real question is why does anybody listen to what the CDC says about anything?

[TTFX]

There are other components in the potion.

[bray]

Trump really got fooled on this one.

[Empire_of_Liberty]

My understanding, as a layperson, is that the spikes produced mostly remain attached to the cells creating them. The cells are attacked and destroyed by your immune system.

It’s hard to believe that it does not matter where this is occurring.

[vetvetdoug]

F’in stupid CDC. We always aspirate when giving any injection to prevent putting the vaccine or medicine into a vein or artery. Do physicians not do this? A vaccine IV is more likely to cause an anaphylactic reaction. IA is even more likely. Each day I realize that many in the human Medical community are troglodytes.

[ETCM]

If the problem was associated with intravenous injection vice intramuscular, the inflammation would occur equally between the 1st and 2nd dose. Instead, it is strongly associated with the second dose. The military study showed that all three servicemen that had the reaction after the first dose had verified previous COVID infections. It’s an immune reaction, a “hypersensitivity response”, and aspirating isn’t going to help.

https://jamanetwork.com/journals/jamacardiology/fullarticle/2781601

“Presentation after second vaccine dose or, in 3 patients, when vaccination followed SARS-CoV-2 infection, suggests that prior exposure was relevant in the hypersensitivity response.”

[taxcontrol]

And siince I already have a damaged heart, I will not be getting the vaccine.

[WildHighlander57]

Article came out in August of this year.

How long have they known of this problem?

[DSH]

My understanding, as a layperson, is that the spikes produced mostly remain attached to the cells creating them. The cells are attacked and destroyed by your immune system.

It’s hard to believe that it does not matter where this is occurring.

Right. So if the mRNA gets into the bloodstream and expresses the spike protein in endothelial tissue . . . well, that's potentially very bad news. Among other problems. Accordingly, we are meant to take it on faith that the mRNA does not migrate away from the deltoid muscle.

I mean, the long-term testing should indicate just how much of a problem this potential migration might be. Oh, wait . . . . That's why they have test pilots.

[HKMk23]

“Can”

A large enough asteroid “can” wipe out the Earth.

It’s NEVER about “can”; it’s ALL about “how often.”

[jacknhoo]

We have more human experiments than mice experiments. The ignorant and/or already subjugated public don’t care to hear the truth. These gene serums are evil.

[DoodleDawg]

Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model

Intravenous injection of most vaccines can cause heart problems. That's why they are administered in the upper arm where there is little chance of hitting a vein.

[ransomnote]

Someone lined up mRNA 'doses' by the number of micrograms per dose, and then compared how many micrograms of a dose resulted in how many deaths.

So Moderna has more micrograms per dose than Pfizer - and more deaths. We knew dose 2 resulted in more deaths than dose 1, I just hadn't considered that there is this kind of spread in dosage and deaths.

"We might then hypothesize that there is a relationship between cumulative dose of spike protein from mRNA (x) and fatality rate per million doses over 30 days (y)."

x = 30μg (Pfizer dose 1),

x = 60μg (Pfizer dose 1+2)

X = 100μg (Moderna dose 1)

X = 200μg (Moderna dose 1+2)

y (fatalities/1m doses)= 394/113, 710/113, 545/75.74, 767/75.74

When plotted we end up with this graph:

ransomnote: I'll add that I think it's Pfizer that had 'parasites' 

Taken from the following FR thread:

Spike Protein, a Dose Dependent Killer?
Medium ^ | 3 October 2021 | Kamal Mokeddem

Posted on 10/4/2021, 9:24:08 PM by Fractal Trader

[Gene Eric]

Good thing the FDA made sure BigPharma disclosed this minor detail.

[SiGeek]

I mean, the long-term testing should indicate just how much of a problem this potential migration might be. Oh, wait . . . . That's why they have test pilots.

Well we can always refer to the long-term testing of other mRNA vaccines approved in the years before Covid, right? /sarc

[FormerFRLurker]

Who injects a vaccine intravenously? Most vaccines are administered in the upper arm specifically to prevent hitting a vein. This study is flawed if that's what they're looking at.

Also, why experiment on cute, innocent, little mice when there are millions of humans who have already taken the vaccine? Rate of vaccine-related myocarditis in humans: 0.001%. I took a bigger risk with my life driving to and from the vaccination site than from the vaccine itself.
https://freerepublic.com/focus/f-chat/3985007/posts