Posted on 08/16/2021 1:00:41 PM PDT by Jan_Sobieski
Recently, INSERM researchers produced a peer review assessment with disturbing implications for those who keep an open mind to what could occur as the pandemic and mass vaccination programs unfold worldwide.
The France-based team of investigators cautions public health authorities, academia, and the pharmaceutical industry that risks are associated with current vaccination programs. That is, first and foremost, the team detects infection-enhancing antibodies in symptomatic COVID-19. But that also antibody-dependent enhancement (ADE) represents a concern for the current crop of vaccine products while enhancing antibodies recognize both the Wuhan (wild-type) as well as delta variant of interest. Moreover, they indicate that there is now a risk with current vaccines associated with ADE of delta variants, while finally, vaccine formulations should preclude ADE epitope.
Recently, three respected researchers from France’s INSERM sought to investigate the recognition of SARS-CoV-2 delta variants by infection-enhancing antibodies directed against the N-terminal domain (NTD)…
(Excerpt) Read more at trialsitenews.com ...
No. ADE leads to worse outcomes than those not previously exposed to another serotype. And it would be seen in those who were naturally infected as well as it has nothing to do with anything specific to vaccination.
Since outcomes are better among vaccinated persons who become infected and those previously infected who become reinfected - including with Delta - there cannot be ADE taking place.
Not sure if ADE is a problem or not. But am pretty damn sure that it is insanely irresponsible to push everyone to get the jab without long term studies of what all the problems might be, particularly after the vaers adverse reactions and deaths shot up past Pluto. Totally insane.
I've read the opposite, source please.
It’s false. ADE depends on the antibodies you have. People who had the virus develop antibodies for different parts of the virus. People who had a mrna injection and people who had the virus have a different mix of antibodies.
Isn’t ADE when you wreck your natural antibodies with some foreign agent that your antibodies take a shape that welcome the virus to the cell instead of blocking it?
In experiments where an injection caused ADE, ADE did not occur in the placebo group.
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~Easy
No, ADE happens when antibodies formed with one serotype of a virus aid in the infection process when they encounter another serotype. This is seen commonly with Dengue virus. A person becomes infected with one serotype of Dengue, recovers, and then gets exposed to another serotype of Dengue virus. What happens next is that what should normally be a pretty manageable infection suddenly becomes extremely dangerous.
It has nothing to do with “wrecking your natural antibodies with some foreign agent”. The antibodies aren’t altered in any way. The antigen is simply different in a precise way that causes the antibodies (which were produced for the other antigen) to assist in the infection rather than preventing it. It also doesn’t necessarily have anything to do with a vaccine. It most commonly happens without any vaccination at all in areas where multiple serotypes of a virus that can cause ADE (like Dengue) are present.
So now we move from Myocarditis to daily never ending post about ADE?
What’s up next for when this ADE thing gets tired and old?
Misleading. Both groups have antibodies to the S protein. Those who are infected also have antibodies to the N and M proteins. The 2012 paper on SARS ADE focused on antibodies for the N protein being the most likely source of any ADE problems. That's one of the main reasons why the S protein was the chosen target antigen for the vaccine candidates for SARS-CoV-2. It was specifically chosen to reduce the risk of ADE.
But since there's been no evidence of people experiencing ADE after initial infection, there's no evidence that anyone is experiencing ADE. This whole thing is nonsense fearmongering without a shred of evidence to support it.
Highlights
•Infection-enhancing antibodies have been detected in symptomatic Covid-19
•Antibody dependent enhancement (ADE) is a potential concern for vaccines
•Enhancing antibodies recognize both the Wuhan strain and Delta variants
•ADE of Delta variants is a potential risk for current vaccines
•Vaccine formulations lacking ADE epitope are suggested
Abstract
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered
You got it completely backwards, but thanks for playing.
Might? Maybe? Possibly?
You should go try your luck in the lottery. There’s been no evidence of any ADE in over 18 months of infections. None whatsoever. Reinfections appear milder; not more severe. The Democrats were better at fearmongering. This is just nonsense.
No, I don’t. Try reading some factual material before pontificating on subjects you know absolutely ZERO about.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573563/
Carry on.
Correct. You bloviate about a subject you know nothing of. Try to stop being such a transparent government stooge (Rand Corp. "influencer"?).
No
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