Posted on 07/13/2021 6:36:06 AM PDT by Red Badger
A recent study by Kansas State University virologists demonstrates successful postinfection treatment for SARS-CoV-2, the virus that causes COVID-19.
College of Veterinary Medicine researchers Yunjeong Kim and Kyeong-Ok “KC” Chang published the study in the prestigious journal Proceedings of the National Academy of Sciences of the United States of America, or PNAS. They found that animal models infected with SARS-CoV-2 and treated with a deuterated protease inhibitor had significantly increased survival and decreased lung viral load.
The results suggest that postinfection treatment with inhibitors of proteases that are essential for viral replication may be an effective treatment against SARS-CoV-2. These protease inhibitors are a class of antiviral drugs that prevent viral replication by selectively binding to viral proteases and blocking the activation of proteins that are necessary for the production of infectious viral particles.
“We developed the protease inhibitor GC376 for treating a fatal coronavirus infection in cats, which is now under commercial development as an investigational new animal drug,” said Kim, associate professor of diagnostic medicine and pathobiology. “After COVID-19 emerged, many research groups reported that this inhibitor is also effective against the coronavirus that causes COVID-19, and many are currently pursuing the development of protease inhibitors as a treatment.”
Kim and Chang modified GC376 using a tool called deuteration to test its efficacy against SARS-CoV-2.
“Treating SARS-CoV-2-infected mice with deuterated GC376 significantly improved survival, viral replication in lungs, and weight losses, which shows the efficacy of the antiviral compound,” said Chang, professor of diagnostic medicine and pathobiology. “The results suggest deuterated GC376 has a potential for further development, and this deuteration method can be utilized to other antiviral compounds to generate potent inhibitors.”
The virologists are continuing to develop improved inhibitors using various methods. Deuterated GC376 is currently being evaluated for further potential development.
Previous work done by Kim and Chang is continuing development through licensing agreements with industry partners.
Reference: “Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection” by Chamandi S. Dampalla, Jian Zheng, Krishani Dinali Perera, Lok-Yin Roy Wong, David K. Meyerholz, Harry Nhat Nguyen, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Yunjeong Kim, Stanley Perlman, William C. Groutas and Kyeong-Ok Chang, 1 July 2021, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2101555118
If any treatment were to be acknowledge then the entire “vaccine” push would collapse. That will not be allowed to happen.
The new and improved “protease inhibitor resistant” Fauci Flu variant is scheduled for release in September....
My mice are all cheering.
If a treatment works, experimental jabs may not be given, by law.
Mice and cats can be infected with SARS-CoV-2? Where am I going to find masks that small?
From here on out?
What percentage of medications produced by Big Pharma include mRNA or DNA fragments? The technology has totally unproven safety assurance.
This will not end well.
After giving the new treatment, they better be sure the cats and mice survive the real virus.
If this was a Hollywood horror movie script it would not be believable..................
That is true. But this is real.
And it is not a subject that will be openly talked about by the news, our elected officials or Fed/State Bureaucraps.
Did you see the 2013 zombie movie “World War Z” starring Brad Pitt?.......... This is almost the plot!............
https://en.wikipedia.org/wiki/World_War_Z_(film)
https://www.imdb.com/title/tt0816711/
Maybe someone should tell Trump so he can stop pushing the jab.
Right. That’s why we are using monoclonal antibodies, steroids, remdesivir, tolicizumab and other treatments. gotcha
No. I did not. But I don’t watch TV and very seldom go to the movies. Last time I went to a movie, my wife and I took her grand daughter to one she wanted to watch. Special effects were great, movie was a real dud.
It was about a virus that accidentally escaped from a WHO Lab and turns people into zombies........................
RE: They found that animal models infected with SARS-CoV-2 and treated with a deuterated protease inhibitor had significantly increased survival and decreased lung viral load.
We already have cures for cancer in mice. Now they have a cure for SARS-COV-2 in animals.
Well, good news if you’re an animal.
Excellent progress. Such virus-specific anti-proteases could be developed for just about any virus, and would be faster acting than any kind of vaccine.
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