Posted on 05/09/2021 7:18:59 PM PDT by Triple
We asked experts to help us decode the contents. by Antonio Regalado December 9, 2020
Facebook said on December 3 that it would remove posts with false claims or conspiracy theories about what’s in the covid-19 vaccines that everyone’s counting on.
In the face of rumors suggesting that Bill Gates has installed tracking microchips in the shots, or that the inoculations contain luciferase, a glowing chemical from fireflies whose name makes some people think of the devil, the company suggested it would be policing such claims by making reference to the “official vaccine ingredient list.”
What’s actually on the official ingredient list? This week an elderly UK woman became the first person outside of a trial to get the newly approved vaccine developed by Pfizer and BioNTech, and the US could greenlight the same inoculation as soon as Thursday, December 10. Along with the regulatory actions over the last week have come the most detailed disclosures yet of the new vaccine’s makeup.
Here, for instance, is what the US Food and Drug Administration says is in Pfizer’s vaccine:
Active Ingredient nucleoside-modified messenger RNA (modRNA) encoding the viral spike glycoprotein (S) of SARS-CoV-2 Lipids (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis (ALC-3015) (2- hexyldecanoate),2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159) 1,2-distearoyl-snglycero-3-phosphocholine (DPSC) cholesterol
Salts potassium chloride monobasic potassium phosphate sodium chloride basic sodium phosphate dihydrate
Other sucrose
Reading the ingredient list is like looking at the side of a cereal box, except that you need a degree in organic chemistry to understand it. We got help from various scientists and biotech entrepreneurs to understand what each of the ingredients does and make some educated guesses about others.
The mRNA
Pfizer’s vaccine is the first on the market that consists of actual genetic information from a virus in the form of messenger RNA, or mRNA, a type of molecule whose usual job is to transport copies of genetic instructions around a cell to guide the assembly of proteins. Imagine an mRNA as a long ticker tape carrying instructions. It’s fairly delicate stuff, and that’s why Pfizer’s vaccine needs to be kept at around -100 °F (-73 °C) until it’s used.
The new vaccine, delivered as a shot in the arm muscle, contains an RNA sequence taken from the virus itself; it causes cells to manufacture the big “spike” protein of the coronavirus, which the pathogen uses to glom onto a person’s cells and gain entry. On its own, without the rest of the virus, the spike is pretty harmless. But your body still reacts to it. This is what leaves you immunized and ready to repel the real virus if it turns up.
The mRNA in the vaccine, to be sure, isn’t quite the same as the stuff in your body. That’s good, because a cell is full of defenses ready to chop up RNA, especially any that doesn’t belong there. To avoid that, what’s known as “modified nucleosides” have been substituted for some of the mRNA building blocks.
But Pfizer is holding back a little. The spike gene sequence can be tweaked in small ways for better performance, by means that include swapping letters. We don’t think Pfizer has said exactly what sequence it is using, or what modified nucleosides. That means the content of the shot may not be 100% public.
The lipids
The Pfizer vaccine, like one from Moderna, uses lipid nanoparticles to encase the RNA. The nanoparticles are, basically, tiny greasy spheres that protect the mRNA and help it slide inside cells.
These particles are probably around 100 nanometers across. Curiously, that’s about the same size as the coronavirus itself.
Pfizer says it uses four different lipids in a “defined ratio.” The lipid ALC-0315 is the primary ingredient in the formulation. That’s because it’s ionizable—it can be given a positive charge, and since the RNA has a negative one, they stick together. It’s also a component that can cause side-effects or allergic reactions. The other lipids, one of which is the familiar molecule cholesterol, are “helpers” that give structural integrity to the nanoparticles or stop them from clumping. During manufacturing, the RNA and the lipids are stirred into a bubbly mix to form what the FDA describes as a “white to off-white” frozen liquid.
Salts
The Pfizer vaccine contains four salts, one of which is ordinary table salt. Together, these salts are better known as phosphate-buffered saline, or PBS, a very common ingredient that keeps the pH, or acidity, of the vaccine close to that of a person’s body. You’ll understand how important that is if you’ve ever squeezed lemon juice on a cut. Substances with the wrong acidity can injure cells or get quickly degraded.
Sugar
The vaccine includes plain old sugar, also called sucrose. It’s acting here as a cryoprotectant to safeguard the nanoparticles when they’re frozen and stop them from sticking together.
Saline solution
Before injection, the vaccine is mixed with water containing sodium chloride, or ordinary salt, just as many intravenously delivered drugs are. Again, the idea is that the injection should more or less match the salt content of the blood.
No preservatives
Pfizer makes a point of saying its mixture of lipid nanoparticles and mRNA is “preservative-free.” That’s because a preservative that’s been used in other vaccines, thimerosal (which contains mercury and is there to kill any bacteria that might contaminate a vial), has been at the center of worries around over whether vaccines cause autism. The US Centers for Disease Control says thimerosal is safe; despite that, its use is being phased out. There is no thimerosal—or any other preservative—in the Pfizer vaccine. No microchips, either.
The vaccine is still known by the code name BNT162b, but once it’s authorized, expect Pfizer to give it a new, commercial name that conveys something about what’s in it and what it promises for the world.
We thank the following people for explaining the vaccine ingredients: Jacob Becraft and Aalok Shah, Strand Therapeutics; Yizhou Dong, Ohio State University; Jason Underwood, Pacific Biosciences; Andrey Zarur, Greenlight Biosciences; Charles L. Cooney, MIT; and the communications staffs of Pfizer and Moderna Therapeutics.
All this time the mRNA was thought to be regular messenger RNA. Not the case...
How durable is this modified RNA? Where do these unnamed nucleosides go when they finally do break down? Are they carcinogenic?
Thanks MIT.
*
The only reason why I chose to get the Pfizer vaccine over Moderna is because the main ingredient of the pfizer vaccine is what is used in Mira lax which Ive taken for almost 3 yrs now without any issues(No allergy) so figured if I had to choose Id go with one that has an ingredient that Im used to
If DNA is he building plans for your body, mRNA is the kernal operating software for your body... then what if the vaccine causes a bug in the software?
Coors Lite?
What ingredient in this genetics experiment is also in Mira-lax?
The "Vaccine" is not labeled as such and is not approved by the FDA to be a vaccine.
It is a experimental therapy given given FDA Go-Ahead for use as such.
Fyi
Fat tire
Ok - fair enough
It looks like an article with an agenda - to calm down all the scary talk about these genetics experiments. But I haven’t seen many articles that talk about the modified nucleosides.
They all say vaccine on the vials.
The virus gene sequence Pfizer uses to create the spike protein mRNA can vary to account for virus mutations and improve performance.
https://news.mit.edu/2020/rna-vaccines-explained-covid-19-1211
https://www.nytimes.com/interactive/2021/health/pfizer-coronavirus-vaccine.html
https://kevinfolta.medium.com/anatomy-of-the-pfizer-covid19-mrna-vaccine-eb29beff7aa3
Polyethylene glycol.
Oh, this is so cool... and so important we embrace this cutting edge technology as a team... because it’s like... so cool and amazing... it’s science — jab me, baby, jab me!
It’s my understanding (via hearsay) the “vaccine” classification provides some type of legal protections for pharma. Do you know if that’s the case?
Yes, but in this case the the modification is an analog to the usual nucleoside in a few places in the RNA gene sequence
Of the spike protein.
An approach that gets an organism to express a gene (create a protein) that that organism doesn’t produce on its own is gene therapy or a trans genetic experiment.
These “vaccines” literally create trans genetic humans, for some period of time.
I did read the first two pdf pages of the 126 page Label.
Just curious if you know what the vial says.
Keep in mind, the product name listed can be different from the legal Label.
Just did a google image search for COVID vaccine vial.
Yeah, it does say "vaccine" on the bottles, but don't bet your life that it is accurate. They have been fined many times for mislabeling products and other violations. I think the game is that they just pay a portion of their profits back to the FDA as a fine at a latter date. That way everybody makes a lots of money. It's so wonderful to be corrupt!
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.