Posted on 02/18/2021 4:47:31 PM PST by PhxRising
Polack et al. (Dec. 31)1 report a vaccine efficacy of 94.8% against Covid-19 after two doses of the messenger RNA (mRNA) vaccine BNT162b2 (Pfizer–BioNTech). The authors also report a vaccine efficacy of 52.4% from after the first dose to before the second dose, but in their calculation, they included data that were collected during the first 2 weeks after the first dose, when immunity would have still been mounting.1 We used documents submitted to the Food and Drug Administration2 to derive the vaccine efficacy beginning from 2 weeks after the first dose to before the second dose (Table 1). Even before the second dose, BNT162b2 was highly efficacious, with a vaccine efficacy of 92.6%, a finding similar to the first-dose efficacy of 92.1% reported for the mRNA-1273 vaccine (Moderna).3
With such a highly protective first dose, the benefits derived from a scarce supply of vaccine could be maximized by deferring second doses until all priority group members are offered at least one dose. There may be uncertainty about the duration of protection with a single dose, but the administration of a second dose within 1 month after the first, as recommended, provides little added benefit in the short term, while high-risk persons who could have received a first dose with that vaccine supply are left completely unprotected. Given the current vaccine shortage, postponement of the second dose is a matter of national security that, if ignored, will certainly result in thousands of Covid-19–related hospitalizations and deaths this winter in the United States — hospitalizations and deaths that would have been prevented with a first dose of vaccine.
In order to more quickly protect people against Covid, the UK and, I believe, Europe are prioritizing giving the first dose to wider segment of the population before giving the second dose.
In fact, AstraZeneca has said the second dose of their vaccine is most effective when given 120-days after the first. Pfizer and Moderna have not done any studies of the best time to give the second dose, so they can't definitely say that giving the second dose 21-days after the first is the MOST effective protocol.
“Interesting that Pfizer, Moderna and CDC are not following the science by insisting on giving two doses of the Pfizer or Moderna Covid-19 vaccine.”
They are following the science.
They are following the science.
Thanks!
Interesting they’re claiming a >90% efficacy considering multiple reports of people contracting COVID after receiving both doses AND recipients being told they can still acquire & transmit COVID after being vaccinated.
I was shocked when I found out the issues of Merck’s shingles vaccine (that has now been pulled) as I was researching my own issue.
So much could go wrong and you just dont know it yet.
UK:
First dose: 16,423,082
Second dose: 573,724
First priority group age 65+
I saw a medical paper a month or two ago that reported on either Pfizer or Moderna trials of a full-strength #1 dose followed by either a half-strength or full-strength #2 dose at various intervals between the two doses. I think I read that they concluded the current regiment of two full strength doses 21 days apart was optimal.
I was looking for the paper last night but couldn’t find it.
So I’m supposed to be believing articles published by The New England Journal of Medicine now?
Yeah, right.
Merck.
As in the producers of Vioxx?
Merck has a history of putting out medicines with bad side effects.
I would not trust anything from them.
Why would anyone trust any entity whose main motivation is money? You know, drug makers, politicians, bureaucrats, etc.
The comments to the article from other doctors are funny. The money shot:
“...Thus, the preliminary data do not appear to support the conclusion that this vaccine offers protection against severe Covid-19 illness or alleviate the theoretical concern over vaccine-mediated disease enhancement,
given that the percentage of Covid-19–positive patients in whom severe illness developed was significantly higher in the vaccine group than in the placebo group.
Xiang Wang, Pharm.D.
Ottawa Hospital Research Institute, Ottawa, ON, Canada”
Bears Repeating: “!!! the percentage of Covid-19–positive patients in whom severe illness developed was significantly higher in the vaccine group than in the placebo group. !!!”
Too funny.
New England Journal of Muchbullcrap
What I was doing was reading an article that might make some here start to quiver in righteous, learned indignation. If you identify with that category please move on. Although any one of you could probably answer my question quickly.
Here's the story, https://rinascimentoitalia.it/wp-content/uploads/2020/10/A-DARPA-Funded-Implantable-Biochip-to-Detect-COVID-19-Could-Hit-Markets-by-2021.pdf
While reading it I wondered if a "lipid nanoparticle (LNP)-encapsulated mRNA-based vaccine" really qualified as a vaccine. You know how the scientists work their magic show distraction, look over here at the mRNA puzzle... I looked up the definition of vaccine just to make sure I was on the right track and, sure enough, Pathogen-derived preparation that provides acquired immunity to an infectious disease assured me I was.
Next question was hmmm, pathogen?
From https://www.frontiersin.org/articles/10.3389/fimmu.2019.00022/full
... These nano-sized materials can be obtained from biological sources and/or can be synthetic.Currently, there is a large variety of particles evaluated as antigen carriers, including inorganic and polymeric nanoparticles, virus-like particles (VLPs), liposomes and self-assembled protein nanoparticles (Figure 1A). The advantages of these materials reside primarily in their size (at least one dimension should be at the nanometer level), since many biological systems such as viruses and proteins are nano-sized (25). Nanoparticles can be administered via sub-cutaneous and intramuscular injections, or can be delivered through the mucosal sites (oral and intranasal), and penetrate capillaries as well as mucosal surfaces (26, 27). Recent progresses have allowed the preparation of nanoparticles with unique physicochemical properties. For instance, size, shape, solubility, surface chemistry, and hydrophilicity can be tuned and controlled, which allows the preparation of nanoparticles with tailored biological properties (28). Moreover, nanoparticles can be designed to allow the incorporation of a wide range of molecules including antigens which makes them highly interesting in vaccinology (29, 30).
The question became what about those nanoparticles? How do we know we're getting the right ones? These scientific logistics people can't seem to deliver on the right mRNA-1273 how can us lesser lights trust they know they're putting the right nano powder in the bottle?
Any reassuring words to share?
I’ll tell you, this has really put a crimp in my already low levels of trust of the medical community.
I have had a couple doctors who have been wonderful, who I trust, but that is rare.
I believe two Canadian studies are responsible for these findings.
Bears Repeating: “!!! the percentage of Covid-19–positive patients in whom severe illness developed was significantly higher in the vaccine group than in the placebo group. !!!”
Too funny.
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I know right? You can’t make this stuff up.
The other part that people seem to gloss over is that the vaccines purpose and what it is being measured by, is the reduction in the severity of symptoms not on immunity.
Like I said, you can’t make this stuff up.
NEJM is only one of the most prestigious medical journals, but go ahead and dismiss anything that the literature says supporting the vaccines.
So now we are against capitalism on this forum? Really? Every business in a noncommunist society is motivated by money and profit. Perhaps you would like to wander over to DU and live on the commune for a while.
Pharm.D. is hardly another “doctor”
https://www.solcohealthcare.com/ ...a fully owned subsidiary of Prinston Pharmaceutical, Inc. and Zhejiang Huahai Pharmaceutical, leaders in drug development and manufacturing of Active Pharmaceutical Ingredients (API) and finished dosage products. Together we strive to offer greater access to affordable medications that you can trust.
Look for Solco Healthcare on your prescription labels to see if you're walking through an UNknown minefield.
BTW. You have any idea how we can be sure not applying the right amount of nano powder to the mix is not responsible for the unfortunate results of getting vaccinated some folks experience?
I'm asking for an elderly friend
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