I think cities kill your soul. I moved from Seattle (My home for 46 years) to a hobby farm in rural KY in 2011 and it was the best move I ever made.
I used to be into bike riding (I did 19 Seattle to portland bike rides) and other stuff to “keep me busy”. Now, I get to mow about 9 acres every week with my zero turn mower, I have room to buy and package merchandise to sell on eBay and other outlets, get plenty of exercise maintaining the property, and life is MUCH slower and more appreciated. I need to get back on the bike one of these days, though.
I was stationed in Seoul back in the 90s. The city's population density is about 2X that of NYC and 4X that of Los Angeles. At one point in my tour, I was able to take a week's leave and travel to the USO "resort" on Cheju Island, which sits off the south coast of the Korean peninsula, and turned out to be one of my favorite vacation spots I've ever visited.
I did not realize how much stress and anxiety built up merely by virtue of being in a city like that, until it was gone. If my experience is like others, city dwellers simply become accustomed to the stress of living there, and assume it is part of the human experience. One does not even notice it is there, but feels immediate relief when it is gone.
I don’t know about killing your soul, but I think urban life is conducive to mental illness.