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Convalescent plasma is safe to treat COVID-19: nationwide study
NBC News via Yahoo! ^ | May 14, 2020 | Conor Ferguson and Cynthia McFadden and Didi Martinez and Rich Schapiro

Posted on 05/14/2020 6:49:02 PM PDT by ProtectOurFreedom

The most comprehensive national study to date has found that convalescent plasma appears to be safe to use on COVID-19 patients, a promising development in the race to find a treatment for the deadly virus. But the study didn't determine whether the treatment works.

A team of more than 5,000 doctors from over 2,000 hospitals and laboratories have been testing the experimental therapy, which involves transfusing the antibody-rich blood serum of recovered COVID-19 patients into people who are battling the illness.

Of the 5,000 seriously ill patients who received blood plasma transfusions for the study, fewer than 1 percent experienced serious adverse events. The mortality rate seven days after treatment was 14.9%, but the researchers noted the infusion patients were already gravely ill and the rate "does not appear excessive."

“We're encouraged that the treatment is safe,” Dr. Michael Joyner, a physiologist at the Mayo Clinic and the principal investigator of the study, told NBC News. “That was really the first hurdle for us. And showing that it's safe gives us confidence to move on and begin to try to understand the efficacy.”

The study, co-authored by researchers at institutions including Michigan State University and Johns Hopkins, hasn’t undergone peer review or publication in a scientific journal. Results were posted on MedRxiv so that other scientists and physicians could quickly review the data.

“I've never put a paper on a preprint server before in my life, and I've published almost 500 papers,” Joyner said. “We wanted to get them out there to the treating physicians and the general public as soon as we could.”

Joyner said the researchers will start receiving data on the treatment’s effectiveness in the next few weeks. He expects to have a “much clearer picture” within the next several months.

(Excerpt) Read more at news.yahoo.com ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: convalescent; covid19; plasma; therapy
It's safe, but it's not known if it works. I guess that's a small step forward.
1 posted on 05/14/2020 6:49:02 PM PDT by ProtectOurFreedom
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To: ProtectOurFreedom

Drinking water to treat Covid has been approved since it is safe. Don’t know if it works.


2 posted on 05/14/2020 6:51:06 PM PDT by nwrep
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To: ProtectOurFreedom
Link to the paper on medRxiv: Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients

Methods:
...we analyzed key safety metrics after transfusion of ABO-compatible human COVID-19 convalescent plasma in 5,000 hospitalized adults with severe or life threatening COVID-19, with 66% in the intensive care unit, as part of the US FDA Expanded Access Program for COVID-19 convalescent plasma

Results:
The incidence of all serious adverse events (SAEs) in the first four hours after transfusion was <1%, including mortality rate (0.3%). Of the 36 reported SAEs, there were 25 reported incidences of related SAEs, including mortality (n=4), transfusion-associated circulatory overload (TACO; n=7), transfusion-related acute lung injury (TRALI; n=11), and severe allergic transfusion reactions (n=3). However, only 2 (of 36) SAEs were judged as definitely related to the convalescent plasma transfusion by the treating physician. The seven-day mortality rate was 14.9%.

Conclusion:
Given the deadly nature of COVID-19 and the large population of critically-ill patients included in these analyses, the mortality rate does not appear excessive. These early indicators suggest that transfusion of convalescent plasma is safe in hospitalized patients with COVID-19.

3 posted on 05/14/2020 6:57:37 PM PDT by ProtectOurFreedom
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To: ProtectOurFreedom

“The mortality rate seven days after treatment was 14.9%, but the researchers noted the infusion patients were already gravely ill and the rate “does not appear excessive.””

I hope I never end up in one of these studies where they intentionally wait until you’re damned near dead so they can study you.


4 posted on 05/14/2020 6:59:40 PM PDT by Lurkina.n.Learnin (The Revolution Will Not Be Televised but It Will Be Livestreamed)
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To: ProtectOurFreedom

“...But the study didn’t determine whether the treatment works...”

Let’s see now...since water is not SOLD BY BIG PHARMA for big bucks...oh, wait...it is supposed to be declared dangerous and unproven like HCQ...where is Doctor Doom when we need him to save us?...protect us from safe therapies...


5 posted on 05/14/2020 6:59:53 PM PDT by EagleUSA
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To: Lurkina.n.Learnin

If the death rate after treatment after HCQ was 14.9% do you think they would bury that three paragraphs down?


6 posted on 05/14/2020 7:05:02 PM PDT by edwinland
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To: EagleUSA

Let’s see now...since water is not SOLD BY BIG PHARMA for big bucks...

Don’t give them any ideas!


7 posted on 05/14/2020 7:08:08 PM PDT by Flick Lives (The real virus is the MSM)
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To: ProtectOurFreedom

“...A team of more than 5,000 doctors from over 2,000 hospitals and laboratories have been testing the experimental therapy, which involves transfusing the antibody-rich blood serum of recovered COVID-19 patients into people who are battling the illness.

Of the 5,000 seriously ill patients who received blood plasma transfusions for the study,...”
*****************************************
Wow.... a team of “more than 5,000 doctors” tested convalescent plasma therapy on 5,000 patients. I guess they had no shortage of doctors.


8 posted on 05/14/2020 7:12:53 PM PDT by House Atreides (It is not a HOAX but it IS CERTAINLY A PRETEXT.)
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To: ProtectOurFreedom

Texags site Drs have used it and it has been successful

they have used the Genentech drug and been successful.

A Dr gives HQC early on and has been successful. If you get the symptoms anywhere near Garland Tx you might want to go to him as a Dr. He gives daily updates on COvid19.


9 posted on 05/14/2020 7:17:00 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: ProtectOurFreedom

Gin and tonic(quinine) in reasonable doses is safe.

“But the study didn’t determine whether the treatment works”

I’ll take my chances.


10 posted on 05/14/2020 7:20:58 PM PDT by dynachrome (The panic will end, the tyranny will not)
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To: edwinland

That struck me, too. Sure the test subjects were very ill, but 15% died!?

I wonder how many were going to die without the treatment. 16%? 20%? 50%?


11 posted on 05/14/2020 9:36:07 PM PDT by ProtectOurFreedom
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To: ProtectOurFreedom

“It’s safe, but it’s not known if it works.”

it’s also not scalable ...


12 posted on 05/14/2020 9:51:10 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: nwrep

Probably doesn’t have a 14.9% mortality rate?


13 posted on 05/15/2020 12:16:12 AM PDT by Delta 21 (Be strong & prosper, be weak & die! Stay true.... ~~ Donald J. Trump)
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To: Lurkina.n.Learnin

You gotta be close to on your last breath and probably whacked out of your mind on drugs before they even let you try, then they use that as the excuse you died and skewed their desired results. At least it isnt an excessive amount to them.


14 posted on 05/15/2020 12:21:18 AM PDT by Delta 21 (Be strong & prosper, be weak & die! Stay true.... ~~ Donald J. Trump)
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