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Coronavirus’s ability to mutate has been vastly underestimated, and mutations affect deadliness of strains, Chinese study finds
South China Morning Post ^ | 04/21/2020 | Stephen Chen

Posted on 04/21/2020 12:46:06 PM PDT by SeekAndFind

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1 posted on 04/21/2020 12:46:06 PM PDT by SeekAndFind
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To: SeekAndFind

But the weaker mutation did not mean a lower risk for everybody, according to Li’s study. In Zhejiang, two patients in their 30s and 50s who contracted the weaker strain became severely ill. Although both survived in the end, the elder patient needed treatment in an intensive care unit.


2 posted on 04/21/2020 12:46:32 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

This has dire implications if true.

Scientists believed that the virus’s different strains weren’t meaningfully different from each other, which is why they were optimistic that a vaccine would have long-lasting effect. We could vaccinate against the baseline virus and be confident that it would confer immunity against COVID’s many distinct mutations.

Now here comes a Chinese study challenging the conventional wisdom. If you use basic techniques to distinguish one strain from another then yes, they all look more or less alike. But if you use “ultra-deep” genome sequencing, you begin to see subtle differences with potentially momentous consequences.

Even if we believe that China’s cooking the books, it’s conceivable that the early strain that spread in Wuhan was less deadly than later mutations in other countries. Which would be ominous, as it would leave us to wonder how much more deadly the virus might get as it continues to mutate.


3 posted on 04/21/2020 12:48:21 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Sounds like something right out of Adam the Schiff’s playbook..


4 posted on 04/21/2020 12:50:22 PM PDT by CMailBag
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To: SeekAndFind

Here we go... The end is near.


5 posted on 04/21/2020 12:50:45 PM PDT by Hildy (Don't get bitter, get better.)
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To: SeekAndFind

clearly, we must remain locked-down forever!

Shelter in place!


6 posted on 04/21/2020 12:51:02 PM PDT by PGR88
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To: SeekAndFind

Interesting.

I have wondered if there are variations.

Nextstrain websit has excellent genomic analysis of cases.

The New York samples tend to differ in clade than others parts of the country.

Polymorphism are not large. How such small variations would confer greater lethality is not known, or if they do.


7 posted on 04/21/2020 12:51:06 PM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: SeekAndFind

This makes sense. I know of two groups infected separately.

One group, seven people, everyone got very ill and two died. One has been in the ICU for a long time.

Another group, family of 8, the dad got the sniffles and no one else had symptoms.


8 posted on 04/21/2020 12:51:22 PM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem)
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To: SeekAndFind

Always concerned me that it could mutate into Dos Equis or some other Mexican beer.


9 posted on 04/21/2020 12:52:33 PM PDT by Hillarys Gate Cult
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To: SeekAndFind

And coming from Chinese Communists we believe anything they say right?


10 posted on 04/21/2020 12:52:48 PM PDT by jmaroneps37 (Conservatism is truth. Liberalism is lies.)
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Comment #11 Removed by Moderator

To: ifinnegan

Here is another concern regarding the implications of this study IF TRUE:

Does the Chinese study help explain why many tests are so inaccurate?

Is it possible that some strains of the virus have diverged from each other so much that a diagnostic test targeting one would fail to detect another?

If you’re infected by one strain of the virus, are the antibodies left in your system effective against other strains? That’s really a variation of the vaccine question.


12 posted on 04/21/2020 12:53:16 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

The Spanish flu mutated into the final, deadly edition.


13 posted on 04/21/2020 12:53:50 PM PDT by JonPreston
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To: SeekAndFind

Mutation also frustrates making a vaccine. The bug is a moving target. That’s why they change flu shots each year.


14 posted on 04/21/2020 12:53:59 PM PDT by shalom aleichem (Durham and Barr! *hit or get off the pot!)
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To: jmaroneps37

RE: And coming from Chinese Communists we believe anything they say right?

It’s from a Chinese SCIENTIST. Not all Chinese are political. The science should be judged on its own merits.

If he publishes the study in a reputable journal and the study can be replicated then we can’t simply use the Chicom label as an excuse to disregard the results.


15 posted on 04/21/2020 12:55:08 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

May as well pass out the cyanide pills.


16 posted on 04/21/2020 12:56:47 PM PDT by brianr10
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To: shalom aleichem

One solution would be this -— Find a strain of the virus that produces few symptoms but triggers enough antibodies to fend off more deadly strains of the disease and you have an effective partial vaccine.This would be worth it if you knew that the version of the disease you were infected with had far more upside than downside risk.

Seems like the first step in figuring out if the Chinese study is correct would be to sequence different strains around the country in a basic way and see which ones have higher concentrations of the New York/Europe strain and which don’t.

Is the strain more common in areas where deaths and hospitalizations are higher? If so, what do we do about isolating those regions — and controlling travel from Europe, since we won’t want anyone importing that strain once we’ve contained it here?

Here’s another irony — It’s conceivable that we’d have more to fear from travel from NATO countries than we do from China.


17 posted on 04/21/2020 12:57:38 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

Natural selection causes viruses to mutate towards being less deadly. A virus that kills it’s host is a Darwinian dead-ender.


18 posted on 04/21/2020 12:58:02 PM PDT by Buckeye McFrog (Patrick Henry would have been an anti-vaxxer)
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To: SeekAndFind

Commie’s suck.


19 posted on 04/21/2020 12:58:30 PM PDT by JPJones (More Tariffs, less income tax.)
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To: shalom aleichem

This is not the first coronavirus. They’ve always been around. They cause colds. We’ve never had a vaccine for the common cold.


20 posted on 04/21/2020 12:58:46 PM PDT by Buckeye McFrog (Patrick Henry would have been an anti-vaxxer)
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