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To understand the challenges of the treatment of Coronavirus with Chloroquine, we advise you to read the interview with Professor Raoult in the Parisian of March 22, 2020
Le Parisien, Google Translate French => English ^ | March 22, 2020 at 4:20 p.m., modified March 23, 2020 at 6:14 a.m. | Frédéric Mouchon

Posted on 03/29/2020 11:38:34 AM PDT by FreedomPoster

PRESENTATION OF PROFESSOR RAOULT Joined Sunday, this infectious disease specialist says he is convinced he has found a cure for the coronavirus. Professor Raoult deems it "immoral" to wait to administer it and says that he does not "care" that a clinical trial has been launched.

Didier Raoult is convinced of this: he has found "the" most effective remedy for treating patients with Covid-19.

Director of the Mediterranean Infection Marseille University Hospital Institute (Bouches-du-Rhône), this infectiologist, specialist in emerging tropical infectious diseases, says that chloroquine, an antimalarial used for decades and well known to travelers as Nivaquine, has dramatic effects on the ongoing epidemic.

Six days after giving it to patients with Covid-19, he said, only 25% of them were still infected with the virus, while 90% of those who had not received it were still positive.

If some of his colleagues do not take him seriously, questioning his methods and the results of his therapeutic trials, the Minister of Health, Olivier Véran, announced Saturday March 21 that this treatment would be tested "on a larger scale "

"I asked that Professor Raoult's study be reproduced [...] in other hospitals, by other independent teams, said the minister. I am that of extremely close. "

The government remains cautious, however, because Pr Raoult's results were obtained on 24 patients only, without placebo. "No country in the world has ever granted a treatment authorization on the basis of a study like this," underlines Olivier Véran.

(Excerpt) Read more at translate.googleusercontent.com ...


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To: wastoute

RE: I read it, he didn’t define his selection criteria.

You said that you suspect that he probably selected mostly asymptomatic patients in order to later to “advertise”that his protocol worked.

I wonder whether we are reading the same paper.

From the paper whose PDF link I sent you.... COPY AND PASTE from the section: Clinical classification and clinical follow-up

[START OF THE EXCERPT]

Upon admission, patients were grouped into two categories:

i) those with an upper respiratory
tract infection (URTI) presenting with rhinitis and/or pharyngitis, and/or isolated low-grade
fever and myalgia, and

ii) those with lower respiratory tract infections (LRTI) presenting with symptoms of pneumonia or bronchitis.

The time between the onset of symptoms and
admission, and the time between the onset of symptoms and treatment was documented.

Risk factors for severe COVID-19, including older age, cancer, cardiovascular disease, hypertension, and diabetes (4), as well as chronic obstructive pulmonary disease, obesity and any immunosuppressive treatments were documented.

The national early warning score (NEWS) for COVID-19 patients, was collected upon ward admission and during follow up. The NEWS score was calculated based on the following parameters:

Age, respiratory rate, oxygen saturation, temperature, systolic blood pressure, pulse rate and level of consciousness (19). We defined three risk categories for clinical deterioration: low score (NEWS 0-4), medium score (NEWS 5-6), and high score (NEWS) for COVID patients.

The need for oxygen therapy, transfer to the intensive care unit (ICU), death, and length of stay in the ID ward were documented.

Chest computed tomography

Patients systematically underwent an unenhanced chest low-dose computed tomography (LDCT) upon admission or soon after, using a single CT machine (Revolution EVO - GE Healthcare, WI, USA). All images were analysed by experienced chest radiologists, then
classified as compatible or not compatible with pneumonia.

Images were considered to be compatible in the presence of peripheral multifocal ground-glass opacities with or without reticulations, or in the presence of alveolar consolidation or crazy paving pattern.

[END OF THE EXCERPT]

What ever he did, Dr. Raoult did not rig his study to only select asymptomatic Covid-19 positive patients. as you alleged.


41 posted on 03/29/2020 4:45:43 PM PDT by SeekAndFind (look at Michigan, it will)
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To: wastoute

RE: I want to actually save lives.

As do we all. But your skepticism isn’t healthy IMHO.


42 posted on 03/29/2020 4:47:04 PM PDT by SeekAndFind (look at Michigan, it will)
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To: wastoute

Here is what one of the primary Chicken Littles wrote a few days ago. They constantly predict catastrophe. Then a day will come when they blame Trump for a horrific economy that was shut down for too long.

Here is just one fear monger prediction from a chicken little

( below )

>>>>It crosses my mind that when we have some 2,000 deaths in one day next weekend (this weekend) people may lose their appetite to return to work.<<<

posted on 3/23/2020, 11:35:51 AM
by >> wastoute <<

26 posted on 3/29/2020, 4:42:15 PM by Calif Conservative (A)


43 posted on 03/29/2020 4:47:19 PM PDT by Calif Conservative (A)
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To: wastoute

So you changed your screen name. It’s still trash.>>>>>>>>>>>>>>>>>>>>>>>>>>

You will have to be more specific.


44 posted on 03/29/2020 4:47:52 PM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: jjotto

Effective treatment of such a high-risk population is very significant.>>>>

I concluded the same. But the therapy has to be administered early, before the lungs fill with mucus.


45 posted on 03/29/2020 4:49:27 PM PDT by Candor7 ((Obama Fascism)http://www.americanthinker.com/articles/2009/05/barack_obam_the_quintessentia_1.html))
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To: wastoute; freeandfreezing

RE: “Promising results” is not the same as saving lives.

Sure, but “Promising results” also means that IT ACTUALLY WORKED for small number of people.

It also means we don’t abandon the protocol and OUGHT TO TRY IT.

If Kobe Bryant ( who wasn’t that good in his first few years in the NBA ) showed “promise”, what do you do?

Do you simply leave him benched, or do you try him out?


46 posted on 03/29/2020 4:52:05 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

I just looked at my gmail. I don’t see anything from you. I clicked a link to the article in the thread for Dr Raoul. “Cleared the virus” is not an endpoint I care about. Mortality. Decreased mortality. I don’t care about drugs that give you three days less of runny nose. Decreased mortality.


47 posted on 03/29/2020 4:52:31 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: SeekAndFind

You don’t understand. My skepticism kept me from harming patients. 40 years and not one lawsuit. I’d say I didn’t do too badly.


48 posted on 03/29/2020 4:53:39 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: SeekAndFind

So it saved lives? Decreased mortality? What study is that? I’d love to see it.


49 posted on 03/29/2020 4:55:19 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: Calif Conservative

That was a week ago. I have already posted I was off a day or two.


50 posted on 03/29/2020 4:56:23 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: wastoute
As I continue to point out the paper that would end the controversy doesn’t seem to be forthcoming.

So I know what to look for, could you provide a 4 sentence list of what the thresholds for such a paper would be? Things like sample size, p value thresholds, measure of success, etc.

51 posted on 03/29/2020 4:57:15 PM PDT by freeandfreezing
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To: wastoute

RE: You don’t understand. My skepticism kept me from harming patients. 40 years and not one lawsuit. I’d say I didn’t do too badly.

You sir, are talking about NORMAL TIMES. We are not living in normal times ( an understatement ).


52 posted on 03/29/2020 4:58:03 PM PDT by SeekAndFind (look at Michigan, it will)
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To: wastoute

RE: I just looked at my gmail. I don’t see anything from you.

I sent you a link to the PDF study. You never gave me your email,why should you expect an email via gmail?


53 posted on 03/29/2020 4:59:05 PM PDT by SeekAndFind (look at Michigan, it will)
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To: SeekAndFind

I typed bmail. I got AutoKKKorected.


54 posted on 03/29/2020 4:59:37 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: wastoute

RE:So it saved lives? Decreased mortality? What study is that? I’d love to see it.

Again, here is the paper:

https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf

Please read the paper and tell us which part of the study you find questionable and how you would change the study to make it acceptable to you (given the exceptional situation we find ourselves in ).


55 posted on 03/29/2020 5:01:41 PM PDT by SeekAndFind (look at Michigan, it will)
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To: wastoute

Ah so you’re moving the goal posts. Excellent

You were “off” by a day or two

aka wrong


56 posted on 03/29/2020 5:03:11 PM PDT by Calif Conservative (A)
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To: wastoute

By the way, I posted to you Dr. Raoult’s selection criteria in his study, I’m still waiting for you to tell me whether you still believe he only chose asymptomatic patients or not, or can we dispense with that canard?


57 posted on 03/29/2020 5:03:35 PM PDT by SeekAndFind (look at Michigan, it will)
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To: Calif Conservative

My est. was based on a doubling time of 2 days. Better data shows the doubling time is about 2.6. That is the source of error in my estimate.


58 posted on 03/29/2020 5:06:44 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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To: Candor7

Quick! Hide this and require two year double-blind tests ( or at least till after the 2020 elections) so maybe “we” can take President Trump out with a closed down economy, high unemployment and “we” Dems promising the world.

Tell me I’m wrong.


59 posted on 03/29/2020 5:09:01 PM PDT by Tunehead54 (Nothing funny here ;-)
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To: SeekAndFind

Thank you, thank you, thank you. Finally an “actual paper”. The link I was was an interview with the guy and based on that I didn’t see it. Finally, an article that takes me longer than a few seconds to throw in the trash. I promise I will read it carefully in the morning. My wife is tapping her foot right now. I did glance at the conclusions. I agree there is potential to show viral clearing to decrease progression of the disease to a more sever form. Let me spend some time reading this carefully. As I have pointed out before, to have an effect on a “blue patient” a drug has to have a stunning effect. In my experience shows promise can still be a coin toss or worse in the ICU. Drugs like gentamicin which are highly effective frequently fail in the ICU.

As I have said all along, there were people taking these drugs prior. How did they do?


60 posted on 03/29/2020 5:10:53 PM PDT by wastoute (Government cannot redistribute wealth. Government can only redistribute poverty.)
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