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Full-genome evolutionary analysis . . . (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event
https://www.biorxiv.org/content/10.1101/2020.01.26.920249v1 ^

Posted on 01/28/2020 5:41:33 AM PST by BusterDog

I think this Dr's comments on this study are very interesting, he addresses the bioweapon conspiracy talk:

(Excerpt) Read more at biorxiv.org ...


TOPICS: News/Current Events
KEYWORDS: coronavirus
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2. Again, no outright conspiracy theories please. Here is another explanation: The new #coronavirus is an RNA virus—that is, viruses that have RNA as their genetic material rather than DNA—which have a “high mutation rate,” which allows it to “change properties very quickly.”— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



3. The RNA sequences of the #coronavirus isolated from 6 patients from the same household are different from each other (Lancet), sign of the virus evolving. This may not be so good to the ear; it suggests the difficulty of containing this virus”. (from https://t.co/8IPxJf5I3P)— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



4. DEEPER DIVE into #coronavirus RNA genome 🧬, here goes... “it came from bats 🦇” is often heard, but it’s trickier. The 🦠 has similarities to bat coronavirus, but this new paper REJECTS there was recent recombination. There is something discordant too:https://t.co/uABEwa0f9s— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



5. (Continued from above)... “A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2)” —> it’s a sequence entirely new to any known #coronavirus. What does this mean? We don’t know yet.— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



6. “Notably, the new coronavirus provides a new lineage for almost half of its genome, with no close genetic relationships to other viruses within the subgenus of sarbecovirus.” —> basically it’s saying it’s completely brand new to #coronavirus subgenus.— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



7. Very strange: So what is in this new mystery middle segment that has no #coronavirus history? The study authors continue: “This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30,31]”.🤔— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



8. Continuing: “Our study rejects the hypothesis of emergence as a result of a recent recombination event.”—> I.e. the authors also conclude that the new #coronavirus did not originate from random recent admixture between different coronaviruses. Other possibilities of course.— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



9. BOTTOMLINE: 1) Seafood market not the source. 2) This RNA #coronavirus mutates really fast. 3) 🧬 has unusual middle segment never seen before in any coronavirus. 4) Not from recent mixing. 5) That mystery middle segment encodes protein responsible for entry into host cells.— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020



10. TO BE CLEAR: I am absolutely not saying it’s bioengineering, nor am I supporting any conspiracy theories with no evidence. I’m simply saying scientists need to do more research + get more data. And finding the origin of the virus is an important research priority. Goodnight😴 pic.twitter.com/N4Yp2H8Tst— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020


1 posted on 01/28/2020 5:41:33 AM PST by BusterDog
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To: BusterDog
Well , it could be a head fake but “Chinese” officials claim the market was the source:

https://www.google.com/amp/s/www.dailymail.co.uk/health/article-7935167/amp/Deadly-coronavirus-outbreak-DID-start-animal-market-Wuhan-tests-confirm.html

2 posted on 01/28/2020 5:46:06 AM PST by 11th_VA
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To: 11th_VA

Yeah, I’m not supporting or apologizing for the animal market explanation, but as a non-biologist/non-expert, the problem of the middle code segment could be explained by the fact that it existed for a long time in animal populations before jumping to humans, at this market.

It sounds like a cover, but that doesn’t mean that it is.


3 posted on 01/28/2020 5:50:28 AM PST by z3n
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To: 11th_VA
10. TO BE CLEAR: I am absolutely not saying it’s bioengineering, nor am I supporting any conspiracy theories with no evidence. I’m simply saying scientists need to do more research + get more data. And finding the origin of the virus is an important research priority. Goodnight😴 pic.twitter.com/N4Yp2H8Tst— Dr. Eric Feigl-Ding (@DrEricDing) January 28, 2020


4 posted on 01/28/2020 5:51:03 AM PST by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: BusterDog

Well, as ANY half-decent conspiracy theorist (aka “paranoid schizotypal personality disordered individual”) would say, sub rosa,”that’s what they WANT you to believe.”

A reminder: FORSYTHIA is the cure THEY don’t want you to know about! Read the Georgia Guidestones! Bill Gates funded a virology lab in Wuhan!

Ahem...


5 posted on 01/28/2020 5:54:00 AM PST by normbal (normbal. somewhere in socialist occupied America)
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To: 11th_VA

"Well done, Mr. Gates, Mr. Soros, and Canada.
Your virus .... will kill."

6 posted on 01/28/2020 5:56:29 AM PST by Diogenesis ( WWG1WGA)
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To: z3n
And the Chinese Commies Dictatorship have sealed off there home in Beijing for fun and kicks.
Has WHO even been allowed in yet by the Chinese Commies ?.
I smell CCP planted nonsense .
7 posted on 01/28/2020 5:57:06 AM PST by ncalburt (Gop DC Globalist)
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To: neverdem; ProtectOurFreedom; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ...
Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

So far the false positive rate is 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

If a quarantine saves just one child's life, it's worth it.

8 posted on 01/28/2020 6:06:26 AM PST by null and void (The government wants to disarm us after 243 yrs 'cuz they plan to do things we would shoot them for!)
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To: BusterDog
Here's the abstract of paper on the virus (posted Jan 26): Transmission dynamics of 2019 novel coronavirus (2019-nCoV)

The condensed summary of the abstract is: "Interpretation: The 2019-nCoV may have a higher pandemic risk than SARS broken out in 2003. The implemented public-health efforts have significantly decreased the pandemic risk of 2019-nCoV. However, more rigorous control and prevention strategies and measures to contain its further spread."

The author list is included in the abstract which is interesting.

9 posted on 01/28/2020 6:07:24 AM PST by voicereason (The RNC is like the "one-night stand" you wish you could forget.)
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To: BusterDog

““This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30,31]”

And so again, I ask..when is a scientist going to reveal how this compares to the China Bat/Sars virus that was built and replicated in a mouse in 2015 at Chapel Hill


10 posted on 01/28/2020 6:08:53 AM PST by RummyChick
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To: BusterDog

What was #1 in this list?


11 posted on 01/28/2020 7:03:22 AM PST by agatheringstorm
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To: BusterDog
“A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2)” —> it’s a sequence entirely new to any known #coronavirus.”

“This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30,31]”

http://www.freerepublic.com/focus/f-news/3810535/posts Post - 30.

“Coronaviridae are enveloped viruses (they ‘bud’ out of cells when they replicate, taking part of the cell membrane with them). Enveloped viruses can be ‘pseudo-typed’ (replicated in genetically engineered cell lines that express specific envelope proteins that change the receptors/targets that the virus will bind to). In this manner, you can potentially change how a virus spreads, and even what species it can infect.”

Not ‘conspiracy’. Valid science. In this day and age, all things possible need to be considered.

12 posted on 01/28/2020 7:07:23 AM PST by neverevergiveup
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To: null and void

“If a quarantine saves just one child’s life, it’s worth it.”

Is this sarcasm?


13 posted on 01/28/2020 7:32:11 AM PST by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: ifinnegan

Nope. It’s a deliberate needling of progressives by hijacking one of their pet phrases they use to push their agendas.


14 posted on 01/28/2020 7:44:48 AM PST by null and void (The government wants to disarm us after 243 yrs 'cuz they plan to do things we would shoot them for!)
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To: neverevergiveup; 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...
Infectious Disease Ping - Wuhan (Airborne viral pneumonia)- UPDATE with Obsevations

neverevergiveup : "Not ‘conspiracy’. Valid science.
In this day and age, all things possible need to be considered."

From the original OP :

" Again, no outright conspiracy theories please.
Here is another explanation:
The new #coronavirus is an RNA virus—that is, viruses that have RNA as their genetic material
rather than DNA—which have a “high mutation rate,”
which allows it to “change properties very quickly.”— Dr. Eric Feigl-Ding

The RNA sequences of the #coronavirus isolated from 6 patients from the same household are different from each other (Lancet), sign of the virus evolving.
This may not be so good to the ear; it suggests the difficulty of containing this virus”.(Emphasis Mine)

“A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2)” —> it’s a sequence entirely new to any known #coronavirus.

“Notably, the new coronavirus provides a new lineage for almost half of its genome,
with no close genetic relationships to other viruses within the subgenus of sarbecovirus.” —> basically it’s saying it’s completely brand new to #coronavirus subgenus."

These are selected excerpts from the original posting.
Please review the original submitted posting for a more fully understanding
of the complexity of this airborne pneumonia virus and attempts to control it.

HT to FReeper Null and void for his yeoman efforts to keep us informed.

15 posted on 01/28/2020 8:00:45 AM PST by Tilted Irish Kilt
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To: Tilted Irish Kilt
Yes, of course, they stirred it up in the lab.

One would suppose that we're free to speculate about who would have access to the antidote, if there is one.

16 posted on 01/28/2020 8:04:18 AM PST by OKSooner (Free Beer Tomorrow)
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To: Tilted Irish Kilt
Find a molecular evolutionist or someone who knows both gene sequencing and mutations. Cause I *really* doubt that spontaneous mutations give rise to entire de novo segments of genome.

Something like sharing of genetic material among different strains, yes; but as I understand, the spike on the outer coat, which allows this 2019-nCoV to bind to epithelial cells deep in the lungs like SARS, is not found on other Coronaviruses.

The possible explanations are

a) transfer of genetic material between an existing coronavirus and a SARS-like analogue, in a species known to harbor both viruses, and which is in reasonable proximity to humans in Wuhan (or, someone who then traveled to Wuhan after french-kissing a snake or eating bat soup or making love to a pig or someting)

b) bioengineering

The absolutely spastic top-down response of the Chinese overlords (including Winnie The Flu) suggests far more knowledge of the virus's potential than had publicly been available at the time the quarantines were put in place.

Given the additional, political ramifications of such draconian restrictions on travel during Chinese New Year, such would be more consistent with knowledge of a bioweapon, after the local bureaucratic denial was overcome, and somebody in a position to know was "volunteered" to tell top Party officials behind the scenes.

Your mileage may vary; not valid in Alaska, Hawaii, or Puerto Rico; must be 18 or older to play; close cover before striking; other disclaimers apply.

17 posted on 01/28/2020 8:11:46 AM PST by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: janetjanet998

ping


18 posted on 01/28/2020 8:21:41 AM PST by BenLurkin (The above is not a statement of fact. It is either opinion or satire. Or both.)
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To: null and void

“Nope. It’s a deliberate needling of progressives by hijacking one of their pet phrases they use to push their agendas.”

In a way that’s kind of what I meant.


19 posted on 01/28/2020 8:31:20 AM PST by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: grey_whiskers
grey_whiskers :"Given the additional, political ramifications of such draconian restrictions
on travel during Chinese New Year, such would be more consistent with knowledge of a bioweapon.."

Given the information in the original posting,
I agree whole heartedly with you.
None the less, the original post is a scientific data study without political suppositions
and is based on data only.
The current Chinese response is incongruent with their previous behavior and response.

20 posted on 01/28/2020 8:39:48 AM PST by Tilted Irish Kilt
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