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A Mysterious Infection, Spanning The Globe In A Climate Of Secrecy
NYT ^ | 4-7-2019 | Matt Richtel and Andrew Jacobs

Posted on 04/07/2019 11:04:03 AM PDT by blam

Last May, an elderly man was admitted to the Brooklyn branch of Mount Sinai Hospital for abdominal surgery. A blood test revealed that he was infected with a newly discovered germ as deadly as it was mysterious. Doctors swiftly isolated him in the intensive care unit.

The germ, a fungus called Candida auris, preys on people with weakened immune systems, and it is quietly spreading across the globe. Over the last five years, it has hit a neonatal unit in Venezuela, swept through a hospital in Spain, forced a prestigious British medical center to shut down its intensive care unit, and taken root in India, Pakistan and South Africa.

Recently C. auris reached New York, New Jersey and Illinois, leading the federal Centers for Disease Control and Prevention to add it to a list of germs deemed “urgent threats.”

The man at Mount Sinai died after 90 days in the hospital, but C. auris did not. Tests showed it was everywhere in his room, so invasive that the hospital needed special cleaning equipment and had to rip out some of the ceiling and floor tiles to eradicate it.

“Everything was positive — the walls, the bed, the doors, the curtains, the phones, the sink, the whiteboard, the poles, the pump,” said Dr. Scott Lorin, the hospital’s president. “The mattress, the bed rails, the canister holes, the window shades, the ceiling, everything in the room was positive.”

C. auris is so tenacious, in part, because it is impervious to major antifungal medications, making it a new example of one of the world’s most intractable health threats: the rise of drug-resistant infections.

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(Excerpt) Read more at nytimes.com ...


TOPICS: News/Current Events
KEYWORDS: alreadyposted; candidaauris; disease; fungus; infection; threat; tonyorlandoanddawn
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To: blam
Good Wikipedia summary...
Candida auris is a species of fungus first described in 2009, which grows as yeast. It is one of the few species of the genus Candida which cause candidiasis in humans. Often, Candidiasis is acquired in hospitals by patients with weakened immune systems. C. auris can cause invasive candidiasis in which the bloodstream (fungemia), the central nervous system, and internal organs are infected. It has recently attracted increased attention because of its multiple drug resistance. Treatment is also complicated because it is easily misidentified as other Candida species. C. auris was first described after it was isolated from the ear canal of a 70-year-old Japanese woman at the Tokyo Metropolitan Geriatric Hospital in Japan in 2009. The first cases of disease-causing C. auris were reported from South Korea in 2011, spread across Asia and Europe, and first appeared in the U.S. in 2013.

DNA analysis of four distinct but drug-resistant strains of Candida auris indicate an evolutionary divergence taking place at least 4,000 years ago, with a common leap among the four varieties into drug-resistance possibly linked to widespread azole-type antifungal use in agriculture.


21 posted on 04/07/2019 11:39:03 AM PDT by ProtectOurFreedom
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To: blam

Yes. It always is.


22 posted on 04/07/2019 11:39:44 AM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: blam

There’s a fungus amungus. And, cue the Tony Orlando and Dawn. ;^)

http://www.freerepublic.com/focus/news/3740134/posts

http://www.freerepublic.com/tag/candidaauris/index


23 posted on 04/07/2019 11:42:05 AM PDT by SunkenCiv (Imagine an imaginary menagerie manager imagining managing an imaginary menagerie.)
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To: blam
Dozens Have Fallen Ill During A Five-State E. Coli Outbreak, And Nobody Knows Where It’s Coming From

Spells MOON.

24 posted on 04/07/2019 11:42:11 AM PDT by blam
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To: blam

First you start the rumor.
Then you ‘assign’ certain deaths to it.
Then you widen the net.
Once the net widened and panic sets in, ‘modern medicine’ will come up with an ‘experimental drug’ that know one can have until ????
Make drug available at humungous cost in US and pennies in Mexico.

Almost like saying EVERYONE that ate beans in the Civil War died.


25 posted on 04/07/2019 11:44:03 AM PDT by xrmusn (6/98"Getting rich as a Politician means doing something illegal''(trunc) HS Truman)
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To: xrmusn

There is fungus...among us.


26 posted on 04/07/2019 11:50:37 AM PDT by Amadeo
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To: blam

Ah yes. Another Disease of the Month report. Did anyone notice that it occurs in immunodeficient individuals? What a surprise! /sarc


27 posted on 04/07/2019 11:53:54 AM PDT by Scaramouch
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To: Bob434

I guess UV light used in water filtration will kill everything in the water.


28 posted on 04/07/2019 11:54:05 AM PDT by crz
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To: Bulwyf

Don’t forget the BBQ and cold beer.


29 posted on 04/07/2019 11:55:02 AM PDT by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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To: Leaning Right; null and void

Celebrate Going Global!!

I’m glass the SAPP’s noted it’s already been posted. Let’s keep this stuff out of the public eye! Hooray!


30 posted on 04/07/2019 11:59:23 AM PDT by SaveFerris (Luke 17:28 ... as it was in the days of Lot; they did eat, they drank, they bought, they sold ......)
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To: Vermont Lt

I got Thrush from my inhaler.

The doc wanted to put me on meds. I went home and used vinegar and got rid of it. Told the doc the next week I saw him and he said he will recommend that to everyone on those steroid inhalers.

GD rotten medications these days..its either take them or suffer from lack of breath.


31 posted on 04/07/2019 12:01:21 PM PDT by crz
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To: Bob434

I’ve run across UV light in hand-dryers in the bathroom.

Pretty cool. I suppose.

It was a blade hand-dryer (I think maybe it’s called that).

Place for your hands with 2 blasts of air (and UV light) in opposite directions.


32 posted on 04/07/2019 12:02:47 PM PDT by SaveFerris (Luke 17:28 ... as it was in the days of Lot; they did eat, they drank, they bought, they sold ......)
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To: zaxtres
Richard Preston's 1994 book The Hot Zone does a tremendous job explaining how hard it is to find Patient Zero and where he or she contracted the first case. It is an amazing bit of sleuthing that went into finding the source of the Marburg and Ebola viruses.
33 posted on 04/07/2019 12:14:24 PM PDT by ProtectOurFreedom
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To: crz

My guess is you are not toking on home-grown treated with pesticides and anti-fungal chemicals! Ha ha.

I had lesions in my throat. Never smoked a cigarette. My last “toke” was 1984. The only thing the doc could figure was that my blood sugar was too high and it was “splashing” out of my stomach. My A1c was an 8. A little high, but not crazy high.

10 days of anitibiotics and I was good as new.


34 posted on 04/07/2019 12:14:38 PM PDT by Vermont Lt (If we get Medicare for all, will we have to show IDs for service? Why?)
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To: mass55th

C. auris was first described after it was isolated from the ear canal of a 70-year-old Japanese woman at the Tokyo Metropolitan Geriatric Hospital in Japan.[1] It was isolated based on its ability to grow in the presence of the fungicide micafungin, an echinocandin class fungicide.[1] Phenotypic, chemotaxonomic and phylogenetic analyses established C. auris as a new strain of the genus Candida.[1][17]

The first three cases of disease-causing C. auris were reported from South Korea in 2011.[18] Two isolates had been obtained during a 2009 study and a third was discovered in a stored sample from 1996.[18] All three cases had persistent fungemia, i.e. bloodstream infection, and two of the patients subsequently died due to complications.[18] Notably, the isolates initially were misidentified as Candida haemulonii and Rhodotorula glutinis using standard methods, until sequence analysis correctly identified them as C. auris.[18] These first cases emphasize the importance of accurate species identification and timely application of the correct antifungal for the effective treatment of candidiasis with C. auris.[18]

During 2009–2011, 12 C. auris isolates were obtained from patients at two hospitals in Delhi, India.[19] The same genotype was found in distinct settings: intensive care, surgical, medical, oncologic, neonatal, and pediatric wards, which were mutually exclusive with respect to health care personnel.[19] Most had persistent candidemia and a high mortality rate was observed.[19] All isolates were of the same clonal strain, however, and were only identified positively by DNA sequence analysis.[19] As previously, the strain was misidentified with established diagnostic laboratory tests.[19] The Indian researchers wrote in 2013 that C. auris was much more prevalent than published reports indicate since most diagnostic laboratories do not use sequence-based methods for strain identification.[19]

The fungus spread to other continents and eventually, a multi-drug-resistant strain was discovered in Southeast Asian countries in early 2016.[20]

The first report of a C. auris outbreak in Europe was an October 2016 in Royal Brompton Hospital, a London cardio-thoracic hospital.[15] In April 2017, CDC director Anne Schuchat named it a “catastrophic threat”.[21] As of May 2017 the CDC had reported 77 cases in the United States on its website. Of these, 69 were from samples collected in New York and New Jersey.[22]

https://en.wikipedia.org/wiki/Candida_auris#History


35 posted on 04/07/2019 12:20:42 PM PDT by BenLurkin (The above is not a statement of fact. It is either satire or opinion. Or both.)
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To: Bob434
Theoretically it would work on any organism that has DNA/RNA.

However, it is a line-of-sight method whereas fungal spores are often air-borne and may become completely hidden.

Well, crap.

36 posted on 04/07/2019 12:21:42 PM PDT by Aevery_Freeman (The Elite: Too stupid to know when to quit stealing!)
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To: Vermont Lt

Nope. Never used the crap. Had enough lung problems through my life without doing that.

Antibiotics dont work for fungal infections-at least that was what I was told.


37 posted on 04/07/2019 12:23:57 PM PDT by crz
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To: BenLurkin

Thanks for that very interesting info, and the link.


38 posted on 04/07/2019 12:32:09 PM PDT by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne)
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To: mass55th

The CDC has done genetic sequencing on this fungus. There are several independent strains genetically different enough to indicate that there are several sources. The US strain seems to be from either India/Pakistan or Venezuela. Search for C. auris on the CDC site for more info.


39 posted on 04/07/2019 12:58:37 PM PDT by outofsalt (If history teaches us anything, it's that history rarely teaches us anything.)
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To: outofsalt

Thanks.


40 posted on 04/07/2019 1:01:15 PM PDT by mass55th ("Courage is being scared to death, but saddling up anyway." ~~ John Wayne)
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