I wouldn’t want to leave my guns in a hotel room, while I ‘enjoyed a night in Vegas’.
I don’t like to leave them unattended either. If it were me, that’s when I would make sure it was after the maids were gone for the day, and I’d have the do not disturb sign up, and my things locked away as well as the room permitted and my locked container bags permitted. As a rule I don’t like to even leave the hotel room unoccupied. But I would much rather do that than to leave them locked in a car overnight down in a garage or parking lot.
My point was that there ARE people who would do that, and it would not be unusual to see them carting their cases up to the room at the end of a day.
By law in most states, it is legal for you to have a gun in your place of domicile whether that is your home, hotel, or campsite. Its just the getting around between home and hotel that creates all the carry issues.