Which in turn depends on the accuracy of various physical models of the universe. We still have recently encountered surprises, such as so called dark matter.
But a reasonable projection is going to have the stars all dying out. I felt there was something “existentially” wrong when I read, as a child, science books that foretold the stars burning out in billions of years. From my point of view, they might as well be scheduled to burn out tomorrow, and the lack of permanence distressed me. Only much, much, much later did I realize that was God beginning to knock on the door of my mind.
Agreed - every scientific prediction comes with an asterix after it. Nevertheless, the 2nd Law of Thermodynamics seems pretty solid, especially over the long term, suggesting that one way or another the universe will eventually go out of business. What will happen when and if human knowledge advances to the point of being able to monkey with the processes described in the Timeline of the Far Future, well, let's just say that it will be...interesting.