Agreed - every scientific prediction comes with an asterix after it. Nevertheless, the 2nd Law of Thermodynamics seems pretty solid, especially over the long term, suggesting that one way or another the universe will eventually go out of business. What will happen when and if human knowledge advances to the point of being able to monkey with the processes described in the Timeline of the Far Future, well, let's just say that it will be...interesting.
Any lever into the physical world would have been provided by the good Lord. We can’t batter our way into it any further than this.
To me the biggest question about the world is no longer What. It is Whom.
And the bible had its own terms for what we geeks call the 2nd Law of Thermodynamics. “Slavery to the law of death and decay.” People already knew this was going on. It didn’t take modern science to fill them in. Modern science simply managed to wrap some numbers around it.