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Scorpion venom neutralized - A drug used in Mexico proves effective in Arizona test
Science News ^ | May 13th, 2009 | Nathan Seppa

Posted on 05/15/2009 1:26:12 AM PDT by neverdem

The Arizona bark scorpion may be small, but its sting delivers a neurotoxin that can kill or render critically ill a young child. A study in the May 14 New England Journal of Medicine finds that an antivenom drug commonly used in Mexico for such stings neutralizes the toxin, eliminates symptoms and reduces the need for sedation in children who have been stung.

More than 200 children in Arizona and a handful in New Mexico become critically ill from Arizona bark scorpion stings each year, but there is no U.S.–approved remedy for the stings. Children are rushed to intensive care units and sedated to prevent wild thrashing and choking, says pediatrician Leslie Boyer of the University of Arizona in Tucson. The victims are closely monitored until the neurotoxin’s effects fade, which takes 16 hours on average but can take several days. Some children require a mechanical ventilator to breathe.

Adults typically face painful but much milder symptoms from the sting of this scorpion, Centruroides sculpturatus.

During 2004 and 2005, Boyer and her colleagues randomly assigned 15 children showing up at Tucson hospitals with scorpion poisoning to receive either the Mexican antivenom and sedation as needed or a placebo infusion along with sedation. Both groups also received other care, such as breathing assistance if necessary. Doctors treating the patients didn’t know who was given antivenom and who wasn’t.

Eight of eight children receiving the antivenom showed no signs of scorpion venom in their blood after only one hour and recovered within four hours. Only one in seven children who received the placebo recovered in four hours, and that child was the oldest and heaviest of the group at 42 kilograms. The children not getting the antivenom also needed 65 times as much sedative drug as the others on average, Boyer says...

(Excerpt) Read more at sciencenews.org ...


TOPICS: Culture/Society
KEYWORDS: medicine; scorpion; scorpions; scorpionvenom
Antivenom for Critically Ill Children with Neurotoxicity from Scorpion Stings

It's a FReebie. Check the right sidebar at Science News for suggested reading.

1 posted on 05/15/2009 1:26:13 AM PDT by neverdem
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...

I scanned the NEJM article quickly. The treatment appears to be equine IgG, i.e. horse immunoglobulin G antibodies.


2 posted on 05/15/2009 1:33:31 AM PDT by neverdem (Xin loi minh oi)
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To: neverdem

AWESOME!!!!


3 posted on 05/15/2009 2:34:02 AM PDT by Caipirabob (Communists... Socialists... Democrats...Traitors... Who can tell the difference?)
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To: Caipirabob

How about breeding nontoxic scorpions?


4 posted on 05/15/2009 2:45:24 AM PDT by HiTech RedNeck (Beat a better path, and the world will build a mousetrap at your door.)
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To: HiTech RedNeck
I took a shower with one of these little critters yesterday.....he apparently took a ride to the shower in my hair (YIKES)...after I had been trimming trees. To look down and see one at your feet in the shower takes some getting used to.....


5 posted on 05/15/2009 4:00:24 AM PDT by cbkaty (I may not always post...but I am always here......)
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To: neverdem

It’ll be interesting to see the research results once we factor in the months long wait for treatment that will come with the new 0bamacare program...


6 posted on 05/15/2009 4:32:01 AM PDT by PubliusMM (RKBA; a matter of fact, not opinion. 01-20-2013: Change we can look forward to.)
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To: cbkaty; HiTech RedNeck
I can tell already my kids are going to love Arizona...

I can practically hear the music from the "Psycho Shower Scene" now...

7 posted on 05/15/2009 4:32:39 AM PDT by Caipirabob (Communists... Socialists... Democrats...Traitors... Who can tell the difference?)
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To: cbkaty

GD Bark Scorpions!

Them little black bastards aint nothing though. Ive been hit by one of those and it does hurt like hell for a couple days. Other than that it aint much. Never been nailed by one of those Bark Scorpions though.


8 posted on 05/15/2009 4:42:26 AM PDT by crz
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To: crz
Them little black bastards aint nothing though. Ive been hit by one of those and it does hurt like hell for a couple days.

I have been lucky...never stung...but my wife....one stung her on the neck....she thought she was gonna die....I caught that little Texas bastard....


9 posted on 05/15/2009 4:50:46 AM PDT by cbkaty (I may not always post...but I am always here......)
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To: neverdem
We have one indoor cat that we've never seen go after a mouse, but let her find a scorpion crawling on the floor and she goes NUTS!

The room we find them most has a dark brick floor, so they'd be impossible to see otherwise.

10 posted on 05/15/2009 4:55:15 AM PDT by moondoggie
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To: cbkaty

They do get big in Texas dont they!?
LOL.

Anyway, I was told by several people down there (AZ) that the pulp from a prickly pear will take the pain away. How a person gets the spines off them nasty things to make a poltice is beyond me though.


11 posted on 05/15/2009 4:55:50 AM PDT by crz
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To: neverdem
Equine IgG antibody...they must be making the antivenom in horses. Screws me. I have developed a real allergy to horses and work on them infrequently. Antivenom/toxin toxicity used to be a real problem when horses were the primary source for tetanus and many other vaccine production protocols. Anthrax antitoxin and many snake venom antitoxins are produced in horses also.
12 posted on 05/15/2009 5:00:17 AM PDT by vetvetdoug
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To: vetvetdoug

You’re right. Before human antibody purification was perfected and recombinant DNA technology emerged, lots of antitoxins and antivenins were produced in horses. Humans who were allergic presented a tricky clinical problem.

You have a patient with a potentially fatal illness like a snakebite and in order to save them, you had to risk inducing another potentially fatal problem like anaphylaxis or serum sickness.


13 posted on 05/15/2009 5:07:23 AM PDT by CholeraJoe (Just because I haven't run off and joined the circus, doesn't mean I'm not looking online for jobs.)
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To: crz
pulp from a prickly pear will take the pain away

That may work...just be prepared for a possible allergic reaction.

I simply take an antihistamine before I do any tree or brush removal. In Texas the scorpion likes dead wood/leaves, and bark.... They hide from their prey....I guess we humans can be their prey too....

Also, when getting out of bed at night, wear house shoes because these buggers are active at night. make sure to shake out your shoes....just in case.

14 posted on 05/15/2009 5:13:34 AM PDT by cbkaty (I may not always post...but I am always here......)
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To: CholeraJoe
I say things like Tam Horsfall to young veterinarians and they look at me like I am speaking Greek. When I was in the USAF my Med Lab instructor beat the lab tests to confirm serum sickness into us repeatedly. Of course, serum sickness from tetanus antitoxin in a horse is unlikely since the source of the antitoxin is a horse...
15 posted on 05/15/2009 8:12:08 PM PDT by vetvetdoug
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To: moondoggie

You have scorpions in your HOUSE???

Maybe I’ll shut up about the Iowa winters.


16 posted on 05/16/2009 12:13:22 AM PDT by radiohead (Buy ammo, get your kids out of government schools, pray for the Republic.)
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To: neverdem

Scorpion bites are overrated - Ive been bit several times, my son a couple of times and it ranks less than a bee sting.


17 posted on 05/18/2009 2:53:23 PM PDT by sasafras (TIME FOR A RESURGENCE - FREEDOM IS NOT FREE - NO MORE COMPLAINING - LET'S GET BUSY!)
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To: crz
pulp from a prickly pear will take the pain away. How a person gets the spines off them nasty things

You can burn them off.

18 posted on 05/18/2009 3:08:53 PM PDT by Tammy8 (Please Support & pray for our Troops; they serve us every day. Veterans are heroes not terrorists!)
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