I saw it and noted it, too. Is that a sign of nervousness?
Yes it is; nervous, resulting in dry mouth, resulting in white gooey spittle globs. Note, unlike Obama, who was wildly waving his hand like a little school boy needing to ask the teacher to go potty, McCain was cool, calm and collected throughout the debate... no dry mouth “spittle glob sweat” on him.
Either that or rabies. Having been to DU many times as of late, it's a tough call on that one...