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Researchers Find That Fat Cells Die and Are Replaced With New Ones
NY Times ^ | May 5, 2008 | GINA KOLATA

Posted on 05/04/2008 11:48:37 PM PDT by neverdem

Every year, whether you are fat or thin, whether you lose weight or gain, 10 percent of your fat cells die. And every year, those cells that die are replaced with new fat cells, researchers in Sweden reported Sunday.

The result is that the total number of fat cells in the body remains the same, year after year throughout adulthood. Losing or gaining weight affects only the amount of fat stored in the cells, not the number of cells.

The finding was published online Sunday in the journal Nature.

Obesity investigators say the study raises tantalizing questions: What determines how many fat cells are in a person’s body? When is that number determined? Is there a way to intervene so people end up with fewer fat cells when they reach adulthood? And could obesity be treated by making fat cells die faster than they are born?

“This is a new way of looking at obesity,” said Dr. Lester Salans, an obesity researcher and emeritus professor at Mount Sinai School of Medicine in New York.

But for now, researchers say, they do not have a clue about how to answer those questions.

“There is a system waiting to be discovered,” said Dr. Jeffrey S. Flier, an obesity researcher and dean of Harvard Medical School.

Dr. Flier and other obesity researchers cautioned, though, that even if scientists knew how the fat cell system worked, it was not clear that it would be safe or effective to treat obesity by intervening. One of the hard lessons of the past couple of decades has been that the body has redundant controls to maintain weight.

“I suspect that the body’s regulation of weight is so complex that if you intervene at this site, something else is going to happen to neutralize this intervention,” Dr. Salans...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: adipocytes; fatcells; health; obesity

1 posted on 05/04/2008 11:48:38 PM PDT by neverdem
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To: neverdem
> "...if you intervene at this site, something else is going to happen to neutralize this intervention..."

First intelligent thing I've heard out a researcher in years.

The body is extremely good at maintaining and regulating its internal systems. Screwing around trying to alter things very often gets canceled out, if there's a regulatory mechanism somewhere in there.

2 posted on 05/05/2008 12:29:08 AM PDT by dayglored (Listen, strange women lying in ponds distributing swords is no basis for a system of government!)
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To: neverdem
Nothing to see here. It's already proven that removing fat cells by liposuction makes no difference if you keep eating. The cells that are left just get larger in size to maintain your weight pre liposuction.
3 posted on 05/05/2008 1:52:51 AM PDT by chuckles
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To: neverdem; Judith Anne; Mase
But, I've been told right here on Free Republic that for 'fatties,' losing weight is as simple as burning more calories than taking in.

What could be simpler?

I've also been told that to lose weight 'fatties' should eat foods that are high in sugar, like fruit, and refined flour, such as biscuit mix...

4 posted on 05/05/2008 3:21:14 AM PDT by Gigantor (The last oil refinery built in the United States was completed in 1976...)
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To: chuckles
It's already proven that removing fat cells by liposuction makes no difference if you keep eating. The cells that are left just get larger in size to maintain your weight pre liposuction.

Do you have any source for that?

5 posted on 05/05/2008 9:03:36 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Artificial Stem Cells May Cure Parkinson’s Disease

Stanford researchers synthesize compound to flush HIV out of hiding and into crosshairs

FReepmail me if you want on or off my health and science ping list.

6 posted on 05/05/2008 9:16:02 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem
Damn fat stem cells.
That's the ticket. It has nothing to do with my poor exercise regimen.
7 posted on 05/05/2008 9:37:12 PM PDT by rmlew (Down with the ersatz immanentization of the eschaton known as Globalism.)
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To: neverdem

Got it from Discovery TV show about Plastic Surgery.


8 posted on 05/06/2008 12:12:20 AM PDT by chuckles
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To: neverdem; chuckles

I have never heard of the expanding fat cell phenom either.


9 posted on 05/06/2008 6:13:59 AM PDT by Rennes Templar ( Never underestimate the difficulty of changing false beliefs by facts.)
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To: Gigantor
I've also been told that to lose weight 'fatties' should eat foods that are high in sugar, like fruit, and refined flour, such as biscuit mix...

Rejecting the Archer Daniels Midland Diet is medical heresy - you could end up being publicly flogged by farm-state Republicans. ;)

10 posted on 05/06/2008 6:22:45 AM PDT by Mr. Jeeves ("One man's 'magic' is another man's engineering. 'Supernatural' is a null word." -- Robert Heinlein)
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To: Gigantor
But, I've been told right here on Free Republic that for 'fatties,' losing weight is as simple as burning more calories than taking in.

Paraphrasing the great social arbitor of our time, Homer Simpson, "FReepers, is there nothing they don't know?"

;)PaMom

11 posted on 05/06/2008 9:26:14 AM PDT by PennsylvaniaMom (I could never 'Keep Sweet' I am a bitter Pennsylvanian)
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To: Mr. Jeeves
Rejecting the Archer Daniels Midland Diet is medical heresy - you could end up being publicly flogged by farm-state Republicans

Why should they care if we eat their crops directly, or after they've been run through a cow, chicken or pig? Actually they'd have more demand for the grain if we ate more meat, because that's a more inefficient process. IOW, lots more grain gets used up feeding animals for people to eat than if people ate the grain directly.

12 posted on 05/06/2008 4:59:24 PM PDT by El Gato ("The Second Amendment is the RESET button of the United States Constitution." -- Doug McKay)
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To: Mr. Jeeves
Rejecting the Archer Daniels Midland Diet is medical heresy - you could end up being publicly flogged by farm-state Republicans

Why should they care if we eat their crops directly, or after they've been run through a cow, chicken or pig? Actually they'd have more demand for the grain if we ate more meat, because that's a more inefficient process. IOW, lots more grain gets used up feeding animals for people to eat than if people ate the grain directly.

13 posted on 05/06/2008 4:59:25 PM PDT by El Gato ("The Second Amendment is the RESET button of the United States Constitution." -- Doug McKay)
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