And he said unto them, This is my blood of the new testament, which is shed for many. Verily I say unto you, I will drink no more of the fruit of the vine, until that day that I drink it new in the kingdom of God. Mark 14:24-25
And he took the cup, and gave thanks, and said, Take this, and divide [it] among yourselves: For I say unto you, I will not drink of the fruit of the vine, until the kingdom of God shall come. Luke 22:17-18
Leaven was always symbolic of evil and therefore could not have been used to ferment the "fruit of the vine" in the ordinance of the Communion.
http://www.biblestudy.org/basicart/chrdrink.html
Amazing how it took the Christian church nearly 2000 years to figure this out. You do realize that before the start of the Temperance movement in the USA, Protestent churches (and of course Catholic and Orthodox) used wine for Communion, right? It was Welch's pasteurization of grape juice in 1869 combined with the secular Temperance movement that prompted the change, not some remarkable new exegesis of the New Testament.