[GregH]

Asian and Middle eastern airlines have already placed orders for the A380 and more would come in once Airbus delivers those initial orders. US airlines are behind the game, years behind other major international airlines, so it would take a while for an American airline to introduce A380 in its routes.

[Clemenza]

There is no reason to. Most airlines would prefer the flexibility of mid-sized aircraft for international routes, as they can easily be transitioned between routes based on landing capacity (not every airport can handle the A380) or demand (you can't always fill a 747 or A380).

Still waiting to see what they will do with the A350 program.