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Cells Passed From Mother To Child May Be First Step In Developing New Treatments For Type 1 Diabetes
Science Daily ^ | January 23, 2007

Posted on 01/24/2007 9:07:08 PM PST by hocndoc

For the first time, scientists have discovered that cells passed from mother to child during pregnancy can differentiate into functioning islet beta cells that produce insulin in the child. The same study also found that maternal DNA was found in greater amounts in the blood of children and young adults with Type 1 diabetes than their healthy siblings and a control group, implying that they may be attempting to repair damaged tissue.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Business/Economy; Culture/Society; News/Current Events
KEYWORDS: diabetes; health; microchimerism; research; stemcells
We have further proof of yet another naturally occuring adult stem cell line that contributes to treatment of diabetes in the recipient long after introduction of the cells and without immune rejection.

Scientists have reported in the "Proceedings of the National Academies of Science (Free abstract) about the discovery that mother's stem cells may cross the placenta and that- in those babies who grow up and later develop Type I diabetes ("Juvenile Diabetes," or "Insulin Dependent Diabetes Mellitis") - some of those cells help repair the pancreas and make insulin.

The researchers thought they would find evidence that the maternal cells might actually cause the diabetes, but instead found that the maternal cells had become beta islet cells of the pancreas, the cells which produce insulin, and were functioning in a beneficial way, years later.

1 posted on 01/24/2007 9:07:12 PM PST by hocndoc
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To: MHGinTN; neverdem; Coleus; cpforlife.org; Mr. Silverback; Brad's Gramma; wagglebee

There are a couple of great stories today concerning diabetes. I've blogged about both of them. There's this story about maternal cells that cross the placenta and are recruited and functional in diabetics, and the report out of Korea about beta islet cells from cord blood.


2 posted on 01/24/2007 9:13:02 PM PST by hocndoc (http://www.lifeethics.org/www.lifeethics.org/index.html)
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To: hocndoc

Wow, interesting! Once on a stem cell discussion thread, when I brought up the fact that a mother carries cells from her children for the remainder of her life, someone pointed out how that would apply to Jesus and His Mother, Mary. Now, it appears the gift runs the other way also.


3 posted on 01/24/2007 9:43:35 PM PST by MHGinTN (If you can read this, you've had life support. Promote life support for others.)
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To: 2ndMostConservativeBrdMember; afraidfortherepublic; Alas; al_c; american colleen; annalex; ...
Unborn Children May "Cure" Mothers' Diseases Via Fetal Stem Cells
 

Adult Pancreas Stem Cells Can Make Insulin
Pig Cells 'May Reverse Diabetes'
New Applications For Cord Lining Stem Cells - Diabetes And Wound Healing
Diabetes In Mice Cured Using Non-Embryonic Sources 
Diabetes Foundation Loses Its Way The Pro-Abortion Juvenile Diabetes Research Foundation
Stem Cells May Help Bergen Boy Fight Diabetes
Adult Stem Cell Research Breakthrough Produces Insulin For Diabetics
Diabetes In Mice Cured Using Non-Embryonic Sources
Adult Pancreas Stem Cells Can Make Insulin
A Stem-Cell Defection, A Congressman Educates.
Stem cell cure hope for diabetes


4 posted on 01/24/2007 10:07:19 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, birds, insects)
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To: hocndoc

Maternal microchimerism has fascinating implications for immunology and transplant surgery.


5 posted on 01/24/2007 11:24:38 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem
What of fetal microchimerism, which is universal?
6 posted on 01/24/2007 11:46:28 PM PST by rmlew (Having slit their throats may the conservatives who voted for Casey choke slowly on their blood.)
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To: IslandJeff

Type 1 diabetes ping.


7 posted on 01/25/2007 12:57:21 AM PST by FreedomCalls (It's the "Statue of Liberty," not the "Statue of Security.")
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To: FreedomCalls; austinmark; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
Image Hosted by ImageShack.us

Type I Diabetes Ping List
FR mail me to add yourself! (Type IIs welcome, too.)


Thanks to FreedomCalls for the heads-up!
8 posted on 01/25/2007 1:06:07 AM PST by IslandJeff (that for every right there is a duty, for every benefit an obligation)
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To: hocndoc
Does this mean I'm a Type I diabetic cause I'm a mommas boy? jk. Good news. I also liked the one about the researcher who found spleens generated stem cells that replaced islet cells (in mice). Couldn't find the orig. article, but there is this one.
9 posted on 01/25/2007 1:21:01 AM PST by amchugh
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To: MHGinTN; Coleus

What I learned from my last doc appointment (now that I'm damned near forty and insulin-dependent since 1994) is that mitochondrial RNA is consistent along MATERNAL lines.

Essentially, everyone's last name is "Eve", if you care to apply paternal conventions to biology.

What that means, to middle-aged childless men, is that, in the scheme of cultural-biology, the pressure to produce heirs is a cultural construct, exclusively. Childless eligible men rejoice, and step-dad with pride and equal determination!


10 posted on 01/25/2007 1:26:42 AM PST by IslandJeff (that for every right there is a duty, for every benefit an obligation)
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To: IslandJeff

CAVEAT:

Men, obviously, pass along secondary characteristics to heirs, including nasty little predispositions like Diabetes Mellitus. In the male's gamete, paternal mitochondrial RNA info is, essentially, stripped-off, and only DNA factors are passed along.

[Any geneticists here? Can I get a hand? I'm an accountant, with hamhanded knowledge, here!]


11 posted on 01/25/2007 1:55:26 AM PST by IslandJeff (that for every right there is a duty, for every benefit an obligation)
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To: amchugh

It means you might be less affected by diabetes if you're more of a moma's boy.

Since I'm a moma, let me say that you are and always will be your moma's boy. And now, you may owe her even more gratitude. So call her.


12 posted on 01/25/2007 9:14:44 AM PST by hocndoc (http://www.lifeethics.org/www.lifeethics.org/index.html)
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To: hocndoc

Thanks for the 'ping'...good news (all news, really) is very welcome.

Ever hopeful here :)


13 posted on 01/25/2007 10:05:12 AM PST by krunkygirl
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