Posted on 12/02/2006 8:27:33 PM PST by neverdem
Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem - the appearance of brain tumors - that scientists are now working to solve. The study is featured on the cover of the November issue of Nature Medicine.
The work was reported by neurologist Steven Goldman, M.D., Ph.D., professor of Neurology at the University of Rochester Medical Center and chief of its Division of Cell and Gene Therapy, and Neeta Roy, Ph.D., assistant professor of Neurology at Cornell's Weill Medical College.
"The results are a real cause for optimism," said Goldman. "These animals with severe Parkinson's symptoms had a dramatically improved outcome after treatment. Now we have a new problem to work on, how to achieve the same benefit without creating tumors. But we expect to be able to solve this problem within the next year or two, using new approaches to cell sorting that we've been developing."
"All in all, this is the way medical discoveries move forward: One step at a time."
Goldman has spent much of his career creating ways to isolate stem cells, discovering the molecular signals that help determine what specific types of cells they become, and then re-creating those signals to direct the cells' development. It's the versatility of stem cells that make them so attractive. If scientists like Goldman are successful directing their development, such cells could provide a ready source of cells custom made to treat a given disease - for instance, myelin-producing cells for multiple sclerosis, or the specific types of cells that die in patients with Parkinson's or Huntington's diseases.
In the experiment reported in Nature Medicine, Goldman, Roy and colleagues set out to grow brain cells called neurons that produce dopamine, a crucial brain chemical lacking in patients with Parkinson's. They began by isolating human embryonic stem cells, then using genes such as "sonic hedgehog" and fibroblast growth factor 8 that make chemicals in the normal brain environment. Such signals are the body's natural way of directing stem cells to develop into the specific cells needed.
Past attempts at using stems cells to make this type of neuron had achieved modest success, but only relatively small numbers could be produced in tissue culture. To improve upon this, Roy and Goldman attempted to re-create the natural environment of the developing brain as much as possible, so it would seem to the stem cells that they were developing in the part of the brain where dopamine neurons are normally made. The team did so by raising the cells together with brain cells known as astrocytes, which had come from the same brain region. These cells have long been known to play a crucial role nourishing neurons.
The result was that more than two-thirds of the stem cells developed into precisely the type of cell needed to treat Parkinson's disease - dopamine-producing neurons. That percentage is far higher than any previous experiment had achieved.
The team then injected the cells into the brains of rats with Parkinson's-like symptoms, and watched for 10 weeks. While rats with the disorder walked in circles when prompted to move, as if they were chasing their tails, rats transplanted with the new cells recovered normal function and eventually stopped walking in circles. By eight weeks after treatment, the tail-chasing behavior ended completely, and they were walking and running normally.
Yet when the brains of the animals were examined, the team found tumors within the brain grafts. Goldman said the tumors sprang from stem cells that had started on the road to becoming neurons, but then stalled in their development and grew out of control. The team is working on ways to filter out those cells, to reap the benefits while avoiding the side effects of the approach.
"The appearance of tumors was disappointing, but not surprising," said Goldman. "The goals of this experiment were to create a population of cells that had many more dopamine neurons than previous attempts yielded, and to measure whether a group of cells with so many of these neurons would yield real-life benefits in terms of behavior. We accomplished both tasks. The cells improved the disease symptoms dramatically, beyond what we expected.
"In this first attempt of the technology, we did not attempt to try to absolutely purify the cell population that was transplanted - thus the brain tumors. The experiment confirmed that we need to have an absolutely pure cell population, and we are working on ways to do that."
http://www.urmc.rochester.edu
A rather disingenuous way to downplay the persistent problem of teratomas.
Is michael j fox still shaking?
So once we solve the little problem of tumors, we'll be able to improve Parkinson's in rats with human embryonic stem cells - and what about humans?.......
"When I first read the title I thought they were discriminating against Republicans..."
LMAO
How many dead babies will it take to "solve" this problem?
God forbid we should use rat embryos. PETA would get upset.
lol!
SC Ping
"It's the answer to ALL our health issues and just think those aborted fetuses will help save the lives of others. Pregnant women can serve the greater good of humankind by aborting their fetus. It's a great new world, yes, a brave new world."
Dr. Frank N. Stein, Research Fellow and Medical Ethicist
Good gracious--I wonder how an UNETHICAL" Doctor would put it? The mind boggles.....
"We have good news and bad news."
"The good news is we cured your disease."
"The bad news is we gave you a worse one."
"Oh, and by the way, we killed unborn babies to do it."
The Testimony of Dr. Michel F. Levesque, M.D., on Adult Stem Cells treating Parkinson's Disease
Potential= Brain tumors. Now that is some real positive news. /s
The symptoms sound just like a group of DU'ers with the mental disorder of liberalism.
I would've hoped that any attempt to produce a Master Race would've died along with Adolf Hitler and his merry band of eugenicists.
brain tumors are an improvement ????
This is a complex issue. They are making strides using stem cells from adults to hopfully cure the same adult. We lost some seats in this last election due to this. It isn't a black and white issue.
I would say that as long as the donor is not terminated, move at full speed ahead. The promises are immense.
Missouri passed a ballot measure on this in the last election. California already has. Florida is seeking to put it on the ballot in the next election.
Republicans need to get up to speed on this issue. "Its about killing babies" rhetoric isn't going to work with the American public.
Stem cell trial may bring end of back pain for millions
Discovery of cardiac stem cells may advance regenerative heart therapy
Some of Coleus' recent posts. FReepmail me if you want on or off my health and science ping list.
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