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Stem cell cure hope for diabetes
BBC ^ | 12 November 2006 | BBC

Posted on 11/11/2006 11:04:13 PM PST by batter

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To: Kelly_2000

"this is not the crux the of the matter at all"

Yes it is... The money to be made is through drugs. In order to market a drug, you must be able to mass produce it. You cant do that if the treatment has to be customized for each patient.


21 posted on 11/12/2006 6:58:50 AM PST by babygene
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To: Coleus; nickcarraway; narses; Mr. Silverback; Canticle_of_Deborah; TenthAmendmentChampion; ...
Pro-Life PING

Please FreepMail me if you want on or off my Pro-Life Ping List.

22 posted on 11/12/2006 9:11:25 AM PST by cpforlife.org (A Catholic Respect Life Curriculum is available at KnightsForLife.org)
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To: uptoolate

God bless your son. A very wise young man.


23 posted on 11/12/2006 9:55:29 AM PST by Fudd Fan (Liberal RATs will get us all killed.)
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To: Fudd Fan

Thank You


24 posted on 11/12/2006 10:42:55 AM PST by uptoolate (Their 'innocent' civilian is their next suicide bomber)
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To: soccer8
Adult stem cells make more sense anyway. Embryonic stem cell are not a full match unless they come from your identical twin and so you still will have the same rejection problems as with any other transplant.

Adult stem cells come from you. No rejection problems, no drugs, no break down. They actually are a cure rather then a patch that gives you a small extension but with major drawbacks.

25 posted on 11/12/2006 10:49:45 AM PST by Harmless Teddy Bear (Those who call their fellow citizens Sheeple are just ticked they were not chosen as Shepherds)
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To: uptoolate
Thanks for your post! It just lifted my heart and spirit to hear how well your son is doing!

Yes, there are times when the control is not there, and you just don't understand it, despite everything you've done...hormones & growth spurts seemed to cover it!

You are so right about the worry part. And I'm glad you've learned that lesson!

Wow, I remember the very instant I realised that either I was going to put aside all the worries and obsessing about this, that, and the other thing, or I was going to go crazy. AND how would THAT benefit my dear son?

It was a lesson which applies to so much in life, too. Let go, and let God take the burden.

Our son enjoyed summer camp for a few years too.

We all learned to balance his needs with the whole of our lives, together as a family and individually.

We learned perspective, commonsense, trust and so much else. Definitely the "lemon/lemonade" lesson.

Somewhere along the way, you realize you've raised a child who happens to have diabetes, not necessarily a diabetic child...

Thanks for your comments! Take care, and all the best to you, him, and the rest of your family.

26 posted on 11/12/2006 11:58:06 AM PST by Molly Pitcher (We are Americans...the sons and daughters of liberty...*.from FReeper the Real fifi*))
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To: soccer8; 2ndMostConservativeBrdMember; afraidfortherepublic; Alas; al_c; american colleen; ...

Diabetes In Mice Cured Using Non-Embryonic Sources 
Adult Pancreas Stem Cells Can Make Insulin
Pig Cells 'May Reverse Diabetes'

New Applications For Cord Lining Stem Cells - Diabetes And Wound Healing
Diabetes In Mice Cured Using Non-Embryonic Sources 
Diabetes Foundation Loses Its Way The Pro-Abortion Juvenile Diabetes Research Foundation  

Stem Cells May Help Bergen Boy Fight Diabetes
Adult Stem Cell Research Breakthrough Produces Insulin For Diabetics

Diabetes Foundation Loses Its Way 


27 posted on 11/12/2006 12:34:28 PM PST by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, geese, algae)
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To: babygene
You cant do that if the treatment has to be customized for each patient.

In the traditional pharmacological sectors and markets this is true, but you are describing stem cell therapies that are NOT based on traditonal paradigms. Nor are they limited to current mass market paradigms. Growing new organs for patients from totopotent cells THEY posses would not be "mass market" viable either. Yet this emerging industry and technique is coming. You seem to be starting your hypothesis on a flawed premise and making several erroneous assumptions.

28 posted on 11/12/2006 12:43:06 PM PST by Kelly_2000 ( Because they stand on a wall and say nothing is going to hurt you tonight. Not on my watch)
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To: soccer8

Hope or hype? Which is it? Con job?


29 posted on 11/12/2006 12:44:10 PM PST by RightWhale (RTRA DLQS GSCW)
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To: Kelly_2000
The ONLY reason fetal stem cells are being pushed is to enable mass marketing of a stem cell solution.

I'm surprised you don't see this...
30 posted on 11/12/2006 1:37:24 PM PST by babygene
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To: Molly Pitcher; uptoolate; Marie; misterrob

My 15 yo son was dxed at age 2 1/2. He just completed his Eagle project a few weeks ago.


31 posted on 11/12/2006 2:48:49 PM PST by MarMema
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To: RightWhale
Hope, IMO. Adult stem cells have been quite promising. Especially, where no immunosuppression is required as the cells come from the patients body rather than a donor. However, as the article states, researchers also need to find "a way to prevent transplanted cells from being destroyed by the body" (an autoimmune response in Type I diabetics kills the islet cells) for this to work for everyone (I think current figures are about 1 in 7 islet cell transplants are successful (ie the autoimmune or regular immune response to the transplant kills the new cells in 6 of 7 patients).

The above also brings up another question (in my mind): since these cells come from the actual patient (rather than donor) will success improve the current 1 in 7 figure? Will the genetically identical 'own body' cells suppress or be ignored by the autoimmune response (note: medical folks believe something triggers the response, but they are not certain what that may be)?

I really don't see this as a sham study but a good one. Time will tell.

32 posted on 11/12/2006 6:48:24 PM PST by batter ("Never let the enemy pick the battle site." - Gen. George S. Patton)
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To: MarMema; Molly Pitcher; uptoolate; Marie; misterrob
It's nice to hear from other affected FReepers. I'm sure we'll all continue to pray for these an other researchers working towards ethical cures for this and other diseases.

Your heartfelt statements of support to one another are wonderful. Yet another reason why FR is such a great place to come to.

33 posted on 11/12/2006 7:00:49 PM PST by batter ("Never let the enemy pick the battle site." - Gen. George S. Patton)
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To: uptoolate
I know what you're going through! My son's last A1C was 8.8. (normal is 7.2) But his BG's were unstable from the beginning.

It turns out we have other autoimmune diseases in the family. (thyroid, Addison's, alopicia) Looking into all that, I found this:

http://autoimmunedisease.suite101.com/blog.cfm/1534

Here's one small part of the article that you may find interesting:

"However, patients with diabetes who begin to experience unstable or poorly controlled glucose levels should be tested for both adrenal and thyroid antibodies. Patients with APS2 often develop other autoimmune conditions although these disorders are less likely to occur in APS2 compared to APS1. These disorders include vitiligo, myasthenia gravis, thrombocytopenic purpura, Sjogren's syndrome, rheumatoid arthritis, alopecia, hypergonadotropic hypogonadism, pernicious anemia, atrophic gastritis, hypophysitis, and primary antiphospholipid syndrome."

I'm taking my son in at the end of the month to make sure the rest of his endocrine system isn't messing up his blood sugar.

He's 13 and puberty isn't helping his situation!!

One more thing! As a parent to a parent I have to ask you one thing; how do you sleep? I've got myself on a 2-10AM sleep schedule to make sure he's stable through the night. He gets himself off to school in the morning and can pretty much take care of himself during the day. Other parents keep reassuring me that he'll wake up naturally if he's low, but three nights ago I found him wandering in the kitchen, eating a pickle. He was like a sleep walker. I tested him and he was 43. He was in *no* condition to make a decision, or even realize he was low. I know I can't trust his brain to function when he's like that.

I know that many parents of diabetic children are single or work. I can't imagine how they deal with the nights.

34 posted on 11/12/2006 8:25:20 PM PST by Marie (Enjoy it Dems. It won't happen next time.)
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To: soccer8
However, as the article states, researchers also need to find "a way to prevent transplanted cells from being destroyed by the body"

Actually, encapsulated Islets take care of that problem. But then you wouldn't need to bother with developing Islets from the patient's own stem cells. Xenotransplantation would be cheaper and more readily available.

35 posted on 11/12/2006 8:29:14 PM PST by Marie (Enjoy it Dems. It won't happen next time.)
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To: Blue Jays; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
Image Hosted by ImageShack.us


Type I Diabetes Ping List
FR mail me to add yourself! (Type IIs welcome, too.)

Thanks to Blue Jays for the heads-up.
36 posted on 11/12/2006 9:14:38 PM PST by IslandJeff (FR mail me to be added to the Type I Diabetes ping list)
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To: Marie

"As a parent to a parent I have to ask you one thing; how do you sleep?"

Zach is homeschooled so we don't have a strick schedule. Most of the time he's in bed by 11:00 but usually reads or does some schoolwork for a while. We try to get him up between 7:30 and 8:00.

My wife hits the sack around 10:00. I'm usually "uptoolate" till around 1:00 or 2:00. We both make sure Zach checks his blood sugar. He's on the pump so with that reading of 27 the other night we thought it best to cut back on his Basil rate. Rather have him a little high than too low. This was the first time he's ever been that low during the night. Although he did sleep in 'till 10:30. That's 2 1/2 hours of inactivity while his pump is programmed to give him a higher dose of insulin because he is usually active.

It is all trial and error. What works this year may not work the same next year due to changing body chemistry.

When it is all said and done, the last thing I do before closing my eyes is pray for him and us and just leave him in God's hands. Zach is God's child. I'm only watching him 'till Jesus says the mansion is ready for occupancy.


37 posted on 11/12/2006 9:48:32 PM PST by uptoolate (Their 'innocent' civilian is their next suicide bomber)
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To: babygene
The ONLY reason fetal stem cells are being pushed is to enable mass marketing of a stem cell solution.

I'm surprised you don't see this...

I am a microbiologist and I am afraid I see alternative business models and revenue streams proposed, for future treatment regimes and protocols you are apparently unaware of. revenue models are not dependent on generic protocol. Many existing models exist in areas of medicine that disagree with your opinion.

38 posted on 11/13/2006 1:54:13 PM PST by Kelly_2000 ( Because they stand on a wall and say nothing is going to hurt you tonight. Not on my watch)
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To: Kelly_2000

"I am a microbiologist and I am afraid I see alternative business models and revenue streams proposed, for future treatment regimes and protocols you are apparently unaware of"

So... What business models and revenue stream would make fetal stem cells a better choice than adult cells? Why the push for fetal?


39 posted on 11/13/2006 3:42:41 PM PST by babygene
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To: uptoolate
He said, "Why would you kill someone to allow me to live? Jesus did that once, and that was enough for me?"

Hey, he's got it! Praise The LORD!!!

40 posted on 11/13/2006 10:49:57 PM PST by Bellflower (A Brand New Day Is Coming!)
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