Mice Deaths Are Setback in Gene Test

NY Times ^ | May 25, 2006 | ANDREW POLLACK

[neverdem]

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar, Mark A. Kay

Nature 441, 537-541 (25 May 2006) Letters to Editor

[Spruce]

I kill any, and all mice in my jeans. But I guess I'm old-fashioned.

btw, I use a shoe.

[DannyTN]

Three blind mice
Three blind mice
See how they run,
See how they run,
They all ran after the geneticist's wife,
who poisoned their liver and ended their life,
Three blind mice.

Yep I'm up too late.

[Ichneumon]

Ping

[neverdem]

First vaccine to fight bird flu is here

Researcher says human-to-human infection of bird flu taking place in Indonesia The complete text is not as assertive as the title.

Giant earthworm resurfaces after nearly two decades

Invisibility cloaks are in sight

FReepmail me if you want on or off my health and science ping list.

[NotJustAnotherPrettyFace]

Just wait.... all the PETA people will be all over this one!

[ordinaryguy]

Dr. Kay and his team, led by a postdoctoral researcher, Dirk Grimm, wanted to cure mice of hepatitis B, not to kill them.

I'm glad the NY Times clarified that.

[taxesareforever]

A large number of mice died unexpectedly in a test of a new technique for inactivating genes

In the last three weeks 10 mice died expectantly in a trapping technique for separating them from their genes close to my home. :)

[Lancer_N3502A]

Dr. Kay lied and mice died. Where's the outrage?

[PatrickHenry]

Archive

[Harmless Teddy Bear]

the technique, also called RNAi for short, caused liver poisoning and death in mice.

Now that is truly building a better mouse trap.

A bit labor intensive but it has commercial possibilities

[ahayes]

Drat.

At least it will retain its usefulness in vitro for gene silencing even if it never becomes useful pharmaceutically.

[Raycpa]

[ovrtaxt]

it could overtax the cell's ability to process its own microRNA.

How bout that, they spelled it wrong.

[Izzy Dunne]

I kill any, and all mice in my jeans.
btw, I use a shoe.

Take my word for it - don't try using an ice pick.

[DannyTN]

"led by a postdoctoral researcher, Dirk Grimm"

Does he have a brother?

[jammer]

new technique for inactivating genes

You use a shoe, but I remind you that this is research on a NEW technique for inactivating genes, not your old, tried-and-true, way. Sounds like it worked, in a way. ~:)

[AntiGuv]

FutureTechPing!

An emergent technologies list covering biomedical research, fusion power, nanotech, AI robotics, and other related fields. FReepmail to join or drop.

[Lazamataz]

I kill any, and all mice in my jeans.

You are missing out.

[Old Professer]

Now why does this bring up the commercial in my mind of the guy trying to figure out what that extra wall switch does???