[Cronos]

not really -- the numbers they killed directly were small, but since the Spaniards were the first Europeans, they brought along with them European diseases like Smallpox that killed off natives in large numbers. By the time the English came, the immunity had spread to the northern natives

[dennisw]

You'll like this. The pigs the Spanish brought were a major vector for disease:

http://shs.westport.k12.ct.us/jwb/collab/1941.pdf