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US develops lethal new viruses
New Scientist ^ | 19:00 29 October 03 | Staff

Posted on 10/29/2003 1:25:12 PM PST by glorgau

A scientist funded by the US government has deliberately created an extremely deadly form of mousepox, a relative of the smallpox virus, through genetic engineering.

The new virus kills all mice even if they have been given antiviral drugs as well as a vaccine that would normally protect them.

The work has not stopped there. The cowpox virus, which infects a range of animals including humans, has been genetically altered in a similar way.

The new virus, which is about to be tested on animals, should be lethal only to mice, Mark Buller of the University of St Louis told New Scientist. He says his work is necessary to explore what bioterrorists might do.

But the research brings closer the prospect of pox viruses that cause only mild infections in humans being turned into diseases lethal even to people who have been vaccinated.

And vaccines are currently our main defence against smallpox and its relatives, such as the monkeypox that reached the US this year. Some researchers think the latest research is risky and unnecessary.

"I have great concern about doing this in a pox virus that can cross species," said Ian Ramshaw of the Australian National University in Canberra on being told of Buller's work.

Ramshaw was a member of the team that accidentally discovered how to make mousepox more deadly (New Scientist, 13 January 2001). But the modified mousepox his team created was not as deadly as Buller's.

Since then, Ramshaw told New Scientist, his team has also created more deadly forms of mousepox, and has used the same method to engineer a more deadly rabbitpox virus.

But this research revealed that the modified pox viruses are not contagious, he says. That is good news in the sense that these viruses could not cause ecological havoc by wiping out mouse or rabbit populations around the world if they escaped from a lab.

However, this discovery also means some bioterrorists might be more tempted to use the same trick to modify a pox virus that infects humans. Such a disease, like anthrax, would infect only those directly exposed to it. It would not spread around the world and rebound on the attackers. But there is no guarantee that other pox viruses modified in a similar way would also be non-contagious.

Ramshaw's team made its initial discovery while developing contraceptive vaccines for sterilising mice and rabbits without killing them. The researchers modified the mousepox virus by adding a gene for a natural immunosuppressant called IL-4, expecting this would boost antibody production.

Instead, the modified mousepox virus was far more lethal, killing 60 per cent of vaccinated mice. The addition of IL-4 seems to switch off a key part of the immune system called the cell-mediated response.

Now Buller has engineered a mousepox strain that kills 100 per cent of vaccinated mice, even when they were also treated with the antiviral drug cidofovir. A monoclonal antibody that mops up IL-4 did save some, however.

His team "optimised" the virus by placing the IL-4 gene in a different part of the viral genome and adding a promoter sequence to maximise production of the IL-4 protein, he told a biosecurity conference in Geneva last week.

Buller has also constructed a cowpox virus containing the mouse IL-4 gene, which is about to be tested on mice at the US Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland.

Cowpox infects people, but Buller says the IL-4 protein is species-specific and would not affect the human immune system. The experiments are being done at the second-highest level of biological containment.

Ramshaw says there is no reason to do the cowpox experiments, as his group's work on rabbits has already shown the method works for other pox viruses. While viruses containing mouse IL-4 should not be lethal to humans, recombinant viruses can have unexpected effects, he says. "You'd hope the combination remains mouse-specific."

Why his group's engineered viruses are not contagious is a mystery, he says. It is not, for instance, because the host dies faster than usual, taking the virus with it. But his findings could explain why pox viruses containing IL-4 have never evolved naturally, even though the viruses frequently pick up genes that affect their host's immunity.

Despite the concerns, work on lethal new pox viruses seems likely to continue in the US. When members of the audience in Geneva questioned the need for such experiments, an American voice in the back boomed out: "Nine-eleven". There were murmurs of agreement.


TOPICS: Foreign Affairs; Government
KEYWORDS: bioterrorism; biowarfare; bioweapons; buller; cidofovir; il4; immuneresponse; mice; mousepox; pox; ramshaw; smallpox
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Comment #21 Removed by Moderator

To: Darnright
As of now. And what happens when we get some Bill Clinton type who shares this technology with other countries?

Good question.

What's the answer? ;-)

22 posted on 10/29/2003 2:09:34 PM PST by Scenic Sounds (Me caigo a mis rodillas y hablo a las estrellas de plata. "¿Qué misterios usted está encubriendo?")
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To: RussianConservative
"How this different then program of many other nation who constantly condemned for WMD work?"

The countries we want to stop WMD work, such as Iran and North Korea are either enemies of the United States, or enemies of our allies like Japan, South Korea, and Israel.

Nothing hypocritical about this - we want ourselves to be better armed than our possible military opponents.

PS: It's not clear this scientist was working for the US Government or working for an independent private laboratory.
23 posted on 10/29/2003 2:22:34 PM PST by Pubbie (Vote "No" On Recall, "Yes" On Bustamante)
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To: RussianConservative
"How this different then program of many other nation who constantly condemned for WMD work?"

Will you quit pointing out our double standards when we are trying to bring freedom to the world?

It comes down to who are you going to trust.
These guys? or...

Or the freely elected leadership and institutions of America?

OK, Well then just choose the lesser of the two evils. :)

24 posted on 10/29/2003 2:40:09 PM PST by DannyTN (Note left on my door by a pack of neighborhood dogs.)
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To: Centurion2000
Here's the thread on the Demon in the Freezer:

http://www.freerepublic.com/focus/fr/598296/posts
25 posted on 10/29/2003 3:14:15 PM PST by Domestic Church (AMDG...)
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To: aristeides
"How does research for offense differ from research for defense?"

There is a possibility that something like this is developed to head off a worse situation...think of mice as vectors of something we can't stop.
26 posted on 10/29/2003 3:17:33 PM PST by Domestic Church (AMDG...)
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To: DannyTN
And what happen if mad bomber Clark become president of US next? Will all germs just go away?
27 posted on 10/29/2003 4:20:20 PM PST by RussianConservative (Hristos: the Light of the World)
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To: Centurion2000
How hard to turn defense into offense if all it take is release?
28 posted on 10/29/2003 4:21:36 PM PST by RussianConservative (Hristos: the Light of the World)
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To: Scenic Sounds
The adults are in charge of ours.

Can you guarentee all future administration adult?

29 posted on 10/29/2003 4:23:12 PM PST by RussianConservative (Hristos: the Light of the World)
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To: RussianConservative
Can you guarentee all future administration adult?

No, of course not. ;-)

30 posted on 10/29/2003 4:25:45 PM PST by Scenic Sounds (Me caigo a mis rodillas y hablo a las estrellas de plata. "¿Qué misterios usted está encubriendo?")
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To: RussianConservative
You sure do complain about the US boogeyman alot. Look just calm down, the United States is not going to attack other nations with germ warfare. End of story, ok? I mean what exactly is your line of thinking here? That we're gonna attack Russia with anthrax? Gimme a break.
31 posted on 10/29/2003 4:33:19 PM PST by Chaseman
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To: RussianConservative
How hard to turn defense into offense if all it take is release?

Defense to offense requires retooling a production like to make the bio weapon and then altering the warheads to accept new weapons ... THEN release.

32 posted on 10/29/2003 4:35:19 PM PST by Centurion2000 (Virtue untested is innocence)
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To: BabaOreally
This is so bad. So stupid. Now that we've told the whole world how this works, any bio Grad student can do this "work" in a basement! Cat's out of the bag!

The IL-4 mousepox stuff has been public for quite a while. My recollection is that it was done first by some researchers down in Australia.

My personal opinion is that 12 Monkeys probably got it right. If (when?) a species killer bug gets released, it will be a westerner that does it. You need a combination of ideology and capability.

There just aren't that many folks in the middle east with the labs and knowhow. But there's lots of hard-Greens in universities and some of them have molecular biology degrees. Wiping humans off the face of the Earth is, in their mind, a good thing.

OTOH, Islamists want to rule the world--wiping out the human race would stand in the way of that goal.

33 posted on 10/29/2003 5:04:51 PM PST by ModelBreaker
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To: RussianConservative
I think we could worry about the situation in your neck of the woods as well...at least as likely to be problematic. I don't think either your nation or ours would use this stuff in offense because there are less dangerous, more effective and more advanced tools in our toolboxes (not to mention the cold war is over.) It's the rogue nations/powers that we have to watch and be prepared to defend against. It's a nasty situation.
34 posted on 10/29/2003 5:07:36 PM PST by Domestic Church (AMDG...)
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To: tkathy
Sooner or later some terrorist will get their hands on this and our govt will whine and carry on. Too stupid.
Lessee ... they gave everything but the guy's phone number ... hope the lab security is better than most I saw when in college. ;-(
35 posted on 10/29/2003 5:11:33 PM PST by Tunehead54 (Do not believe everything you read! Suspicious sources: NYT, WP, LAT. You have been warned.)
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To: All

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36 posted on 10/29/2003 5:11:50 PM PST by Bob J (www.freerepublic.net www.radiofreerepublic.com...check them out!)
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To: Domestic Church
Again this remind of movie 12 Monkey
37 posted on 10/29/2003 5:18:29 PM PST by RussianConservative (Hristos: the Light of the World)
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Comment #38 Removed by Moderator

To: RussianConservative
911 justify creation of biological agent? How this different then program of many other nation who constantly condemned for WMD work?

That's easy. With the regime changes brought on by 9/11, the US now has new potential clients to sell these things too! Isn't that wonderful?

39 posted on 10/29/2003 6:50:01 PM PST by Held_to_Ransom (Our forests are a disaster, especially where Uncle Sam cares for them.)
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To: BabaOreally
Only kills mice? I like it. Is it better than barbait? We need one that only kills spiders, snakes and coyotees.
40 posted on 10/29/2003 6:53:30 PM PST by NeonKnight
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