[DWPittelli]

Your math may be correct, but it is not relevant unless we assume that only a single one of the possible chains of 250 amino acids would work. Perhaps many would work. Perhaps all would work. And perhaps the simplest self-repicating structure had no DNA at all.

[AndrewC]

Your math may be correct, but it is not relevant unless we assume that only a single one of the possible chains of 250 amino acids would work.

They aren't amino acids, they are nucleic acids. They don't all self replicate. In fact, evidence is that none "self-replicate".