[Getready]

One reason why 3 or 4 meds given simultaneously work so well is because it is nearly impossible to get the 4 simultaneous mutations necessary which would allow a tumor to keep on growing in the face of treatment.

That’s why anti-HIV “cocktails”(no pun intended) use 3 or 4 different chemicals simultaneously which inhibit different HIV survival biochemical pathways.

[Myrddin]

My high school classmate with Stage 4 pancreatic cancer is expecting his daraxonrasib in hand shortly. His weight is down to 122 lbs. Hopefully he gets the full 13 months of extended life that seems to go with this medication. Too bad that the cancer is agile enough to work around it over time. The extra concurrent inhibitors might stretch that 13 months a bit longer.