Posted on 02/27/2026 10:20:03 AM PST by nickcarraway
Mo'Nique urged fans to think twice before jumping on the latest weight-loss trend.
In an emotional video shared online, the actress and comedian became visibly teary as she spoke directly to viewers about the growing popularity of GLP-1 medications.
Mo'Nique Questioned GLP-1's Long-Term Effects
Tap Here To Add Ok Magazine as A Trusted SourceAdd Ok Magazine as A Trusted Source on Google image of Mo'Nique shared an emotional message about the risks of GLP-1 weight-loss drugs. Source: mega Mo'Nique shared an emotional message about the risks of GLP-1 weight-loss drugs.
The drugs, which are commonly prescribed to help regulate blood sugar and support weight loss, have surged in demand, particularly as high-profile celebrities openly discuss their use.
But Mo'Nique made it clear she has serious concerns.
"What [are] the long-term effects? What will it do to your body? Your mind? What will it do to us five years from now, 10 years from now?" she asked, according to Essence, questioning whether people fully understand what they're putting into their systems.
“Love yourself enough not to be tricked.”
Mo'Nique warns people about the dangers of taking weight loss drugs and encourages people to research what they’re putting in their body.
She questioned what it will do to your mind and body.
While acknowledging that many users may be thrilled with their physical transformations, she cautioned that short-term results don't always guarantee long-term safety.
"You may get down to that size two or size four or that size eight or whatever that thing is. But I would ask you to research what you're putting in your body," she said.
The Oscar winner also suggested that social media and celebrity culture are influencing people to follow suit.
"They got us caught up in trends," Mo'Nique said, adding that ordinary individuals are being swayed by "big stars."
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I bet this cow was all for forcing people to take experimental covid drugs
Thass Doktoh Moe-Neek, ter yo!
She's giving good advice. GLP-1 drugs are a trend fueled by stories about stars losing weight on the "miracle drug" which probably aren't true or are only partially true. Most people are just going to go down a size or two (like she says) without thinking of side effects. I've watched Mo'Nique on a couple podcasts and she actually makes a lot of sense at times. She was one of the celebrities giving early warnings about P-Diddy. She was telling Shannon Sharpe that he was being stupid and reckless before his sex tapes were released. She can be off the wall too but she's worth listening to.
Any drug that is regulating your sugar levels and you are not already diabetic will likely mess you up in the long term. Nice way to lunch your pancreas.
How long do you have to take it?
For life!
What else do you lose?
Muscle!
As if being obese is healthy! LMAO.
Why would you assume that? She is very right to call for a cautious approach with these drugs. They do have long term effects besides weight loss (which is not always permanent). They are still a rather new drug but hey if they were developed with the help Gila Monster biology they have got to be 100 percent safe, right?
Junk food, soda, drugs and toxic exposure to black “beauty” products are far more of a threat to Mo’Nique’s fans than GLP-1.
Long-term use of GLP-1 receptor agonists (e.g., Ozempic, Wegovy) for weight loss commonly causes persistent gastrointestinal issues like nausea, vomiting, and constipation. Significant, lasting effects include muscle mass loss, gallbladder disease, potential pancreatitis, and rapid facial fat loss (”Ozempic face”).
GoodRx
GoodRx
+4
Key Long-Term Side Effects and Risks
Persistent Gastrointestinal Distress: While GI symptoms often subside, many users experience lasting nausea, diarrhea, or constipation.
Muscle Loss (Sarcopenia): Significant reduction in body weight often includes loss of lean muscle mass, which can affect metabolic health.
“Ozempic Face” & Skin Changes: Rapid weight loss causes sagging, wrinkles, or thinner-looking skin on the face.
Gallbladder Problems: Increased risk of gallstones and gallbladder inflammation.
Pancreatitis: Potential risk of pancreatic inflammation.
Nutrient Deficiencies: Drastically reduced appetite may lead to, or worsen, nutritional gaps.
Hair Loss: Some users experience alopecia (hair thinning).
Weight Regain: High likelihood of regaining weight once the medication is stopped.
Rare/Potential Risks: Emerging research is looking into potential links to thyroid cancers, vision-related complications (retinopathy), and psychiatric issues like depression or suicidal ideation in specific individuals.
Harvard Health
Harvard Health
+9
Mitigation Strategies
Resistance Exercise: Crucial to counteract muscle loss.
High Protein Intake: To help maintain lean muscle.
Hydration: Essential, particularly when suffering from gastrointestinal discomfort
Common complications of weight loss drugs, particularly GLP-1 receptor agonists (like Wegovy, Ozempic) and other agents, include significant gastrointestinal issues—nausea, vomiting, diarrhea, constipation, and stomach pain. Serious risks include pancreatitis, gallbladder disease, kidney problems, and potential muscle/bone loss. Rapid weight regain often occurs after stopping medication.
Gastrointestinal Issues: Severe nausea, vomiting, diarrhea, constipation, and stomach pain are the most reported side effects.
Gallbladder Issues: Increased risk of gallbladder disease.
Pancreatitis: A rare but serious risk involving inflammation of the pancreas.
Kidney Problems: Potential kidney issues or injury,
Severe, dehydration-inducing vomiting or diarrhea.
Muscle and Bone Loss: Losing muscle mass and bone density, which is of concern for older adults.
“Ozempic Face”: Sunken cheeks and sagging skin due to rapid, significant weight loss.
Thyroid Risks: Some medications (e.g., tirzepatide) carry warnings for potential thyroid C-cell tumors.
Heart Rate/Blood Pressure: Certain stimulants (e.g., phentermine) can cause increased heart rate and higher blood pressure.
Delayed Gastric Emptying: In rare cases, stomach paralysis (gastroparesis).
Weight Regain: Weight is frequently regained if the medication is stopped.
Lifestyle Impact: Reduced enjoyment of food, fatigue, and potential for malnutrition if food intake is too low.
Medication Dependence: These are often considered long-term, potentially lifelong, medications.
High Costs: Often expensive and not always covered by insurance.
Note: Always consult a healthcare provider for personalized medical advice regarding weight loss medications.
I’ve followed this subject quite a bit and unfortunately her emotional general information rant doesn’t add much to the discussion, except a certain degree of Common Sense.
Three potential risks have been identified. Thyroid cancer, a frozen stomach sort of syndrome, and a stroke like issue in the retina which can cause blindness.
Each of those risks requires further study and discussion. They are probably not major risks for the vast number of people out there. Also, consider that the medication can result in dramatic Improvement not just in weight but in related metabolic results.
When I see JB Pritzker and Tim Walz slimming down I wonder if they will be in the “small number” who are experiencing serious side effects. Or if they will show up later on.
I hear it can cause your stomach to stop working
Not disputing any of the risks you have listed, they are all real. When you investigate them, a lot appear to be the result of any rapid weight loss, not necessarily the mechanism for the weight loss.
But some are definitely drug-related.
What is the long term effect of heart disease?
The natural skinny are at advantage socially. Unattractive fatties becoming more attractive is a threat to their social status.
Is that a bad thing?
Take a look at Sharon Osbourne and her daughter Kelly. They look grotesque from Ozempic.
Exception not the rule.
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