I’m going to go against the grain here. First, there are a lot of mentally ill trangender people who have axes to grind and who are dangerous. IF they are walking around with guns, watch out. But it also is true that, in the past, gay people were attacked and beaten for being gay. There is a lot of unreported “black on gay” attacks in cities where the gay people are just walking down the street, minding their own business and they are attacked. Any vulnerable person - gay, female, transgender - who is at risk of being attacked has the right to defend themselves with a gun. Especially in the city.
I don't consider your comment to be "going against the grain", but I'd include "straight, male, etc." as being just as vulnerable, especially in the city. I lived in Philly in the 1970's when it was relatively safe to walk through most parts of the city, but not others, at least in daytime. These days I won't even drive through it.
All American citizens have 2nd Amendment rights, and we have to be very careful in deciding who's sane vs. who's insane enough to lose those rights for that reason. Red flag, slippery slope, all that stuff.
A person doesn't have to be gay, female, or transgender to be dangerously insane. And frankly, the majority of the many gay and female people I know are sane. I don't know that many transgender people, and they do seem to tend to the loopy a good bit more than average, but that might just be because they're all Democrats.